Now showing items 2-5 of 5

    • Expression microarray reproducibility is improved by optimising purification steps in RNA amplification and labelling 

      Naderi, Ali; Ahmed, Ahmed A; Barosa-Morais, Nuno L; Aparicio, Samuel; Brenton, James Derek; Caldas, Carlos Manuel (2004-01-30)
      Abstract Background Expression microarrays have evolved into a powerful tool with great potential for clinical application and therefore reliability of data is essential. RNA amplification is used when the amount of starting ...
    • The somatic mutation profiles of 2,433 breast cancers refine their genomic and transcriptomic landscapes 

      Pereira, Bernard; Chin, Suet Feung; Rueda, Oscar M; Vollan, Hans-Kristian Moen; Provenzano, Elena; Bardwell, Helen A; Pugh, Michelle et al. (Nature Publishing Group, 2016-05-10)
      The genomic landscape of breast cancer is complex, and inter- and intra-tumour heterogeneity are important challenges in treating the disease. In this study, we sequence 173 genes in 2,433 primary breast tumours that have ...
    • The testosterone-dependent and independent transcriptional networks in the hypothalamus of Gpr54 and Kiss1 knockout male mice are not fully equivalent 

      Prentice, Leah M; d'Anglemont, Xavier Bernard; McKinney, Steven; Ruiz, de Algara Teresa; Yap, Damian; Turashvili, Gulisa; Poon, Steven et al. (2011-04-28)
      Abstract Background Humans and mice with loss of function mutations in GPR54 (KISS1R) or kisspeptin do not progress through puberty, caused by a failure to release GnRH. The transcriptional networks regulated by these ...
    • A tumor DNA complex aberration index is an independent predictor of survival in breast and ovarian cancer. 

      Vollan, Hans Kristian Moen; Rueda, Oscar M; Chin, Suet Feung; Curtis, Christina; Turashvili, Gulisa; Shah, Sohrab; Lingjærde, Ole Christian et al. (2015-01)