Now showing items 1-10 of 10

    • The Autism-Spectrum Quotient (AQ) in siblings of people with autism 

      Ruzich, Emily; Allison, Carrie; Smith, Paula; Ring, Howard; Auyeung, Bonnie; Baron-Cohen, Simon (Wiley, 2016)
      This study measures the distribution of autistic traits, using the Autism-Spectrum Quotient (AQ), in siblings of individuals with autism spectrum conditions (ASC). Total AQ scores, along with AQ subscales, were collected ...
    • BRCA1and BRCA2mutation predictions using the BOADICEA and BRCAPRO models and penetrance estimation in high-risk French-Canadian families 

      Antoniou, Antonis C.; Francine, Durocher; Smith, Paula; Simard, Jacques; Easton, Douglas F. (2005-12-12)
      Abstract Introduction Several genetic risk models for breast and ovarian cancer have been developed, but their applicability to specific populations has not been evaluated. We used data from French-Canadian families to ...
    • Common variation in EMSYand risk of breast and ovarian cancer: a case-control study using HapMap tagging SNPs 

      Benusiglio, Patrick R.; Lesueur, Fabienne; Luccarini, Craig; McIntosh, Joan; Luben, Robert; Smith, Paula; Dunning, Alison M. et al. (2005-07-19)
      Abstract Background EMSY could be involved in low-level susceptibility to breast and ovarian cancer. Gene amplification is seen in a proportion of breast and ovarian tumours and correlates with poor prognosis in breast ...
    • A comprehensive meta-analysis of common genetic variants in Autism Spectrum Conditions 

      Warrier, Varun; Chee, Vivienne; Smith, Paula; Chakrabarti, Bhismadev; Baron-Cohen, Simon (2015-08-20)
      Background: Autism Spectrum Conditions (ASC) are a group of neurodevelopmental conditions characterized by difficulties in social interaction and communication alongside repetitive and stereotyped behaviours. ASC are ...
    • Measuring autistic traits in the general population: a systematic review of the Autism-Spectrum Quotient (AQ) in a nonclinical population sample of 6,900 typical adult males and females 

      Ruzich, E.; Allison, Carrie; Smith, Paula; Watson, Peter; Auyeung, Bonnie; Ring, Howard; Baron-Cohen, Simon (BioMed Central, 2015-01-14)
      The Autism-Spectrum Quotient (AQ) is a self-report measure of autistic traits. It is frequently cited in diverse fields and has been administered to adults of at least average intelligence with autism and to nonclinical ...
    • Novel associations between common breast cancer susceptibility variants and risk-predicting mammographic density measures 

      Stone, Jennifer; Thompson, Deborah J; dos Santos Silva, Isabel; Scott, Christopher; Tamimi, Rulla M.; Lindstrom, Sara; Kraft, Peter et al. (American Association for Cancer Research, 2015-04-10)
      Mammographic density measures adjusted for age and body mass index (BMI) are heritable predictors of breast cancer risk but few mammographic density-associated genetic variants have been identified. Using data for 10,727 ...
    • The “Reading the Mind in the Eyes” test: Complete absence of typical sex difference in ~400 men and women with autism 

      Baron-Cohen, Simon; Bowen, Daniel C.; Holt, Rosemary J.; Allison, Carrie; Auyeung, Bonnie; Lombardo, Michael V.; Smith, Paula et al. (PLoS, 2015)
      The “Reading the Mind in the Eyes” test (Eyes test) is an advanced test of theory of mind. Typical sex difference has been reported (i.e., female advantage). Individuals with autism show more difficulty than do typically ...
    • Sex and STEM occupation predict Autism-Spectrum Quotient (AQ) scores in half a million people 

      Ruzich, Emily; Allison, Carrie; Chakrabarti, Bhismadev; Smith, Paula; Musto, Henry; Ring, Howard; Baron-Cohen, Simon (PLoS, 2015-10-21)
      This study assesses Autism-Spectrum Quotient (AQ) scores in a ‘big data’ sample collected through the UK Channel 4 television website, following the broadcasting of a medical education program. We examine correlations ...
    • Subgrouping siblings of people with autism: identifying the broader autism phenotype 

      Ruzich, Emily; Allison, Carrie; Smith, Paula; Watson, Peter; Auyeung, Bonnie; Ring, Howard; Baron-Cohen, Simon (Wiley, 2015-09-02)
      We investigate the broader autism phenotype (BAP) in siblings of individuals with autism spectrum conditions (ASC). Autistic traits were measured in typical controls (n = 2,000), siblings (n = 496), and volunteers with ASC ...
    • The androgen receptor CAG repeat polymorphism and modification of breast cancer risk in BRCA1and BRCA2mutation carriers 

      Spurdle, Amanda B.; Antoniou, Antonis C.; Duffy, David L.; Pandeya, Nirmala; Kelemen, Livia; Chen, Xiaoqing; Peock, Susan et al. (2004-12-16)
      Abstract Introduction The androgen receptor (AR) gene exon 1 CAG repeat polymorphism encodes a string of 9–32 glutamines. Women with germline BRCA1 mutations who carry at least one AR allele with 28 or more repeats have ...