Repository logo
 

'Know thyself' - host factors influencing cancer response to immune checkpoint inhibitors.

Published version
Peer-reviewed

Change log

Authors

Manrique-Rincón, Andrea J  ORCID logo  https://orcid.org/0000-0002-8146-1495
Klein, Oliver 
Lawley, Trevor D 

Abstract

Immune checkpoint inhibitors (ICIs) have revolutionised oncology and are now standard-of-care for the treatment of a wide variety of solid neoplasms. However, tumour responses remain unpredictable, experienced by only a minority of ICI recipients across malignancy types. Therefore, there is an urgent need for better predictive biomarkers to identify a priori the patients most likely to benefit from these therapies. Despite considerable efforts, only three such biomarkers are FDA-approved for clinical use, and all rely on the availability of tumour tissue for immunohistochemical staining or genomic assays. There is emerging evidence that host factors - for example, genetic, metabolic, and immune factors, as well as the composition of one's gut microbiota - influence the response of a patient's cancer to ICIs. Tantalisingly, some of these factors are modifiable, paving the way for co-therapies that may enhance the therapeutic index of these treatments. Herein, we review key host factors that are of potential biomarker value for response to ICI therapy, with a particular focus on the proposed mechanisms for these influences. © 2022 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of The Pathological Society of Great Britain and Ireland.

Description

Funder: General Sir John Monash Foundation; Id: http://dx.doi.org/10.13039/501100017475


Funder: Victorian Cancer Agency; Id: http://dx.doi.org/10.13039/100008018

Keywords

biomarkers, germline, host, immune checkpoint inhibitors, immune system, immunotherapy, metabolome, microbiome, predictive, Humans, Immune Checkpoint Inhibitors, Immunologic Factors, Immunotherapy, Neoplasms, United Kingdom

Journal Title

J Pathol

Conference Name

Journal ISSN

0022-3417
1096-9896

Volume Title

Publisher

Wiley
Sponsorship
Cancer Research UK (A25117)