Now showing items 3-10 of 10

• Evaluation of molecular brain changes associated with environmental stress in rodent models compared to human major depressive disorder: A proteomic systems approach. ﻿

(Taylor & Francis, 2016-11)
$\textbf{Objectives:}$ Rodent models of major depressive disorder (MDD) are indispensable when screening for novel treatments, but assessing their translational relevance with human brain pathology has proved difficult. ...
• Hippocampal proteomic and metabonomic abnormalities in neurotransmission, oxidative stress and apoptotic pathways in a chronic phencyclidine rat model ﻿

(American Chemical Society, 2015-06-04)
Schizophrenia is a neuropsychiatric disorder affecting 1% of the world’s population. Due to a broad range of symptoms and disease heterogeneity, current therapeutic approaches to treat schizophrenia fail to address all ...
• Metabolic changes in schizophrenia and human brain evolution ﻿

(2008-08-05)
Abstract Background Despite decades of research, the molecular changes responsible for the evolution of human cognitive abilities remain unknown. Comparative evolutionary studies provide detailed information about DNA ...
• The Potential of Immune Biomarkers to Advance Personalized Medicine Approaches for Schizophrenia ﻿

(Wolters Kluwer, 2015-05)
Molecular profiling studies have helped increase the understanding of the immune processes thought to be involved in the etiology and pathophysiology of psychiatric disorders such as schizophrenia. Current therapeutic ...
• Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients ﻿

(Elsevier, 2015-11-02)
Traditional schizophrenia pharmacotherapy remains a subjective trial and error process involving administration, titration and switching of drugs multiple times until an adequate response is achieved. Despite this ...
• Proteomic systems evaluation of the molecular validity of preclinical psychosis models compared to schizophrenia brain pathology ﻿

(Elsevier, 2016-06-19)
Pharmacological and genetic rodent models of schizophrenia play an important role in the drug discovery pipeline, but quantifying the molecular similarity of such models with the underlying human pathophysiology has proved ...
• Systematic analysis of gene expression in human brains before and after death ﻿

(2005-12-30)
Abstract Background Numerous studies have employed microarray techniques to study changes in gene expression in connection with human disease, aging and evolution. The vast majority of human samples available for research ...
• The application of selective reaction monitoring shows dysregulation of glycolysis in a preclinical model of schizophrenia ﻿

(2012-03-15)
Abstract Background Establishing preclinical models is essential for novel drug discovery in schizophrenia. Most existing models are characterized by abnormalities in behavioral readouts, which are informative, but do not ...