Now showing items 2-4 of 4

    • Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling 

      Naderi, Ali; Ahmed, Ahmed A.; Barosa-Morais, Nuno L.; Aparicio, Samuel; Brenton, James D.; Caldas, Carlos (2004-01-30)
      Abstract Background Expression microarrays have evolved into a powerful tool with great potential for clinical application and therefore reliability of data is essential. RNA amplification is used when the amount of starting ...
    • The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes 

      Pereira, Bernard; Chin, Suet-Feung; Rueda, Oscar M.; Vollan, Hans-Kristian Moen; Provenzano, Elena; Bardwell, Helen A.; Pugh, Michelle et al. (Nature Publishing Group, 2016-05-10)
      The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumours that have ...
    • The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent 

      Prentice, Leah M.; d'Anglemont de Tassigny, Xavier; McKinney, Steven; Ruiz de Algara, Teresa; Yap, Damian; Turashvili, Gulisa; Poon, Steven et al. (2011-04-28)
      Abstract Background Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these ...