Clinical utility of vinblastine therapeutic drug monitoring for the treatment of infantile myofibroma patients: A case series.
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Peer-reviewed
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Abstract
Infantile myofibroma is a rare, benign tumour of infancy typically managed surgically. In a minority of cases, more aggressive disease is seen and chemotherapy with vinblastine and methotrexate may be used, although evidence for this is limited. Chemotherapy dosing in infants is challenging, and vinblastine disposition in infants is unknown. We describe the use of vinblastine therapeutic drug monitoring in four cases of infantile myofibroma. Marked inter- and intrapatient variability was observed, highlighting the poorly understood pharmacokinetics of vinblastine in children, the challenges inherent in treating neonates, and the role of adaptive dosing in optimising drug exposure in challenging situations.
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Keywords
infantile myofibroma, neonate, pharmacokinetics, therapeutic drug monitoring, vinblastine, Child, Drug Monitoring, Humans, Infant, Infant, Newborn, Myofibroma, Myofibromatosis, Vinblastine
Journal Title
Pediatr Blood Cancer
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Journal ISSN
1545-5009
1545-5017
1545-5017
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Publisher
Wiley