Stem cells "aclymatise" to regenerate the blood system.
Accepted version
Peer-reviewed
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Repository DOI
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Authors
Lisi-Vega, Livia E
Méndez-Ferrer, Simón
Abstract
How blood stem cells balance fate decisions between quiescence maintenance and differentiation during recovery from cancer treatment remains poorly understood. A recent study by Umemoto et al (2022) uncovers an unexpected linkage between metabolic and epigenetic regulation of haematopoiesis, suggesting new targets in haematopoietic regeneration, with possible implications in leukaemogenesis and therapy resistance.
Description
Keywords
Carcinogenesis, Epigenesis, Genetic, Hematopoiesis, Hematopoietic Stem Cells, Humans
Journal Title
EMBO J
Conference Name
Journal ISSN
0261-4189
1460-2075
1460-2075
Volume Title
Publisher
Springer Science and Business Media LLC
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Sponsorship
Medical Research Council (MC_PC_17230)
MRC (MR/V005421/1)
MRC (MR/V005421/1)