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Mary F. Feitosa, Aldi T. Kraja, Daniel I. Chasman, Yun J. Sung, Thomas W. Winkler, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini, Ching-Yu Cheng, Xueling Sim, Dina Vojinovic, Jonathan Marten, Solomon K. Musani, Changwei Li, Amy R. Bentley, Michael R. Brown, Karen Schwander, Melissa A. Richard, Raymond Noordam, Hugues Aschard, Traci M. Bartz, Lawrence F. Bielak, Rajkumar Dorajoo, Virginia Fisher, Fernando P. Hartwig, Andrea R. V. R. Horimoto, Kurt K. Lohman, Alisa K. Manning, Tuomo Rankinen, Albert V. Smith, Salman M. Tajuddin, Mary K. Wojczynski, Maris Alver, Mathilde Boissel, Qiuyin Cai, Archie Campbell, Jin Fang Chai, Xu Chen, Jasmin Divers, Chuan Gao, Anuj Goel, Yanick Hagemeijer, Sarah E. Harris, Meian He, Fang-Chi Hsu, Anne U. Jackson, Mika Kähönen, Anuradhani Kasturiratne, Pirjo Komulainen, Brigitte Kühnel, Federica Laguzzi, Jian'an Luan, Nana Matoba, Ilja M. Nolte, Sandosh Padmanabhan, Muhammad Riaz, Rico Rueedi, Antonietta Robino, M. Abdullah Said, Robert A. Scott, Tamar Sofer, Alena Stančáková, Fumihiko Takeuchi, Bamidele O. Tayo, Peter J. van der Most, Tibor V. Varga, Veronique Vitart, Yajuan Wang, Erin B. Ware, Helen R. Warren, Stefan Weiss, Wanqing Wen, Lisa R. Yanek, Weihua Zhang, Jing Hua Zhao, Saima Afaq, Najaf Amin, Marzyeh Amini, Dan E. Arking, Tin Aung, Eric Boerwinkle, Ingrid Borecki, Ulrich Broeckel, Morris Brown, Marco Brumat, Gregory L. Burke, Mickaël Canouil, Aravinda Chakravarti, Sabanayagam Charumathi, Yii-Der Ida Chen, John M. Connell, Adolfo Correa, Lisa de las Fuentes, Renée de Mutsert, H. Janaka de Silva, Xuan Deng, Jingzhong Ding, Qing Duan, Charles B. Eaton, Georg Ehret, Ruben N. Eppinga, Evangelos Evangelou, Jessica D. Faul, Stephan B. Felix, Nita G. Forouhi, Terrence Forrester, Oscar H. Franco, Yechiel Friedlander, Ilaria Gandin, He Gao, Mohsen Ghanbari, Bruna Gigante, C. Charles Gu, Dongfeng Gu, Saskia P. Hagenaars, Göran Hallmans, Tamara B. Harris, Jiang He, Sami Heikkinen, Chew-Kiat Heng, Makoto Hirata, Barbara V. Howard, M. Arfan Ikram, InterAct Consortium, Ulrich John, Tomohiro Katsuya, Chiea Chuen Khor, Tuomas O. Kilpeläinen, Woon-Puay Koh, José E. Krieger, Stephen B. Kritchevsky, Michiaki Kubo, Johanna Kuusisto, Timo A. Lakka, Carl D. Langefeld, Claudia Langenberg, Lenore J. Launer, Benjamin Lehne, Cora E. Lewis, Yize Li, Shiow Lin, Jianjun Liu, Jingmin Liu, Marie Loh, Tin Louie, Reedik Mägi, Colin A. McKenzie, Thomas Meitinger, Andres Metspalu, Yuri Milaneschi, Lili Milani, Karen L. Mohlke, Yukihide Momozawa, Mike A. Nalls, Christopher P. Nelson, Nona Sotoodehnia, Jill M. Norris, Jeff R. O'Connell, Nicholette D. Palmer, Thomas Perls, Nancy L. Pedersen, Annette Peters, Patricia A. Peyser, Neil Poulter, Leslie J. Raffel, Olli T. Raitakari, Kathryn Roll, Lynda M. Rose, Frits R. Rosendaal, Jerome I. Rotter, Carsten O. Schmidt, Pamela J. Schreiner, Nicole Schupf, William R. Scott, Peter S. Sever, Yuan Shi, Stephen Sidney, Mario Sims, Colleen M. Sitlani, Jennifer A. Smith, Harold Snieder, John M. Starr, Konstantin Strauch, Heather M. Stringham, Nicholas Y. Q. Tan, Hua Tang, Kent D. Taylor, Yik Ying Teo, Yih Chung Tham, Stephen T. Turner, André G. Uitterlinden, Peter Vollenweider, Melanie Waldenberger, Lihua Wang, Ya Xing Wang, Wen Bin Wei, Christine Williams, Jie Yao, Caizheng Yu, Jian-Min Yuan, Wei Zhao, Alan B. Zonderman, Diane M. Becker, Michael Boehnke, Donald W. Bowden, John C. Chambers, Ian J. Deary, Tõnu Esko, Martin Farrall, Paul W. Franks, Barry I. Freedman, Philippe Froguel, Paolo Gasparini, Christian Gieger, Jost Bruno Jonas, Yoichiro Kamatani, Norihiro Kato, Jaspal S. Kooner, Zoltán Kutalik, Markku Laakso, Cathy C. Laurie, Karin Leander, Terho Lehtimäki, Lifelines Cohort Study, Patrik K. E. Magnusson, Albertine J. Oldehinkel, Brenda W. J. H. Penninx, Ozren Polasek, David J. Porteous, Rainer Rauramaa, Nilesh J. Samani, James Scott, Xiao-Ou Shu, Pim van der Harst, Lynne E. Wagenknecht, Nicholas J. Wareham, Hugh Watkins, David R. Weir, Ananda R. Wickremasinghe, Tangchun Wu, Wei Zheng, Claude Bouchard, Kaare Christensen, Michele K. Evans, Vilmundur Gudnason, Bernardo L. Horta, Sharon L. R. Kardia, Yongmei Liu, Alexandre C. Pereira, Bruce M. Psaty, Paul M. Ridker, Rob M. van Dam, W. James Gauderman, Xiaofeng Zhu, Dennis O. Mook-Kanamori, Myriam Fornage, Charles N. Rotimi, L. Adrienne Cupples, Tanika N. Kelly, Ervin R. Fox, Caroline Hayward, Cornelia M. van Duijn, E Shyong Tai, Tien Yin Wong, Charles Kooperberg, Walter Palmas, Kenneth Rice, Alanna C. Morrison, Paul Elliott, Mark J. Caulfield, Patricia B. Munroe, Dabeeru C. Rao, Michael A. Province, Daniel Levy
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
www.plosone.org
www.plosone.org
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6.7498 0 0 5.9992 320.5984 624.0755 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(39)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 328.0251 620.0503 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
0.4976 0 Td
(Pim)Tj
2.0346 0 Td
(van)Tj
1.9276 0 Td
(der)Tj
1.7575 0 Td
(Harst)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 406.6015 624.0755 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(45,181)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 426.9543 620.0503 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
