Now showing items 1-6 of 6

    • Further developments towards a genome-scale metabolic model of yeast 

      Dobson, Paul D; Smallbone, Kieran; Jameson, Daniel; Simeonidis, Evangelos; Lanthaler, Karin; Pir, Pinar; Lu, Chuan et al. (2010-10-28)
      Abstract Background To date, several genome-scale network reconstructions have been used to describe the metabolism of the yeast Saccharomyces cerevisiae, each differing in scope and content. The recent community-driven ...
    • The genetic control of growth rate: a systems biology study in yeast. 

      Pir, Pinar; Gutteridge, Alex; Wu, Jian; Rash, Bharat; Kell, Douglas B; Zhang, Nianshu; Oliver, Stephen George (2012-01-13)
      Abstract Background Control of growth rate is mediated by tight regulation mechanisms in all free-living organisms since long-term survival depends on adaptation to diverse environmental conditions. The yeast, Saccharomyces ...
    • Genome-wide assessment of the carriers involved in the cellular uptake of drugs: a model system in yeast. 

      Lanthaler, Karin; Bilsland, Elizabeth; Dobson, Paul D; Moss, Harry J; Pir, Pinar; Kell, Douglas B; Oliver, Stephen George (2011-10-24)
      Abstract Background The uptake of drugs into cells has traditionally been considered to be predominantly via passive diffusion through the bilayer portion of the cell membrane. The recent recognition that drug uptake is ...
    • Growth control of the eukaryote cell: A systems biology study in yeast 

      Castrillo, Juan Ignacio; Zeef, Leo A; Hoyle, David C; Zhang, Nianshu; Hayes, Andrew; Gardner, David CJ; Cornell, Michael J et al. (2007-04-30)
      Abstract Background Cell growth underlies many key cellular and developmental processes, yet a limited number of studies have been carried out on cell-growth regulation. Comprehensive studies at the transcriptional, proteomic ...
    • Information management for high content live cell imaging 

      Jameson, Daniel; Turner, David Andrew; Ankers, John; Kennedy, Stephnie; Ryan, Sheila; Swainston, Neil; Griffiths, Tony et al. (2009-07-21)
      Abstract Background High content live cell imaging experiments are able to track the cellular localisation of labelled proteins in multiple live cells over a time course. Experiments using high content live cell imaging ...
    • Performing statistical analyses on quantitative data in Taverna workflows: an example using R and maxdBrowse to identify differentially-expressed genes from microarray data 

      Li, Peter; Castrillo, Juan Ignacio; Velarde, Giles; Wassink, Ingo; Soiland-Reyes, Stian; Owen, Stuart; Withers, David et al. (2008-08-07)
      Abstract Background There has been a dramatic increase in the amount of quantitative data derived from the measurement of changes at different levels of biological complexity during the post-genomic era. However, there are ...