Now showing items 1-3 of 3

    • Citrullination regulates pluripotency and histone H1 binding to chromatin 

      Christophorou, Maria A.; Castelo-Branco, Gonçalo; Halley-Stott, Richard P.; Oliveira, Clara Slade; Loos, Remco; Radzisheuskaya, Aliaksandra; Mowen, Kerri A. et al. (Nature Publishing Group, 2014-01-26)
      Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline [1] . This modification leads to the loss of a positive charge and reduction in hydrogen ...
    • Differential expression of selected histone modifier genes in human solid cancers 

      Ozdag, Hilal; Teschendorff, Andrew E.; Ahmed, Ahmed A.; Hyland, Sarah J.; Blenkiron, Cherie; Bobrow, Linda; Veerakumarasivam, Abhi et al. (2006-04-25)
      Abstract Background Post-translational modification of histones resulting in chromatin remodelling plays a key role in the regulation of gene expression. Here we report characteristic patterns of expression of 12 members ...
    • Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes 

      Murata, Kazutaka; Kouzarides, Tony; Bannister, Andrew J.; Gurdon, John (2010-02-04)
      Abstract Background When the nuclei of mammalian somatic cells are transplanted to amphibian oocytes in the first meiotic prophase, they are rapidly induced to begin transcribing several pluripotency genes, including Sox2 ...