0.4976 0 Td
(Lynne)Tj
3.1433 0 Td
(E.)Tj
1.1591 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 528.1511 624.0755 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(84)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 535.5212 620.0503 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
-37.2787 -1.222 Td
(Nicholas)Tj
4.3465 0 Td
(J.)Tj
1.0456 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 288.6236 613.0771 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(57)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 295.9937 609.0519 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
0.4976 0 Td
(Hugh)Tj
2.759 0 Td
(Watkins)Tj
ET
Q
q
1 j
1 J
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6.7498 0 0 5.9992 359.5464 613.0771 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(43,44)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 376.1574 609.0519 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
0.4976 0 Td
(David)Tj
2.9165 0 Td
(R.)Tj
1.2095 0 Td
(Weir)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 437.1023 613.0771 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
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(72)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 444.4724 609.0519 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
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(,)Tj
0.4976 0 Td
(Ananda)Tj
3.8551 0 Td
(R.)Tj
1.2095 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 565.3417 613.0771 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(52)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 572.7685 609.0519 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
-41.4173 -1.222 Td
(Tangchun)Tj
4.9701 0 Td
(Wu)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 258.6897 602.0787 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(48)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 266.1165 598.0535 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
0.4976 0 Td
(Wei)Tj
1.9842 0 Td
(Zheng)Tj
ET
Q
q
1 j
1 J
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6.7498 0 0 5.9992 315.3259 602.0787 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
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(39)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 322.696 598.0535 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
0.4976 0 Td
(Claude)Tj
3.5275 0 Td
(Bouchard)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 400.5354 602.0787 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
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(33)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 407.9055 598.0535 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
0.4976 0 Td
(Kaare)Tj
2.9543 0 Td
(Christensen)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 490.4503 602.0787 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(182)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 501.5622 598.0535 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
0.4913 0 Td
(Michele)Tj
-33.9968 -1.222 Td
(K.)Tj
1.2095 0 Td
(Evans)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 237.0897 591.0803 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(36)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 244.5165 587.0551 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
0.4913 0 Td
(Vilmundur)Tj
5.1338 0 Td
(Gudnason)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 339.4204 591.0803 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
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(34,35)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 356.0881 587.0551 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
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(,)Tj
0.4976 0 Td
(Bernardo)Tj
4.6173 0 Td
(L.)Tj
1.1024 0 Td
(Horta)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 435.2881 591.0803 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(27)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 442.6582 587.0551 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
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(,)Tj
0.4976 0 Td
(Sharon)Tj
3.6409 0 Td
(L.)Tj
1.1024 0 Td
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1.2094 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 528.3779 591.0803 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(24)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 535.8047 587.0551 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
0 0 Td
(,)Tj
-37.3102 -1.222 Td
(Yongmei)Tj
4.4158 0 Td
(Liu)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 253.1905 580.0818 cm
BT
/F2 1 Tf
1 TL
-0.0059 Tc
0 0 Td
(183)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 264.3023 576.0566 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
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(,)Tj
0.4913 0 Td
(Alexandre)Tj
5.0016 0 Td
(C.)Tj
1.2094 0 Td
(Pereira)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 354.6708 580.0818 cm
BT
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1 TL
-0.0059 Tc
