Now showing items 7-9 of 9

    • Reduction of RPT6/S8 (a Proteasome Component) and Proteasome Activity in the Cortex is Associated with Cognitive Impairment in Lewy Body Dementia. 

      Alghamdi, Amani; Vallortigara, Julie; Howlett, David R; Broadstock, Martin; Hortobágyi, Tibor; Ballard, Clive; Thomas, Alan J et al. (IOS Press, 2017-01)
      Lewy body dementia is the second most common neurodegenerative dementia and is pathologically characterized by $\alpha$-synuclein positive cytoplasmic inclusions, with varying amounts of amyloid-$\beta$ (A$\beta$) and ...
    • Regional Multiple Pathology Scores Are Associated with Cognitive Decline in Lewy Body Dementias 

      Howlett, David R; Whitfield, David; Johnson, Mary; Attems, Johannes; O’Brien, John T; Aarsland, Dag; Lai, Mitchell KP et al. (Wiley, 2014-10-30)
      Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) are characterized by the presence of α-synuclein-containing Lewy bodies and Lewy neurites. However, both dementias also show variable degrees of ...
    • A roadmap to advance dementia research in prevention, diagnosis, intervention, and care by 2025. 

      Pickett, James; Bird, Cathy; Ballard, Clive; Banerjee, Sube; Brayne, Carol Elspeth; Cowan, Katherine; Clare, Linda et al. (Wiley-Blackwell, 2018-07)
      Objective: National and global dementia plans have focused on the research ambition to develop a cure or disease-modifying therapy by 2025, with the initial focus on investment in drug discovery approaches. We set out to ...