CLUSTER: 2 SIZE 39 Members of cluster NM_002086, NM_006839, NM_003340, NM_006357, NM_013440, X62996, X62997, NM_014610, NM_021160, NM_003339, NM_016602, NM_002967, NM_001689, NM_006913, NM_000508, NM_002136, NM_032125, NM_032635, NM_006341, NM_007204, NM_001535, NM_007107, NM_022036, NM_006715, NM_003641, NM_080686, NM_013241, XM_046160, NM_005051, NM_022365, NM_006531, NM_001568, NM_005968, NM_004199, NM_013291, NM_004890, NM_003341, NM_014847, NM_002788 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:6508 proteolysis and peptidolysis 5/39 GO:30163 protein catabolism 5/39 GO:6464 protein modification 5/39 GO:6511 ubiquitin-dependent protein catabolism 5/39 GO:19941 modification-dependent protein catabolism 5/39 GO:6139 nucleobase, nucleoside, nucleotide and nucleic acid metabolism 4/39 GO:7166 cell surface receptor linked signal transduction 4/39 GO:6512 ubiquitin cycle 4/39 GO:42127 regulation of cell proliferation 2/39 GO:6350 transcription 1/39 GO:6351 transcription, DNA-dependent 1/39 cellular_component GO:16021 integral to membrane 9/39 GO:16020 membrane 9/39 GO:267 cell fraction 6/39 GO:5624 membrane fraction 4/39 GO:5783 endoplasmic reticulum 3/39 GO:5887 integral to plasma membrane 3/39 GO:5792 microsome 2/39 GO:42598 vesicular fraction 2/39 molecular_process GO:3674 molecular_function 31/39 GO:4871 signal transducer activity 6/39 GO:16874 ligase activity 5/39 GO:16879 ligase activity, forming carbon-nitrogen bonds 4/39 GO:16881 acid-D-amino acid ligase activity 4/39 GO:8639 small protein conjugating enzyme activity 4/39 GO:4842 ubiquitin-protein ligase activity 4/39 GO:4840 ubiquitin conjugating enzyme activity 4/39 GO:4888 transmembrane receptor activity 3/39 GO:4872 receptor activity 3/39 GO:4930 G-protein coupled receptor activity 2/39 GO:16798 hydrolase activity, acting on glycosyl bonds 2/39 GO:42277 peptide binding 2/39 GO:4553 hydrolase activity, hydrolyzing O-glycosyl compounds 2/39 CLUSTER: 15 SIZE 2 Members of cluster NM_000142, NM_022107 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:9653 morphogenesis 1/2 GO:7048 oncogenesis 1/2 GO:7166 cell surface receptor linked signal transduction 1/2 GO:7169 transmembrane receptor protein tyrosine kinase signaling pathway 1/2 GO:8543 FGF receptor signaling pathway 1/2 GO:7243 protein kinase cascade 1/2 GO:9887 organogenesis 1/2 GO:7167 enzyme linked receptor protein signaling pathway 1/2 GO:1501 skeletal development 1/2 GO:7259 JAK-STAT cascade 1/2 GO:165 MAPKKK cascade 1/2 cellular_component GO:5887 integral to plasma membrane 1/2 molecular_process GO:4714 transmembrane receptor protein tyrosine kinase activity 1/2 GO:4872 receptor activity 1/2 GO:4888 transmembrane receptor activity 1/2 GO:5007 fibroblast growth factor receptor activity 1/2 GO:4713 protein-tyrosine kinase activity 1/2 GO:19199 transmembrane receptor protein kinase activity 1/2 CLUSTER: 4 SIZE 15 Members of cluster BC036575, NM_012138, NM_033515, NM_016224, NM_003755, NM_003249, NM_005792, U81002, NM_014183, NM_003072, NG_001158, NM_004945, NM_000146, NM_002582, NM_001023 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:6996 organelle organization and biogenesis 2/15 GO:7010 cytoskeleton organization and biogenesis 2/15 GO:7017 microtubule-based process 2/15 GO:6875 metal ion homeostasis 1/15 GO:46916 transition metal ion homeostasis 1/15 GO:8104 protein localization 1/15 GO:9451 RNA modification 1/15 GO:30005 di-, tri-valent inorganic cation homeostasis 1/15 GO:6916 anti-apoptosis 1/15 GO:30705 cytoskeleton-dependent intracellular transport 1/15 GO:7292 female gamete generation 1/15 GO:7632 visual behavior 1/15 GO:42592 homeostasis 1/15 GO:30003 cation homeostasis 1/15 