1749-7922-3-22 1749-7922 Review <p>Emergency endovascular management of peripheral artery aneurysms and pseudoaneurysms – a review</p> Sadat Umar sadat.umar@gmail.com Kullar J Peter peter.kullar@addenbrookes.nhs.uk Noorani Ayesha ayesha.noorani@addenbrookes.nhs.uk Gillard H Jonathan jhg21@cam.ac.uk Cooper G David dg.coops@lineone.net Boyle R Jonathan jonathan.boyle@addenbrookes.nhs.uk

Cambridge Vascular Unit, Cambridge University Hospitals NHS Foundation Trust, UK

University Department of Radiology, Cambridge University Hospitals NHS Foundation Trust, UK

World Journal of Emergency Surgery 1749-7922 2008 3 1 22 http://www.wjes.org/content/3/1/22 18644114 10.1186/1749-7922-3-22
29 2 2008 21 7 2008 21 7 2008 2008 Sadat et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Endovascular stenting has been successfully employed in the management of aortic aneurysms; however, its use in managing peripheral arterial conditions remains questionable. We review the utility of endovascular technique in the management of peripheral arterial conditions like aneurysms, pseudoaneurysms and arterio-venous fistulas in the emergency setting. Though long term data about graft patency rates is not yet available, the endovascular approach appears to be a useful minimally invasive technique in situations where open repair is either difficult or not feasible.

Background

Popliteal aneurysms are the most common peripheral artery aneurysms, followed by femoral artery aneurysms. Patients with popliteal artery aneurysms have a 70% risk of concurrent abdominal aortic aneurysm (AAA). Similarly, patients with AAA have a 3.1% risk of popliteal aneurysm. Patients have bilateral popliteal artery aneurysms in 50–70% of cases 1. Patients with popliteal artery aneurysms usually present with critical limb ischemia, resulting from aneurysm thrombosis. Rupture of the popliteal aneurysms is uncommon.

Femoral aneurysms are asymptomatic in 30–40% of patients at the time of initial presentation. Approximately one third of patients presents with local symptoms such as groin pain or groin mass. Of patients presenting with femoral aneurysms 10–65% have complications at the time of initial presentation, including chronic thrombosis with claudication, acute thrombosis with limb ischaemia and rupture. Distal embolisation is less common. The majority of patients with femoral aneurysms have multiple aneurysms, with a 51–92% incidence of associated aorto-iliac aneurysmal disease 2. Peripheral arterial aneurysms have a male predominance. Common risk factors include smoking, hypertension and atherosclerosis.

Historically, aneurysms have been repaired by open technique, but over the last two decades endovascular stenting has been increasingly used for the management of aneurysmal and stenotic arterial conditions, particularly in the aorta. Different randomized controlled trials and comparative studies have shown early reduction in postoperative morbidity and mortality 3. But considerably longer follow up and re-intervention rates are some of the concerns related to the endovascular approach. Though this evidence stems from studies in the elective setting, no completed randomized controlled trials in emergency settings have been done to date. But, it would be unrealistic to assume that the limitations of endovascular stenting in the elective setting should limit its utility in the emergency setting. This is because this minimally invasive technique has significant benefits in the acute settings most importantly less surgical stress 3. This can be useful in patients who have significant co-morbidities and are otherwise not fit for open surgery 4. There is much less evidence about the usefulness of endovascular stenting in peripheral arteries.

Management

Peripheral aneurysmal disease

The first report of popliteal aneurysm stenting was by Marin et al when a Palmaz stent covered with polytetrafluoroethylene (PTFE) was used 5. Since then there have been reports of its use in treating popliteal aneurysms, with results equivalent to that of open technique. In a recent meta analysis, it was reported that endovascular technique offers similar medium term benefits as an open repair 6. There is only one randomised controlled trial that has reported comparable long-term results for endovascular repair compared with open repair 7. The position of the endograft behind the knee also makes the situation more complex. The flexion at the knee joint may possibly lead to kinking of the stent, predisposing to stent blockage/fracture 89. But careful endograft design and placement can help overcome this problem to an extent (Figure 1, 2). There are similar concerns about patients with femoral aneurysms who undergo endovascular stenting because of the movement at the hip joint. We have already reported the successful use of this technique in managing popliteal artery aneurysm in "hostile leg" 10. Further studies are warranted before it can be adopted as a treatment of first choice.

<p>Figure 1</p>

Popliteal artery aneurysm

Popliteal artery aneurysm.

<p>Figure 2</p>

Complete exclusion of popliteal aneurysm following endovascular stenting

Complete exclusion of popliteal aneurysm following endovascular stenting.

Arterio-venous fistulas and pseudoaneurysms

Endovascular stenting can also be used in treating arterio-venous fistulas/malformations and pseudoaneurysms in elective and emergency setting. This can be done by using covered stents or by coil embolization. There are many case reports in which it has been used to treat femoral 1112, popliteal 1314, tibial pseudoaneurysms 1516 and arterio-venous malformations 1718. In our experience this is a safe, minimally-invasive intervention which ensures an early return to work and a minimal hospital stay 19. The importance of endovascular stenting is quite significant in patients who develop pseudoaneurysms following orthopaedic procedures like total or partial knee replacement or during knee arthroplasty. These can present in both emergency and elective settings. Because of the hostile operative field, the endovascular approach offers a quick fix to the problem. Both covered stents and coils can be used depending upon the nature and extent of the arterial injury.

To avoid working in a difficult hostile operative field, this method is quite useful in managing patients with infectious arterio-venous fistulas/malformations. These are particularly common in intravenous drug abusers. We have already reported a case in which it was used to treat arterio-venous fistulas with a concurrent femoral pseudoaneurysm in an intra venous drug abuser, where open surgery was not possible due to the presence of a groin abscess (Figure 3, 4). Appropriate intravenous antibiotic cover is important in this scenario, to prevent graft infection 20.

