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Circulating MicroRNAs for Detection of Germ Cell Tumours: A Narrative Review.

Accepted version
Peer-reviewed

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Type

Article

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Authors

Fankhauser, Christian D 
Nuño, Michelle M 
Murray, Matthew J 
Frazier, Lindsay 
Bagrodia, Aditya 

Abstract

Testicular germ cell tumours (GCTs) are the most common malignancy among young men. Management of GCTs relies on the serum tumour markers α-fetoprotein, human chorionic gonadotropin, and lactate dehydrogenase, among other parameters. However, these tumour markers can only be detected at elevated levels in half of GCT patients. Circulating miR-371a-3p has emerged as a blood-based biomarker that can reliably detect macroscopic GCTs, aside from teratoma. Here we review the literature, describe the methodologies currently used to measure circulating miR-371a-3p, and discuss the following clinical scenarios in which miR-371a-3p may impact practice in the future: (1) men with an inconclusive small testicular mass; (2) response monitoring during chemotherapy; (3) postchemotherapy residual masses; and (4) follow-up after treatment with curative intent. PATIENT SUMMARY: We discuss the potential uses and promise, as well as current limitations, of a novel blood test that may improve care for men with testicular cancer.

Description

Keywords

Germ cell tumours, MicroRNA, Testis cancer, Tumour marker, Biomarkers, Tumor, Circulating MicroRNA, Humans, Male, MicroRNAs, Neoplasms, Germ Cell and Embryonal, Testicular Neoplasms

Journal Title

Eur Urol Focus

Conference Name

Journal ISSN

2405-4569
2405-4569

Volume Title

Publisher

Elsevier BV
Sponsorship
None