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Genetically Predicted Neutrophil-to-Lymphocyte Ratio and Coronary Artery Disease: Evidence From Mendelian Randomization.

Published version
Peer-reviewed

Type

Article

Change log

Abstract

Inflammation contributes to atherosclerosis and coronary artery disease (CAD). In order to help identify therapeutic targets, it is important to ascertain whether biomarkers associated with CAD risk are causal. In a recent meta-analysis of clinical trials, neutrophil-to lymphocyte ratio (NLR) was associated with increased cardiovascular risk 1 . We investigate a potential causal nature of this relationship by performing Mendelian randomization (MR) analyses

Description

Keywords

cardiovascular diseases, causality, inflammation, linear models, neutrophils, Coronary Artery Disease, Genome-Wide Association Study, Humans, Lymphocytes, Mendelian Randomization Analysis, Neutrophils

Journal Title

Circ Genom Precis Med

Conference Name

Journal ISSN

2574-8300
2574-8300

Volume Title

15

Publisher

Ovid Technologies (Wolters Kluwer Health)
Sponsorship
Wellcome Trust (204623/Z/16/Z)
Medical Research Council (MC_UU_00002/7)
British Heart Foundation (None)
British Heart Foundation (CH/12/2/29428)
British Heart Foundation (RG/18/13/33946)