Now showing items 1-5 of 5

    • Activation of K-RAS by co-mutation of codons 19 and 20 is transforming 

      Naguib, Mark Johan; Wilson, Catherine Helen; Adams, David J; Arends, Mark J (2011-03-03)
      Abstract The K-RAS oncogene is widely mutated in human cancers. Activating mutations in K-RAS give rise to constitutive signalling through the MAPK/ERK and PI3K/AKT pathways promoting increased cell division, reduced ...
    • Boosting Wnt activity during colorectal cancer progression through selective hypermethylation of Wnt signaling antagonists 

      Silva, Ana-Luisa; Dawson, Sarah Natalie; Arends, Mark J; Guttula, Kiran; Hall, Nigel; Cameron, Ewen A; Huang, Tim H-M et al. (BioMed Central, 2014-11-29)
      Background: There is emerging evidence that Wnt pathway activity may increase during the progression from colorectal adenoma to carcinoma and that this increase is potentially an important step towards the invasive ...
    • Familial adrenocortical carcinoma in association with Lynch syndrome 

      Challis, Benjamin George; Kandasamy, Narayanan; Powlson, Andrew; Koulouri, Olympia; Annamalai, Anand Kumar; Happerfield, Lisa; Marker, Alison J et al. (Endocrine Society, 2016-05-04)
      Context: Adrenocortical carcinoma (ACC) is a rare endocrine malignancy with a poor prognosis. Although the majority of childhood ACC arises in the context of inherited cancer susceptibility syndromes, it remains less clear ...
    • Mouse models of colorectal cancer as preclinical models 

      McIntyre, Rebecca E; Buczacki, Simon James; Arends, Mark J; Adams, David J (Cancer Research UK Cambridge Institute, University of Cambridge, 2015-06-26)
      In this review, we discuss the application of mouse models to the identification and pre-clinical validation of novel therapeutic targets in colorectal cancer, and to the search for early disease biomarkers. Large-scale ...
    • Multilocus Inherited Neoplasia Alleles Syndrome (MINAS): Case Series and Literature Review 

      Whitworth, James; Skytte, Anne-Bine; Sunde, Lone; Lim, Derek H; Arends, Mark J; Happerfield, Lisa; Frayling, Ian M et al. (American Medical Association, 2015-12-10)
      Mendelian causes of inherited cancer susceptibility are mostly rare and characterized by variable expression and incomplete penetrance. Phenotypic variability may result from a range of causes including locus heterogeneity, ...