BMRI BioMed Research International 2314-6141 2314-6133 Hindawi Publishing Corporation 821310 10.1155/2013/821310 821310 Review Article Tumor Necrosis Factor Receptor 2: Its Contribution to Acute Cellular Rejection and Clear Cell Renal Carcinoma Wang Jun jw389@medschl.cam.ac.uk 1 Al-Lamki Rafia S. rsma2@hermes.cam.ac.uk 2 Maeda Shin 1 Department of Nephrology First Hospital of China Medical University Shenyang China cmu.edu.tw 2 Department of Medicine Cambridge University NHS Trust Hospitals Addenbrooke’s Hospital P.O. Box 157, Level 5, Hill’s Road Cambridge CB2 0QQ UK cam.ac.uk 2013 17112013 2013 25 08 2013 15 10 2013 17 10 2013 2013 Copyright © 2013 Jun Wang and Rafia S. Al-Lamki. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Tumor necrosis factor receptor 2 (TNFR2) is a type I transmembrane glycoprotein and one of the two receptors that orchestrate the complex biological functions of tumor necrosis factor (TNF, also designed TNF-α). Accumulating experimental evidence suggests that TNFR2 plays an important role in renal disorders associated with acute cellular rejection and clear cell renal carcinoma but its exact role in these settings is still not completely understood. This papers reviews the factors that may mediate TNFR2 induction in acute cellular rejection and clear cell renal carcinoma and its contribution to these conditions and discusses its therapeutic implications. A greater understanding of the function of TNFR2 may lead to the development of new anti-TNF drugs.

http://dx.doi.org/10.13039/501100001809 National Natural Science Foundation of China 30971120