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Humoral immunity at the brain borders in homeostasis.

Accepted version
Peer-reviewed

Type

Article

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Authors

Posner, David A 
Lee, Colin Yc 
Portet, Anais 
Clatworthy, Menna R 

Abstract

The meninges encase the brain and spinal cord and house a variety of immune cells, including developing and mature B cells, and antibody-secreting plasma cells. In homeostasis, these cells localize around the dural venous sinuses, providing a defense 'zone' to protect the brain and spinal cord from blood-borne pathogens. Dural plasma cells predominantly secrete IgA antibodies, and some originate from the gastrointestinal tract, with the number and antibody isotype shaped by the gut microbiome. For developing B cells arriving from the adjacent bone marrow, the dura provides a site to tolerize against central nervous system antigens. In this review, we will discuss our current understanding of meningeal humoral immunity in homeostasis.

Description

Keywords

Brain, Dura Mater, Homeostasis, Humans, Immunity, Humoral, Meninges

Journal Title

Curr Opin Immunol

Conference Name

Journal ISSN

0952-7915
1879-0372

Volume Title

Publisher

Elsevier BV
Sponsorship
Wellcome Trust (220268/Z/20/Z)
Medical Research Council (MR/S035842/1)
DP is supported by a National Council of Science and Technology (CONACyT) of Mexico and Cambridge Trust PhD scholarship and CYCL by a Gates Scholarship. MRC was/is supported by a Wellcome Investigator Grant (220268/Z/20/Z), a Medical Research Council Research Project Grant (MR/S035842/1), a National Institute of Health Research (NIHR) Research Professorship RP-2017-08-ST2-002, and MRC and AP by the NIHR Cambridge Biomedical Research Centre. The views expressed are those of the author(s) and not necessarily those of the NHS, the NIHR or the Department of Health and Social Care.