Now showing items 2-6 of 6

    • Metabolic changes in schizophrenia and human brain evolution 

      Khaitovich, Philipp; Lockstone, Helen E.; Wayland, Matthew T.; Tsang, Tsz M.; Jayatilaka, Samantha D.; Guo, Arfu J.; Zhou, Jie et al. (2008-08-05)
      Abstract Background Despite decades of research, the molecular changes responsible for the evolution of human cognitive abilities remain unknown. Comparative evolutionary studies provide detailed information about DNA ...
    • The Potential of Immune Biomarkers to Advance Personalized Medicine Approaches for Schizophrenia 

      Cox, David; Chan, Man K.; Bahn, Sabine (Wolters Kluwer, 2015-05)
      Molecular profiling studies have helped increase the understanding of the immune processes thought to be involved in the etiology and pathophysiology of psychiatric disorders such as schizophrenia. Current therapeutic ...
    • Pretreatment levels of the fatty acid handling proteins H-FABP and CD36 predict response to olanzapine in recent-onset schizophrenia patients 

      Tomasik, Jakub; Schwarz, Emanuel; Lago, Santiago G.; Rothermundt, Matthias; Leweke, F. Markus; van Beveren, Nico J. M.; Guest, Paul C. et al. (Elsevier, 2015-11-02)
      Traditional schizophrenia pharmacotherapy remains a subjective trial and error process involving administration, titration and switching of drugs multiple times until an adequate response is achieved. Despite this ...
    • Systematic analysis of gene expression in human brains before and after death 

      Franz, Henriette; Ullmann, Claudia; Becker, Albert; Ryan, Margaret; Bahn, Sabine; Arendt, Thomas; Simon, Matthias et al. (2005-12-30)
      Abstract Background Numerous studies have employed microarray techniques to study changes in gene expression in connection with human disease, aging and evolution. The vast majority of human samples available for research ...
    • The application of selective reaction monitoring shows dysregulation of glycolysis in a preclinical model of schizophrenia 

      Martins-de-Souza, Daniel; Alsaif, Murtada; Ernst, Agnes; Harris, Laura W.; Aerts, Nancy; Lenaerts, Ilse; Peeters, Pieter J. et al. (2012-03-15)
      Abstract Background Establishing preclinical models is essential for novel drug discovery in schizophrenia. Most existing models are characterized by abnormalities in behavioral readouts, which are informative, but do not ...