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Social and emotional characteristics of girls and young women with DDX3X-associated intellectual disability: a descriptive and comparative study.

Published version
Peer-reviewed

Type

Article

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Abstract

DDX3X variants are a common cause of intellectual disability (ID) in females, and have been associated with autism spectrum disorder and emotional-behavioural difficulties. In this study, we compared phenotypic data for 23 females with DDX3X variants, to 23 females with ID and other genetic diagnoses. We found a wide range of adaptive, social and emotional function within the DDX3X group. Autism characteristics did not differ between DDX3X and comparison groups, while levels of anxiety and self-injurious behaviour (SIB) were significantly higher in the DDX3X group. Within the DDX3X group, adaptive function, autism characteristics, anxiety and SIB scores were positively correlated, with evidence for group-specific associations with SIB. Future work is warranted to explore the multilevel mechanisms contributing to social and emotional development in individuals with DDX3X variants.

Description

Keywords

Anxiety, Autism, DDX3X, Intellectual disability, Self-injurious behaviour

Journal Title

J Autism Dev Disord

Conference Name

Journal ISSN

0162-3257
1573-3432

Volume Title

Publisher

Springer Science and Business Media LLC