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(29)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 362.0976 576.0566 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
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(,)Tj
0.4976 0 Td
(Bruce)Tj
3.0173 0 Td
(M.)Tj
1.3228 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 429.3354 580.0818 cm
BT
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1 TL
-0.0059 Tc
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(184,185)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 453.3732 576.0566 cm
BT
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1 TL
-0.0044 Tc
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(,)Tj
0.4913 0 Td
(Paul)Tj
2.3181 0 Td
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1.3228 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 518.2299 580.0818 cm
BT
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1 TL
-0.0059 Tc
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(2,3)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 527.5275 576.0566 cm
BT
/F2 1 Tf
1 TL
-0.0044 Tc
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(,)Tj
0.4913 0 Td
(Rob)Tj
-36.8818 -1.222 Td
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1.3228 0 Td
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1.9213 0 Td
(Dam)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 248.485 569.0834 cm
BT
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1 TL
-0.0059 Tc
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(12,186)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 268.8377 565.0582 cm
BT
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1 TL
-0.0044 Tc
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(,)Tj
0.4976 0 Td
(W.)Tj
1.4362 0 Td
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3.2882 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 365.4425 569.0834 cm
BT
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1 TL
-0.0059 Tc
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(187)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 376.4976 565.0582 cm
BT
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1 TL
-0.0044 Tc
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(,)Tj
0.4976 0 Td
(Xiaofeng)Tj
4.4094 0 Td
(Zhu)Tj
ET
Q
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1 j
1 J
0 w
6.7498 0 0 5.9992 437.1023 569.0834 cm
BT
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1 TL
-0.0059 Tc
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(71)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 444.5291 565.0582 cm
BT
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1 TL
-0.0044 Tc
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(,)Tj
0.4976 0 Td
(Dennis)Tj
3.5212 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 241.0582 558.085 cm
BT
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1 TL
-0.0059 Tc
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ET
Q
q
1 j
1 J
0 w
9 0 0 9 261.411 554.0598 cm
BT
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1 TL
-0.0044 Tc
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0.4976 0 Td
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3.6787 0 Td
(Fornage)Tj
ET
Q
q
1 j
1 J
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6.7498 0 0 5.9992 334.2047 558.085 cm
BT
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1 TL
-0.0059 Tc
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(18,19)Tj
ET
Q
q
1 j
1 J
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9 0 0 9 350.8724 554.0598 cm
BT
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0.4976 0 Td
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ET
Q
q
1 j
1 J
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6.7498 0 0 5.9992 428.5984 558.085 cm
BT
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1 TL
-0.0059 Tc
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(17)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 435.9685 554.0598 cm
BT
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-0.0044 Tc
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0.4976 0 Td
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1.1024 0 Td
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ET
Q
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1 j
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6.7498 0 0 5.9992 526.2236 558.085 cm
BT
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-0.0059 Tc
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ET
Q
q
1 j
1 J
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9 0 0 9 546.5763 554.0598 cm
BT
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ET
Q
q
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6.7498 0 0 5.9992 262.3748 547.0299 cm
BT
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1 TL
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(102)Tj
ET
Q
q
1 j
1 J
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9 0 0 9 273.4299 543.0614 cm
BT
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0.4976 0 Td
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ET
Q
q
1 j
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6.7498 0 0 5.9992 328.9322 547.0299 cm
BT
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(190)Tj
ET
Q
q
1 j
1 J
