README file for Figure_1_Source_Data - Meta-analysis of animal models of NAFLD Contact: Jake Mann, Institute of Metabolic Science, Cambridge, UK jm2032@cam.ac.uk Data used in the anlaysis from https://doi.org/10.7554/eLife.56573 Derived from a systematic review of rodent models of NAFLD. Data representes the raw data used in the meta-analysis. Search completed January 2019. Data updated August 2020. The dataset is a single tab in a .xlsx file. The data is free to use with no restrictions. Full description of the analysis, methods, and processing of the data are available at: https://doi.org/10.7554/eLife.56573 Variable list: ID - Unique ID for each paper Study - First author surname and year of publation Title of Paper - Publication title Models - Full description of the NAFLD model used Model_simple - Simplified version of the NAFLD model Background - Full genetic background of animals used (where stated) Background_simple - Simplified genetic background Protocol - Presence (1) or absence (0) of a pre-specified protocol Randomisation - Presence (1) or absence (0) of randomisation Blinding - Presence (1) or absence (0) of blinding used Power_calculation - Presence (1) or absence (0) of a power calculation Qual_score - Sum (0-4) of the previous four 'study quality' variables Chol_per - Percentage of cholesterol (% weight) in diet, where applicable FructGluc_per - Percentage of fructose-glucose (% weight) in diet, where applicable [including in water] Sucr_kcal - Percentage of sucrose (% kcal) in diet, where applicable [not including in water] Fat_kcal - Percentage of fat (% kcal) in diet, where applicable Sex - Sex of animals used: M (male), F (female), or both Paper - Unique code for each cohort, within each paper. Where a paper describes more than one cohort (one row in the database), the code is "Surname Year _n" where n is the number of the cohort for each paper Intervention - The interventional drug used in this cohort Drug_dose - Numerical drug dose for the intervention, where it can be summarised Unit - Units for the drug dose Drug dose (long) - Full description of the drug dose Indiv_drug_class_3 - Classification of intervention by individual drug Drug_Class_new_1_all - Classification of intervention by pharmacological class Age_start - Age (in months) interventional drug was started Duration - Duration (in weeks) of interventional drug Age_end - Age (in months) of end of interventional study Wt_Int - Mean weight (in grams) of interventional group at the end of the study Wt_Pla - Mean weight (in grams) of placebo/control group at the end of the study Wt_change - Relative difference in weight at the end of the study (interventional/control) Gluc_Int - Mean glucose (mmol/L) of interventional group at the end of the study Gluc_Pla - Mean glucose (mmol/L) of placebo/control group at the end of the study Gluc_change - Relative difference in glucose at the end of the study (interventional/control) Insul_Int - Mean insulin (pmol/L) of interventional group at the end of the study Insul_Pla - Mean insulin (pmol/L) of placebo/control group at the end of the study Insul_change - Relative difference in insulin at the end of the study (interventional/control) TG_Int_Mean_abs - Mean hepatic triglyceride content (micromol/mg) in interventional group TG_Int_SD_abs - Standard deviation in hepatic triglyceride content (micromol/mg) in interventional group TG_Int_size - Size of internvetional group for hepatic triglyceride content TG_Pla_Mean_abs - Mean hepatic triglyceride content (micromol/mg) in control/placebo group TG_Pla_SD_abs - Standard deviation in hepatic triglyceride content (micromol/mg) in control/placebo group TG_Pla_size - Size of control/placebo group for hepatic triglyceride content Stea_Int_Mean - Mean steatosis grade [0-3] in interventional group Stea_Int_SD - Standard deviation in steatosis grade [0-3] in interventional group Stea_Int_size - Size of internvetional group for steatosis grade Stea_Pla_Mean - Mean steatosis grade [0-3] in control/placebo group Stea_Pla_SD - Standard deviation in steatosis grade [0-3] in control/placebo group Stea_Pla_size - Size of control/placebo group for steatosis grade LobIn_Int_Mean - Mean lobular inflammation [0-3] in interventional group LobIn_Int_SD - Standard deviation in lobular inflammation [0-3] in interventional group LobIn_Int_size - Size of internvetional group for lobular inflammation LobIn_Pla_Mean - Mean lobular inflammation [0-3] in control/placebo group LobIn_Pla_SD - Standard deviation in lobular inflammation [0-3] in control/placebo group LobIn_Pla_size - Size of control/placebo group for lobular inflammation Portal_Int_Mean - Mean portal inflammation [0-2] in interventional group Portal_Int_SD - Standard deviation in portal inflammation [0-2] in interventional group Portal_Int_size - Size of internvetional group for portal inflammation Portal_Pla_Mean - Mean portal inflammation [0-2] in control/placebo group Portal_Pla_SD - Standard deviation in portal inflammation [0-2] in control/placebo group Portal_Pla_size - Size of control/placebo group for portal inflammation Bal_Int_Mean - Mean hepatocellular ballooning [0-2] in interventional group Bal_Int_SD - Standard deviation in hepatocellular ballooning [0-2] in interventional group Bal_Int_size - Size of internvetional group for hepatocellular ballooning Bal_Pla_Mean - Mean hepatocellular ballooning [0-2] in control/placebo group Bal_Pla_SD - Standard deviation in hepatocellular ballooning [0-2] in control/placebo group Bal_Pla_size - Size of control/placebo group for hepatocellular ballooning Fib_Int_Mean - Mean fibrosis stage [0-4] in interventional group Fib_Int_SD - Standard deviation in fibrosis stage [0-4] in interventional group Fib_Int_size - Size of internvetional group for fibrosis stage Fib_Pla_Mean - Mean fibrosis stage [0-4] in control/placebo group Fib_Pla_SD - Standard deviation in fibrosis stage [0-4] in control/placebo group Fib_Pla_size - Size of control/placebo group for fibrosis stage NAS_Int_Mean - Mean NAFLD Activity Score (NAS, 0-9) in interventional group NAS_Int_SD - Standard deviation in NAFLD Activity Score (NAS, 0-9) in interventional group NAS_Int_size - Size of internvetional group for NAFLD Activity Score (NAS) NAS_Pla_Mean - Mean NAFLD Activity Score (NAS, 0-9) in control/placebo group NAS_Pla_SD - Standard deviation in NAFLD Activity Score (NAS, 0-9) in control/placebo group NAS_Pla_size - Size of control/placebo group for NAFLD Activity Score (NAS) TG_Int_Mean - Hepatic triglyceride content in interventional group relative to placebo (interventional/control) TG_Int_SD - Relative standard deviation in hepatic triglyceride content in interventional group TG_Pla_Mean - Hepatic triglyceride content in control group relative to placebo (interventional/control) TG_Pla_SD - Relative standard deviation in hepatic triglyceride content in control group