Now showing items 2-10 of 10

    • A Genome-Wide Association Study for Regulators of Micronucleus Formation in Mice 

      McIntyre, Rebecca E; Nicod, Jérôme; Robles-Espinoza, Carla Daniela; Maciejowski, John; Cai, Na; Hill, Jennifer; Verstraten, Ruth et al. (Genetics Society of America, 2016-05-27)
    • Genome-wide genetic screening with chemically mutagenized haploid embryonic stem cells 

      Forment, Josep; Herzog, Mareike; Coates, Julia; Konopka, Tomasz; Gapp, Bianca V; Nijman, Sebastian M; Adams, David J et al. (Nature Publishing Group, 2016-10-31)
      In model organisms, classical genetic screening via random mutagenesis provides key insights into the molecular bases of genetic interactions, helping to define synthetic lethality, synthetic viability and drug-resistance ...
    • Germline TERT promoter mutations are rare in familial melanoma 

      Harland, Mark; Petljak, Mia; Robles-Espinoza, Carla Daniela; Ding, Zhihao; Gruis, Nelleke A; van, Doorn Remco; Pooley, Karen Anne et al. (Springer, 2015-10-03)
    • A high-throughput in vivo micronucleus assay for genome instability screening in mice 

      Balmus, Gabriel; Karp, Natasha A; Ng, Bee Ling; Jackson, Stephen Philip; Adams, David J; McIntyre, Rebecca E (Nature Publishing Group, 2014-12-31)
    • A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression 

      Giotopoulos, George; van, der Weyden Louise; Osaki, Hikari; Rust, Alistair G; Gallipoli, Paolo; Meduri, Eshwar; Horton, Sarah Jayne et al. (Rockefeller University Press, 2015-08-24)
      The introduction of highly selective ABL-tyrosine kinase inhibitors (TKIs) has revolutionized therapy for chronic myeloid leukemia (CML). However, TKIs are only efficacious in the chronic phase of the disease and effective ...
    • POT1 loss-of-function variants predispose to familial melanoma 

      Robles-Espinoza, Carla Daniela; Harland, Mark; Ramsay, Andrew J; Aoude, Lauren G; Quesada, Víctor; Ding, Zhizhao; Pooley, Karen Anne et al. (NPG, 2014-03-30)
    • Somatic drivers of B-ALL in a model of ETV6-RUNX1; Pax5 +/− leukemia 

      van, der Weyden Louise; Giotopoulos, George; Wong, Kim; Rust, Alistair G; Robles-Espinoza, Carla D; Osaki, Hikari; Huntly, Brian James et al. (2015-08-13)
      BACKGROUND: B-cell precursor acute lymphoblastic leukemia (B-ALL) is amongst the leading causes of childhood cancer-related mortality. Its most common chromosomal aberration is the ETV6-RUNX1 fusion gene, with ~25% of ...
    • Synthetic lethality between PAXX and XLF in mammalian development 

      Balmus, Gabriel; Barros, Ana C; Wijnhoven, Paul WG; Lescale, Chloé; Hasse, Hélène Lenden; Boroviak, Katharina; le, Sage Carlos et al. (Cold Spring Harbor Laboratory Press, 2016-10-01)
    • Synthetic-viability genomic screening defines Sae2 function in DNA repair 

      Puddu, Fabio; Oelschlaegel, Tobias; Guerini, Ilaria; Geisler, Nicola J; Niu, Hengyao; Herzog, Mareike; Salguero, Israel et al. (Wiley-VCH Verlag, EMBO, 2015-04-21)