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9 0 0 9 340.044 543.0614 cm
BT
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-0.0044 Tc
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0.4976 0 Td
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4.1827 0 Td
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ET
Q
q
1 j
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6.7498 0 0 5.9992 419.244 547.0299 cm
BT
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(14)Tj
ET
Q
q
1 j
1 J
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9 0 0 9 426.6141 543.0614 cm
BT
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4.1827 0 Td
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ET
Q
q
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6.7498 0 0 5.9992 520.3275 547.0299 cm
BT
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(13)Tj
ET
Q
q
1 j
1 J
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9 0 0 9 527.6976 543.0614 cm
BT
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ET
Q
q
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6.7498 0 0 5.9992 247.6913 536.0314 cm
BT
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ET
Q
q
1 j
1 J
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9 0 0 9 280.97 532.0629 cm
BT
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ET
Q
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6.7498 0 0 5.9992 346.6771 536.0314 cm
BT
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ET
Q
q
1 j
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9 0 0 9 368.9007 532.0629 cm
BT
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ET
Q
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6.7498 0 0 5.9992 458.4755 536.0314 cm
BT
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(191)Tj
ET
Q
q
1 j
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9 0 0 9 469.5874 532.0629 cm
BT
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ET
Q
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6.7498 0 0 5.9992 534.3307 536.0314 cm
BT
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(192)Tj
ET
Q
q
1 j
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9 0 0 9 545.4425 532.0629 cm
BT
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ET
Q
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6.7498 0 0 5.9992 256.422 525.033 cm
BT
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(125)Tj
ET
Q
q
1 j
1 J
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9 0 0 9 271.2188 521.0645 cm
BT
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ET
Q
q
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6.7498 0 0 5.9992 356.485 525.033 cm
BT
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(18)Tj
ET
Q
q
1 j
1 J
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9 0 0 9 367.5401 521.0645 cm
BT
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ET
Q
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1 J
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6.7498 0 0 5.9992 417.6566 525.033 cm
BT
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1 TL
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(166)Tj
ET
Q
q
1 j
1 J
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9 0 0 9 432.4535 521.0645 cm
BT
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ET
Q
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1 j
1 J
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6.7498 0 0 5.9992 506.6645 525.033 cm
BT
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ET
Q
q
1 j
1 J
0 w
9 0 0 9 523.3322 521.0645 cm
BT
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1.2095 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 243.1559 514.0346 cm
BT
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1 TL
-0.0059 Tc
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(6,73)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 259.8236 510.0661 cm
BT
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-0.0044 Tc
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4.1764 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 329.5559 514.0346 cm
BT
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1 TL
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(4)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 336.9826 510.0661 cm
BT
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-0.0044 Tc
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3.8551 0 Td
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1.2095 0 Td
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ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 424.6299 514.0346 cm
BT
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1 TL
-0.0059 Tc
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(1)Tj
ET
Q
q
1 j
1 J
0 w
9 0 0 9 432 510.0661 cm
BT
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-0.0044 Tc
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3.1874 0 Td
(Levy)Tj
ET
Q
q
1 j
1 J
0 w
6.7498 0 0 5.9992 485.4614 514.0346 cm
BT
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1 TL
-0.0059 Tc
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(189,193)Tj
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( \r)Tj
ET
Q
q
1 j
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