Now showing items 3-11 of 11

    • FlyMine: an integrated database for Drosophila and Anopheles genomics 

      Lyne, Rachel; Smith, Richard; Rutherford, Kim; Wakeling, Matthew; Varley, Andrew; Guillier, Francois; Janssens, Hilde et al. (2007-07-05)
      Abstract FlyMine is a data warehouse that addresses one of the important challenges of modern biology: how to integrate and make use of the diversity and volume of current biological data. Its main focus is genomic and ...
    • Integrating phenotype ontologies across multiple species 

      Mungall, Christopher J.; Gkoutos, Georgios V.; Smith, Cynthia L.; Haendel, Melissa A.; Lewis, Suzanna E.; Ashburner, Michael (2010-01-08)
      Abstract Phenotype ontologies are typically constructed to serve the needs of a particular community, such as annotation of genotype-phenotype associations in mouse or human. Here we demonstrate how these ontologies can ...
    • Molecular characterization of the singed wingslocus of Drosophila melanogaster 

      Schwartz, Yuir B.; Boykova, Tatiana V.; Belyaeva, Elena S.; Ashburner, Michael; Zhimulev, Igor (2004-06-09)
      Abstract Background Hormones frequently guide animal development via the induction of cascades of gene activities, whose products further amplify an initial hormonal stimulus. In Drosophila the transformation of the larva ...
    • Principles of genome evolution in the Drosophila melanogaster species group. 

      Ranz, J. M.; Maurin, D.; Chan, Y. S.; von Grotthuss, M.; Hillier, L. W.; Roote, John; Ashburner, Michael et al. (Public Library of Science, 2007-06-05)
      The organization of genes on chromosomes changes over evolutionary time. In some organisms, such as fruit flies and mosquitoes, inversions of chromosome regions are widespread. This has been associated with adaptation ...
    • Recurrent insertion and duplication generate networks of transposable element sequences in the Drosophila melanogastergenome 

      Bergman, Casey M.; Quesneville, Hadi; Anxolabehere, Dominique; Ashburner, Michael (2006-11-29)
      Abstract Background The recent availability of genome sequences has provided unparalleled insights into the broad-scale patterns of transposable element (TE) sequences in eukaryotic genomes. Nevertheless, the difficulties ...
    • The ribosomal protein genes and Minuteloci of Drosophila melanogaster 

      Marygold, Steven J.; Roote, John; Reuter, Gunter; Lambertsson, Andrew; Ashburner, Michael; Millburn, Gillian; Harrison, Paul et al. (2007-10-10)
      Abstract Background Mutations in genes encoding ribosomal proteins (RPs) have been shown to cause an array of cellular and developmental defects in a variety of organisms. In Drosophila melanogaster, disruption of RP genes ...
    • The Sequence Ontology: a tool for the unification of genome annotations 

      Eilbeck, Karen; Lewis, Suzanna E.; Mungall, Christopher J.; Yandell, Mark D.; Stein, Lincoln; Durbin, Richard; Ashburner, Michael (2005-04-29)
      Abstract The Sequence Ontology (SO) is a structured controlled vocabulary for the parts of a genomic annotation. SO provides a common set of terms and definitions that will facilitate the exchange, analysis and management ...
    • The transposable elements of the Drosophila melanogaster euchromatin: a genomics perspective 

      Kaminker, Joshua S.; Bergman, Casey M.; Kronmiller, Brent; Carlson, Joseph; Svirskas, Robert; Patel, Sandeep; Frise, Erwin et al. (2002-12-23)
      Abstract Background Transposable elements are found in the genomes of nearly all eukaryotes. The recent completion of the Release 3 euchromatic genomic sequence of Drosophila melanogaster by the Berkeley Drosophila Genome ...
    • The transposable elements of the Drosophila melanogaster 

      Kaminker, Joshua S.; Bergman, Casey M.; Kronmiller, Brent; Carlson, Joseph; Svirskas, Robert; Patel, Sandeep; Frise, Erwin et al. (BioMed Central Ltd, 2002-12-23)
      Background: Transposable elements are found in the genomes of nearly all eukaryotes. The recent completion of the Release 3 euchromatic genomic sequence of Drosophila melanogaster by the Berkeley Drosophila Genome Project ...