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Hybrid fabrication of multimodal intracranial implants for electrophysiology and local drug delivery.

Accepted version
Peer-reviewed

Type

Article

Change log

Authors

Hilton, Sam 
Pezone, Roberto 
Curto, Vincenzo F 

Abstract

New fabrication approaches for mechanically flexible implants hold the key to advancing the applications of neuroengineering in fundamental neuroscience and clinic. By combining the high precision of thin film microfabrication with the versatility of additive manufacturing, we demonstrate a straight-forward approach for the prototyping of intracranial implants with electrode arrays and microfluidic channels. We show that the implant can modulate neuronal activity in the hippocampus through localized drug delivery, while simultaneously recording brain activity by its electrodes. Moreover, good implant stability and minimal tissue response are seen one-week post-implantation. Our work shows the potential of hybrid fabrication combining different manufacturing techniques in neurotechnology and paves the way for a new approach to the development of multimodal implants.

Description

Keywords

Cardiac Electrophysiology, Electrophysiological Phenomena, Microtechnology, Neurosciences, Prostheses and Implants

Journal Title

Mater Horiz

Conference Name

Journal ISSN

2051-6347
2051-6355

Volume Title

Publisher

Royal Society of Chemistry (RSC)
Sponsorship
Engineering and Physical Sciences Research Council (EP/S009000/1)
European Commission Horizon 2020 (H2020) Future and Emerging Technologies (FET) (732032)
Engineering and Physical Sciences Research Council (EP/L015978/1)