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Integrating adipocyte insulin signaling and metabolism in the multi-omics era.

Accepted version
Peer-reviewed

Type

Article

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Authors

Calejman, C Martinez 
Doxsey, WG 
Fazakerley, DJ 
Guertin, DA 

Abstract

Insulin stimulates glucose uptake into adipocytes via mTORC2/AKT signaling and GLUT4 translocation and directs glucose carbons into glycolysis, glycerol for TAG synthesis, and de novo lipogenesis. Adipocyte insulin resistance is an early indicator of type 2 diabetes in obesity, a worldwide health crisis. Thus, understanding the interplay between insulin signaling and central carbon metabolism pathways that maintains adipocyte function, blood glucose levels, and metabolic homeostasis is critical. While classically viewed through the lens of individual enzyme-substrate interactions, advances in mass spectrometry are beginning to illuminate adipocyte signaling and metabolic networks on an unprecedented scale, yet this is just the tip of the iceberg. Here, we review how 'omics approaches help to elucidate adipocyte insulin action in cellular time and space.

Description

Keywords

glucose, insulin, metabolism, metabolomics, phosphoproteomics, white and brown adipose tissue, Adipocytes, Diabetes Mellitus, Type 2, Glucose, Humans, Insulin, Signal Transduction

Journal Title

Trends Biochem Sci

Conference Name

Journal ISSN

0968-0004
1362-4326

Volume Title

Publisher

Elsevier BV
Sponsorship
Medical Research Council (MR/S007091/1)
None from UK. NIH in USA and ANPCyT and Universidad de Buenos Aires in Argentina