Now showing items 1-6 of 6

    • BET protein inhibition shows efficacy against JAK2V617F driven neoplasms 

      Wyspiańska, BS; Bannister, Andrew John; Barbieri, Isaia; Nangalia, Jyoti; Godfrey, Anna Louise; Calero-Nieto, Fernando Jose; Robson, Samuel Charles et al. (Nature Publishing Group, 2013-09-06)
      Small molecule inhibition of the BET family of proteins, which bind acetylated lysines within histones, has been shown to have a marked therapeutic benefit in pre-clinical models of MLL-fusion protein driven leukemias. ...
    • Citrullination regulates pluripotency and histone H1 binding to chromatin 

      Christophorou, Maria A; Castelo-Branco, Gonçalo; Halley-Stott, Richard P; Oliveira, Clara Slade; Loos, Remco; Radzisheuskaya, Aliaksandra; Mowen, Kerri A et al. (Nature Publishing Group, 2014-01-26)
      Citrullination is the post-translational conversion of an arginine residue within a protein to the non-coded amino acid citrulline [1] . This modification leads to the loss of a positive charge and reduction in hydrogen ...
    • Differential expression of selected histone modifier genes in human solid cancers 

      Ozdag, Hilal; Teschendorff, Andrew E; Ahmed, Ahmed A; Hyland, Sarah J; Blenkiron, Cherie; Bobrow, Linda; Veerakumarasivam, Abhi et al. (2006-04-25)
      Abstract Background Post-translational modification of histones resulting in chromatin remodelling plays a key role in the regulation of gene expression. Here we report characteristic patterns of expression of 12 members ...
    • Genomic positional conservation identifies topological anchor point RNAs linked to developmental loci 

      Amaral, Paulo P; Leonardi, Tommaso; Han, Namshik; Viré, Emmanuelle; Gascoigne, Dennis K; Arias-Carrasco, Raúl; Büscher, Magdalena et al. (2018-03-15)
      Abstract Background The mammalian genome is transcribed into large numbers of long noncoding RNAs (lncRNAs), but the definition of functional lncRNA groups has proven difficult, ...
    • Histone H3 lysine 4 methylation is associated with the transcriptional reprogramming efficiency of somatic nuclei by oocytes 

      Murata, Kazutaka; Kouzarides, Tony; Bannister, Andrew John; Gurdon, John (2010-02-04)
      Abstract Background When the nuclei of mammalian somatic cells are transplanted to amphibian oocytes in the first meiotic prophase, they are rapidly induced to begin transcribing several pluripotency genes, including Sox2 ...
    • Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control. 

      Barbieri, Isaia; Tzelepis, Konstantinos; Pandolfini, Luca; Shi, Junwei; Millán-Zambrano, Gonzalo; Robson, Samuel C; Aspris, Demetrios et al. (Springer Nature, 2017-12)
      N6-methyladenosine (m6A) is an abundant internal RNA modification in both coding and non-coding RNAs, catalysed by the METTL3/METTL14 methyltransferase complex. Here we define a novel pathway specific for METTL3, implicated ...