GO:19725 cell homeostasis 1/15 GO:7018 microtubule-based movement 1/15 GO:6873 cell ion homeostasis 1/15 GO:6879 iron ion homeostasis 1/15 cellular_component GO:5868 cytoplasmic dynein complex 1/15 GO:8043 ferritin complex 1/15 GO:30286 dynein complex 1/15 molecular_process GO:46914 transition metal ion binding 2/15 GO:3774 motor activity 2/15 GO:8237 metallopeptidase activity 1/15 GO:8549 dynamine GTPase activity 1/15 GO:5506 iron ion binding 1/15 GO:8189 apoptosis inhibitor activity 1/15 GO:3777 microtubule motor activity 1/15 GO:4222 metalloendopeptidase activity 1/15 CLUSTER: 13 SIZE 2 Members of cluster NM_130463, NM_001696 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:9206 purine ribonucleoside triphosphate biosynthesis 2/2 GO:9150 purine ribonucleotide metabolism 2/2 GO:6810 transport 2/2 GO:9144 purine nucleoside triphosphate metabolism 2/2 GO:6163 purine nucleotide metabolism 2/2 GO:9201 ribonucleoside triphosphate biosynthesis 2/2 GO:9142 nucleoside triphosphate biosynthesis 2/2 GO:6812 cation transport 2/2 GO:8151 cell growth and/or maintenance 2/2 GO:6731 coenzymes and prosthetic group metabolism 2/2 GO:6811 ion transport 2/2 GO:6753 nucleoside phosphate metabolism 2/2 GO:6732 coenzyme metabolism 2/2 GO:9117 nucleotide metabolism 2/2 GO:9058 biosynthesis 2/2 GO:15992 proton transport 2/2 GO:6754 ATP biosynthesis 2/2 GO:9205 purine ribonucleoside triphosphate metabolism 2/2 GO:9199 ribonucleoside triphosphate metabolism 2/2 GO:9165 nucleotide biosynthesis 2/2 GO:9259 ribonucleotide metabolism 2/2 GO:6818 hydrogen transport 2/2 GO:6752 group transfer coenzyme metabolism 2/2 GO:9108 coenzyme biosynthesis 2/2 GO:9145 purine nucleoside triphosphate biosynthesis 2/2 GO:46034 ATP metabolism 2/2 GO:15672 monovalent inorganic cation transport 2/2 GO:9152 purine ribonucleotide biosynthesis 2/2 GO:9141 nucleoside triphosphate metabolism 2/2 GO:6164 purine nucleotide biosynthesis 2/2 GO:9260 ribonucleotide biosynthesis 2/2 GO:46138 coenzymes and prosthetic group biosynthesis 2/2 GO:15985 energy coupled proton transport, down the electrochemical gradient 1/2 GO:6119 oxidative phosphorylation 1/2 GO:15986 ATP synthesis coupled proton transport 1/2 cellular_component GO:45259 proton-transporting ATP synthase complex 1/2 GO:16469 proton-transporting two-sector ATPase complex 1/2 GO:5753 proton-transporting ATP synthase complex (sensu Eukarya) 1/2 GO:45255 hydrogen-translocating F-type ATPase complex 1/2 GO:19866 inner membrane 1/2 GO:5740 mitochondrial membrane 1/2 GO:5743 mitochondrial inner membrane 1/2 GO:219 vacuolar hydrogen-transporting ATPase 1/2 GO:5739 mitochondrion 1/2 molecular_process GO:15077 monovalent inorganic cation transporter activity 2/2 GO:16787 hydrolase activity 2/2 GO:8324 cation transporter activity 2/2 GO:15078 hydrogen ion transporter activity 2/2 GO:8369 obsolete molecular function 2/2 GO:15075 ion transporter activity 2/2 GO:5215 transporter activity 2/2 GO:3936 hydrogen-transporting two-sector ATPase activity 2/2 GO:42625 ATPase activity, coupled to transmembrane movement of ions 1/2 GO:8553 hydrogen-exporting ATPase activity, phosphorylative mechanism 1/2 GO:15399 primary active transporter activity 1/2 GO:15662 ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism 1/2 GO:16820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances 1/2 GO:15405 P-P-bond-hydrolysis-driven transporter activity 1/2 GO:42626 ATPase activity, coupled to transmembrane movement of substances 1/2 GO:5386 carrier activity 1/2 GO:260 hydrogen-translocating V-type ATPase activity 1/2 CLUSTER: 9 SIZE 22 Members of cluster