Now showing items 1-2 of 2

    • Application of phage display to high throughput antibody generation and characterisation 

      Schofield, Darren J; Pope, Anthony R; Clementel, Veronica; Buckell, Jenny; Chapple, Susan DJ; Clarke, Kay F; Conquer, Jennie S et al. (2007-11-29)
      Abstract We have created a high quality phage display library containing over 1010 human antibodies and describe its use in the generation of antibodies on an unprecedented scale. We have selected, screened and sequenced ...
    • Deficient methylation and formylation of mt-tRNA$^{Met}$ wobble cytosine in a patient carrying mutations in NSUN3 

      Van, Haute Lindsey; Dietmann, Sabine; Kremer, Laura; Hussain, Shobbir; Pearce, Sarah F; Powell, Christopher A; Rorbach, Joanna et al. (Nature Publishing Group, 2016-06-30)
      Epitranscriptome modifications are required for structure and function of RNA and defects in these pathways have been associated with human disease. Here we identify the RNA target for the previously uncharacterized ...