Now showing items 1-4 of 4

    • Epithelial calcineurin controls microbiota-dependent intestinal tumor development 

      Peuker, Kenneth; Muff, Stefanie; Wang, Jun; Künzel, Sven; Bosse, Esther; Zeissig, Yvonne; Luzzi, Giuseppina et al. (Nature Publishing Group, 2016-04-04)
      Inflammation-associated pathways are active in intestinal epithelial cells (IECs) and contribute to the pathogenesis of colorectal cancer (CRC). Calcineurin, a phosphatase required for the activation of the nuclear factor ...
    • Lipocalin 2 Protects from Inflammation and Tumorigenesis Associated with Gut Microbiota Alterations 

      Moschen, Alexander R.; Gerner, Romana R.; Wang, Jun; Klepsch, Victoria; Adolph, Timon E.; Reider, Simon J.; Hackl, Hubert et al. (Elsevier, 2016-04-13)
      High mucosal and fecal concentrations of the antimicrobial siderophore-binding peptide Lipocalin-2 (Lcn2) are observed in inflammatory bowel disease. However, Lcn2 function in chronic intestinal inflammation remains unclear. ...
    • Porcine transcriptome analysis based on 97 non-normalized cDNA libraries and assembly of 1,021,891 expressed sequence tags 

      Gorodkin, Jan; Cirera, Susanna; Hedegaard, Jakob; Gilchrist, Michael J.; Panitz, Frank; Jorgensen, Claus B.; Scheibye-Knudsen, Karsten et al. (2007-04-02)
      Background Knowledge of the structure of gene expression is essential for mammalian transcriptomics research. We analyzed a collection of more than one million porcine expressed sequence tags (ESTs), of which two-thirds ...
    • Tumor Necrosis Factor Receptor 2-Signaling in CD133-Expressing Cells in Renal Clear Cell Carcinoma 

      Al-Lamki, Rafia S.; Wang, Jun; Yang, Jun; Burrows, Natalie; Maxwell, Patrick H.; Eisen, Timothy; Warren, Anne Y. et al. (Impact Journals, 2016)
      Compared to normal kidney, renal clear cell carcinomas (ccRCC) contain increased numbers of interstitial, non-hematopoietic CD133+cells that express stem cell markers and exhibit low rates of proliferation. These cells ...