BC001200, NM_003077, NM_015045, NM_031157, NM_017876, NM_032690, NM_012073, NM_003819, NM_022827, NM_003021, NM_032907, NM_004639, NM_080545, NM_005843, NM_018072, NM_001273, NM_005566, NM_019001, NM_000034, NM_013379, NM_015965, AI821928 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:8151 cell growth and/or maintenance 8/22 GO:6810 transport 6/22 GO:46907 intracellular transport 5/22 GO:9056 catabolism 5/22 GO:6886 intracellular protein transport 4/22 GO:15031 protein transport 4/22 GO:6997 nuclear organization and biogenesis 2/22 GO:6357 regulation of transcription from Pol II promoter 2/22 GO:6096 glycolysis 2/22 GO:16568 chromatin modification 2/22 GO:46365 monosaccharide catabolism 2/22 GO:6006 glucose metabolism 2/22 GO:6092 main pathways of carbohydrate metabolism 2/22 GO:5996 monosaccharide metabolism 2/22 GO:6605 protein targeting 2/22 GO:16052 carbohydrate catabolism 2/22 GO:19318 hexose metabolism 2/22 GO:6007 glucose catabolism 2/22 GO:6913 nucleocytoplasmic transport 2/22 GO:15980 energy derivation by oxidation of organic compounds 2/22 GO:6325 establishment and/or maintenance of chromatin architecture 2/22 GO:46164 alcohol catabolism 2/22 GO:6323 DNA packaging 2/22 GO:19320 hexose catabolism 2/22 GO:7001 chromosome organization and biogenesis (sensu Eukarya) 2/22 cellular_component GO:5654 nucleoplasm 3/22 molecular_process CLUSTER: 6 SIZE 4 Members of cluster NM_015456, NM_002904, XM_114002, NM_006311 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process cellular_component molecular_process GO:3714 transcription co-repressor activity 1/4 CLUSTER: 11 SIZE 7 Members of cluster NM_032454, NM_006231, NM_005850, NM_006115, NM_002696, NM_004955, M97191 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:6974 response to DNA damage stimulus 2/7 GO:6950 response to stress 2/7 GO:6259 DNA metabolism 2/7 GO:6281 DNA repair 2/7 GO:9719 response to endogenous stimulus 2/7 GO:15858 nucleoside transport 1/7 GO:6289 nucleotide-excision repair 1/7 GO:6283 transcription-coupled nucleotide-excision repair 1/7 cellular_component GO:30880 RNA polymerase complex 1/7 GO:5665 DNA-directed RNA polymerase II, core complex 1/7 GO:16591 DNA-directed RNA polymerase II, holoenzyme 1/7 molecular_process GO:16740 transferase activity 3/7 GO:16772 transferase activity, transferring phosphorus-containing groups 3/7 GO:16779 nucleotidyltransferase activity 2/7 GO:3887 DNA-directed DNA polymerase activity 1/7 GO:3890 beta DNA polymerase activity 1/7 GO:17125 deoxycytidyl transferase activity 1/7 GO:5337 nucleoside transporter activity 1/7 GO:16000 iota DNA polymerase activity 1/7 GO:16449 lambda DNA polymerase activity 1/7 GO:19984 sigma DNA polymerase activity 1/7 GO:16451 nu DNA polymerase activity 1/7 GO:3893 epsilon DNA polymerase activity 1/7 GO:3891 delta DNA polymerase activity 1/7 GO:3900 DNA-directed RNA polymerase I activity 1/7 GO:3894 zeta DNA polymerase activity 1/7 GO:16450 kappa DNA polymerase activity 1/7 GO:19986 deoxycytidyl transferase activity, template dependent 1/7 GO:3889 alpha DNA polymerase activity 1/7 GO:3899 DNA-directed RNA polymerase activity 1/7 GO:15999 eta DNA polymerase activity 1/7 GO:3895 gamma DNA-directed DNA polymerase activity 1/7 GO:16452 theta DNA polymerase activity 1/7 GO:8222 tumor antigen 1/7 GO:3901 DNA-directed RNA polymerase II activity 1/7 GO:16448 mu DNA polymerase activity 1/7 GO:3902 DNA-directed RNA polymerase III activity 1/7 GO:15932 nucleobase, nucleoside, nucleotide and nucleic acid transporter activity 1/7 GO:30145 manganese ion binding 1/7 CLUSTER: 1 SIZE 18 Members of cluster NM_002586, NM_017740, NM_017775, NM_012424, AL579387, NM_022743, NM_017451, NM_006833, BC009263, NM_023010, XM_042108, NM_000968, NM_003640, NM_007234, NM_006337, NM_032251, NM_001487, NM_016553 