Now showing items 1-3 of 3

    • DOMINO-AD protocol: donepezil and memantine in moderate to severe Alzheimer's disease - a multicentre RCT 

      Jones, Rob; Sheehan, Bart; Phillips, Patrick; Juszczak, Ed; Adams, Jessica; Baldwin, Ashley; Ballard, Clive et al. (2009-07-24)
      Abstract Background Alzheimer's disease (AD) is the commonest cause of dementia. Cholinesterase inhibitors, such as donepezil, are the drug class with the best evidence of efficacy, licensed for mild to moderate AD, while ...
    • Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia 

      Alghamdi, Amani; Vallortigara, Julie; Howlett, David R; Broadstock, Martin; Hortobágyi, Tibor; Ballard, Clive; Thomas, Alan J et al. (IOS Press, 2017-03-21)
      Lewy body dementia is the second most common neurodegenerative dementia and is pathologically characterized by $\alpha$-synuclein positive cytoplasmic inclusions, with varying amounts of amyloid-$\beta$ (A$\beta$) and ...
    • Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias 

      Howlett, David R.; Whitfield, David; Johnson, Mary; Attems, Johannes; O’Brien, John T.; Aarsland, Dag; Lai, Mitchell K. P. et al. (Wiley, 2014-10-30)
      Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are characterized by the presence of α-synuclein-containing Lewy bodies and Lewy neurites. However, both dementias also show variable degrees of ...