jats:pOrganic electrochemical transistors (OECTs) are a burgeoning biosensing transducer platform due to their intrinsic amplification, high transconductance, and biocompatibility. To be successful in real world biosensing applications, however, stable performance should be demonstrated to avoid false analyte readings that could lead to dangerous misdiagnosis. This work demonstrates the stability of carefully prepared OECTs using commercially available PEDOT:PSS as the channel layer. These devices exhibit more than 99% retention of the baseline current over 50 transfer curve cycles and, importantly, after several changes in electrolyte solution. Furthermore, impressive stability is demonstrated during continuous measurements of the drain current. These results show that PEDOT:PSS OECTs are ready for biosensing applications requiring accurate continuous monitoring.</jats:p>