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process cellular_component GO:15630 microtubule cytoskeleton 3/18 GO:5856 cytoskeleton 3/18 GO:5871 kinesin complex 2/18 molecular_process CLUSTER: 3 SIZE 190 Members of cluster NM_024710, NM_052850, NM_007080, NM_005066, NM_014329, NM_138363, NM_025072, NM_003095, NM_018403, NM_003325, NM_020158, NM_003443, NM_015453, NM_006360, NM_006277, NM_016082, NM_003757, NM_004539, NM_002415, NM_005957, NM_080632, NM_016042, NM_014287, U80752, BC040175, NM_012475, NM_003407, AW275464, NM_005348, NM_006384, Q9UM59, NM_014953, NM_003146, NM_004475, NM_014462, AV753896, NM_014463, NM_003958, NM_022742, NM_006716, NM_014285, XM_072118, NM_000986, NM_017491, AK090737, NM_000754, NM_004159, NM_007006, NM_003929, NM_017727, NM_002688, NM_002180, NM_016046, NM_006916, NM_005716, NM_019037, NM_012322, NM_032520, NM_006033, BC045623, NM_152624, NM_031471, AI685517, NM_002797, NM_006666, NM_014484, NM_001028, NM_153477, NM_002685, AK021996, NM_019082, NM_021177, NM_031208, NM_004628, NM_001212, NM_016199, NM_170715, NM_001539, NM_012321, AW975586, NM_005197, NM_017567, NM_014828, NM_014062, NM_004451, AB037811, XM_371417, NM_152640, NM_017547, NM_007375, NM_004688, NM_144693, NM_003687, NM_017958, XM_113678, NM_016200, NM_000909, AB046824, FLJ40491, NM_005510, NM_004175, NM_014487, BF210065, NM_018103, NM_014615, NM_016121, BQ668976, NM_006938, AL137461, NM_032498, NM_001970, NM_080599, NM_004597, AK074364, NM_015356, NM_012255, XM_302813, NM_024536, NM_032999, NM_020679, NM_032317, NM_003094, XM_054951, NM_003017, AK027187, NM_018677, BF686613, XM_085017, NM_003935, NM_006929, BM451300, AK096810, NM_002654, NM_032558, NM_032822, AW974116, NM_015508, NM_015360, BG403593, NM_002212, NM_016404, NM_001288, NM_005483, NM_052965, NM_002911, NM_003091, AI620703, NM_022818, NM_001402, NM_019009, NM_032881, AK074101, NM_016328, BQ277691, NM_002793, NM_033536, NM_024569, PDCD2, NM_015681, NM_014664, NM_002631, NM_006755, NM_012203, NM_016091, NM_001018, NM_006066, NM_024741, AK091455, NM_021729, NM_018161, BQ069192, AB037839, AJ420488, NM_006230, NM_058219, AI580336, NM_013446, NM_014064, BU663601, NM_003802, NM_002689, BC045575, NM_170743, NM_015004, NM_031370, NM_007273, NM_012414, AB067488, XM_033181, BC008502 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:16070 RNA metabolism 32/190 GO:6396 RNA processing 31/190 GO:8371 obsolete biological process 26/190 GO:19538 protein metabolism 23/190 GO:6397 mRNA processing 20/190 GO:6371 mRNA splicing 18/190 GO:8380 RNA splicing 17/190 GO:375 RNA splicing, via transesterification reactions 17/190 GO:377 RNA splicing, via transesterification reactions with bulged adenosine as nucleophile 17/190 GO:398 nuclear mRNA splicing, via spliceosome 17/190 GO:42254 ribosome biogenesis and assembly 9/190 GO:7046 ribosome biogenesis 9/190 GO:6364 rRNA processing 9/190 GO:6360 transcription from Pol I promoter 9/190 GO:6810 transport 6/190 GO:46907 intracellular transport 3/190 GO:6464 protein modification 3/190 GO:16310 phosphorylation 1/190 GO:6796 phosphate metabolism 1/190 GO:6793 phosphorus metabolism 1/190 GO:6468 protein amino acid phosphorylation 1/190 cellular_component GO:5730 nucleolus 19/190 GO:5732 small nucleolar ribonucleoprotein complex 14/190 GO:30532 small nuclear ribonucleoprotein complex 7/190 GO:16020 membrane 6/190 GO:5886 plasma membrane 3/190 GO:16021 integral to membrane 3/190 GO:5654 nucleoplasm 1/190 GO:5887 integral to plasma membrane 1/190 molecular_process GO:3824 catalytic activity 41/190 GO:8248 pre-mRNA splicing factor activity 15/190 GO:3734 small nuclear ribonucleoprotein 8/190 GO:16740 transferase