<p>Figure 3</p>

Arterio-venous fistula of femoral artery

Arterio-venous fistula of femoral artery.

<p>Figure 4</p>

Complete exclusion of arterio-venous fistula following endovascular repair

Complete exclusion of arterio-venous fistula following endovascular repair.

Conclusion

The endovascular approach being minimally invasive, offers considerable benefits in the emergency setting, though long-term data about its efficacy is awaited.

Conflict of interests

The authors declare that they have no competing interests.

Acknowledgements

None, no funding.

<p>Popliteal artery disease: diagnosis and treatment</p> Radiographics 2004 24 2 467 79 10.1148/rg.242035117 15026594 <p>True and false aneurysms of the femoral artery</p> Semin Vasc Surg 2005 18 4 216 23 10.1053/j.semvascsurg.2005.09.008 16360579 <p>Endovascular vs open repair of acute abdominal aortic aneurysms – A systematic review and meta-analysis</p> Sadat U Boyle JR Walsh SR Tang T Varty K Hayes PD J Vasc Surg 2008 Jan 31 <p>Endovascular AAA repair attenuates the inflammatory and renal responses associated with conventional surgery</p> Boyle JR Goodall S Thompson JP Bell PR Thompson MM J Endovasc Ther 2000 7 5 359 71 10.1583/1545-1550(2000)007<0359:EARATI>2.0.CO;2 11032254 <p>Transfemoral endoluminal stented graft repair of a popliteal artery aneurysm</p> Marin ML Veith FJ Panetta TF Cynamon J Bakal CW Suggs WD Wengerter KR Baronè HD Schonholz C Parodi JC J Vasc Surg 1994 19 4 754 7 8164291 <p>Endovascular and Open Approaches to Non-thrombosed Popliteal Aneurysm Repair: A Meta-analysis</p> Lovegrove RE Javid M Magee TR Galland RB Eur J Vasc Endovasc Surg 2008 Apr 5 18396427 <p>Open repair versus endovascular treatment for asymptomatic popliteal artery aneurysm: results of a prospective randomized study</p> Antonello M Frigatti P Battocchio P J Vasc Surg 2005 42 2 185 93 10.1016/j.jvs.2005.04.049 16102611 <p>Biomechanical incompatibility of popliteal stent placement</p> Kroger K Santosa F Goyen M J Endovasc Ther 2004 11 6 686 94 10.1583/04-127.1 15615559 <p>Fracture of popliteal artery stents</p> Babalik E Gulbaran M Gurmen T Ozturk S Circ J 2003 67 643 645 10.1253/circj.67.643 12845192 <p>Endovascular Repair of a Popliteal Artery Aneurysm in a 'Hostile Leg</p> Sadat U Cousins C Boyle JR EJVES Extra 2007 14 48 50 10.1016/j.ejvsextra.2007.08.002 <p>Emergency stenting of a ruptured infected anastomotic femoral pseudoaneurysm</p> Klonaris C Katsargyris A Matthaiou A Giannopoulos A Tsigris C Papadopouli K Tsiodras S Bastounis E Cardiovasc Intervent Radiol 2007 30 6 1238 41 10.1007/s00270-007-9080-z 17516111 <p>Endovascular repair of a pseudo-aneurysm of the common femoral artery after revision total hip arthroplasty</p> D'Angelo F Piffaretti G Carrafiello G Tozzi M Caronno R Castelli P Zatti G Emerg Radiol 2007 14 4 233 6 10.1007/s10140-007-0605-1 17406911 <p>Treatment of a symptomatic popliteal pseudoaneurysm using a stent-graft and ultrasound-guided evacuation of the haematoma</p> Reijnen MM de Rhoter W Zeebregts CJ Emerg Radiol 2008 Jan 24 18214561 <p>Popliteal artery pseudoaneurysm after a revision of total knee arthroplasty: endovascular treatment with a stent graft</p> D'Angelo F Carrafiello GP Laganà D Reggiori A Giorgianni A Zatti G Fugazzola C Emerg Radiol 2007 13 6 323 7 10.1007/s10140-006-0553-1 17216179 <p>Endovascular treatment of anterior tibial artery pseudoaneurysm following locking compression plating of the tibia</p> van Hensbroek PB Ponsen KJ Reekers JA Goslings JC J Orthop Trauma 2007 21 4 279 82 10.1097/BOT.0b013e3180500371 17414557 <p>Peroneal artery pseudoaneurysm – a case report and literature review</p> Sadat U See T Cousins C Hayes P Gaunt M BMC Surg 7 4 2007 Mar 29 1851946 17394650 10.1186/1471-2482-7-4 <p>Endovascular treatment of a post-traumatic tibial pseudoaneurysm and arteriovenous fistula: case report and review of the literature</p> Spirito R Trabattoni P Pompilio G Zoli S Agrifoglio M Biglioli P J Vasc Surg 2007 45 5 1076 9 10.1016/j.jvs.2006.12.038 17466805 <p>Repair of a combined femoral pseudoaneurysm and arteriovenous fistula using a covered stent graft</p> Kendrick AS Sprouse LR 2nd Am Surg 2007 73 3 227 9 17375776 <p>Endovascular management of pseudoaneurysms following lower limb orthopedic surgery</p> Sadat U Naik J Verma P See TC Cousins C Chitnavis JP Varty K Gaunt M Am J Orthop 2008 18587511 <p>Endovascular management of an arteriovenous fistula and concomitant pseudoaneurysm in an intravenous drug abuser</p> Sadat U Noor N See T Hayes P Vasc Endovascular Surg 2008 Mar 3