activity 7/190 GO:16301 kinase activity 4/190 GO:16772 transferase activity, transferring phosphorus-containing groups 3/190 GO:4674 protein serine/threonine kinase activity 2/190 GO:4672 protein kinase activity 2/190 GO:16773 phosphotransferase activity, alcohol group as acceptor 2/190 GO:46914 transition metal ion binding 1/190 CLUSTER: 14 SIZE 4 Members of cluster BM310104, NM_023011, NM_002093, NM_006435 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:6402 mRNA catabolism 1/4 GO:6073 glucan metabolism 1/4 GO:5976 polysaccharide metabolism 1/4 GO:184 mRNA catabolism, nonsense-mediated 1/4 GO:6112 energy reserve metabolism 1/4 GO:5977 glycogen metabolism 1/4 cellular_component molecular_process GO:4690 cyclic-nucleotide dependent protein kinase activity 1/4 GO:4691 Camp-dependent protein kinase activity 1/4 GO:5478 intracellular transporter activity 1/4 GO:5487 nucleocytoplasmic transporter activity 1/4 GO:4696 glycogen synthase kinase 3 activity 1/4 CLUSTER: 7 SIZE 8 Members of cluster NM_001320, NM_001895, NM_002350, NM_006349, XM_012804, NM_000969, NM_003925, NM_001896 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:19538 protein metabolism 4/8 GO:7154 cell communication 4/8 GO:7165 signal transduction 4/8 GO:6793 phosphorus metabolism 3/8 GO:16310 phosphorylation 3/8 GO:6468 protein amino acid phosphorylation 3/8 GO:6464 protein modification 3/8 GO:6796 phosphate metabolism 3/8 GO:7286 spermatid development 1/8 GO:30154 cell differentiation 1/8 GO:7283 spermatogenesis 1/8 GO:48232 male gamete generation 1/8 GO:6284 base-excision repair 1/8 cellular_component GO:5941 unlocalized 1/8 GO:5956 protein kinase CK2 complex 1/8 molecular_process GO:3824 catalytic activity 6/8 GO:16773 phosphotransferase activity, alcohol group as acceptor 5/8 GO:4672 protein kinase activity 5/8 GO:16740 transferase activity 5/8 GO:16301 kinase activity 5/8 GO:16772 transferase activity, transferring phosphorus-containing groups 5/8 GO:4674 protein serine/threonine kinase activity 4/8 GO:4682 protein kinase CK2 activity 3/8 GO:17076 purine nucleotide binding 3/8 GO:4680 casein kinase activity 3/8 GO:5524 ATP binding 3/8 GO:166 nucleotide binding 3/8 GO:30554 adenyl nucleotide binding 3/8 GO:4690 cyclic-nucleotide dependent protein kinase activity 2/8 GO:30234 enzyme regulator activity 2/8 GO:4691 cAMP-dependent protein kinase activity 2/8 GO:19207 kinase regulator activity 2/8 GO:19887 protein kinase regulator activity 2/8 GO:4693 cyclin-dependent protein kinase activity 1/8 GO:4519 endonuclease activity 1/8 GO:4520 endodeoxyribonuclease activity 1/8 GO:3696 satellite DNA binding 1/8 GO:4536 deoxyribonuclease activity 1/8 GO:8605 protein kinase CK2, intrinsic regulator activity 1/8 GO:16538 cyclin-dependent protein kinase, intrinsic regulator activity 1/8 GO:19843 rRNA binding 1/8 GO:8097 5S rRNA binding 1/8 GO:4716 receptor signaling protein tyrosine kinase activity 1/8 CLUSTER: 5 SIZE 12 Members of cluster NM_007222, NM_138394, NM_004671, NM_001019, NM_032364, NM_022740, NM_005033, NM_004640, NM_005782, NM_003211, XM_040002, NM_005804 Significant GO terms for this cluster (cluster proteins with this annotation/cluster size) biological_process GO:6406 mRNA-nucleus export 1/12 cellular_component GO:5622 intracellular 9/12 GO:5623 cell 9/12 GO:5634 nucleus 8/12 molecular_process GO:3676 nucleic acid binding 7/12 GO:3677 DNA binding 4/12 GO:30528 transcription regulator activity 3/12 GO:700 mismatch base pair DNA N-glycosylase activity 1/12 GO:8263 pyrimidine-specific mismatch base pair DNA N-glycosylase activity 1/12 GO:16799 hydrolase activity, hydrolyzing N-glycosyl compounds 1/12 GO:19104 DNA N-glycosylase activity 1/12