Now showing items 70-89 of 92

    • Self-referential and social cognition in a case of autism and agenesis of the corpus callosum 

      Lombardo, Michael Vincent; Chakrabarti, Bhismadev; Lai, Meng-Chuan; MRC, AIMS Consortium; Baron-Cohen, Simon (2012-11-21)
      Abstract Background While models of autism spectrum conditions (ASC) are emerging at the genetic level of analysis, clear models at higher levels of analysis, such as neuroanatomy, are lacking. Here we examine agenesis of ...
    • Self-referential cognition and empathy in autism 

      Lombardo, Michael Vincent; Barnes, Jennifer L; Wheelwright, Sally J; Baron-Cohen, Simon (PLoS One, 2007)
      Background. Individuals with autism spectrum conditions (ASC) have profound impairments in the interpersonal social domain, but it is unclear if individuals with ASC also have impairments in the intrapersonal self-referential ...
    • Semi-Metric Topology of the Human Connectome: Sensitivity and Specificity to Autism and Major Depressive Disorder 

      Simas, Tiago; Chattopadhyay, Shayanti; Hagan, Cindy; Kundu, Prantik; Patel, Ameera; Rosemary, Holt; Floris, Dorothea et al. (PLOS, 2015-08-26)
      Introduction: The human functional connectome is a graphical representation, consisting of nodes connected by edges, of the inter-relationships of blood oxygenation-level dependent (BOLD) time-series measured by MRI from ...
    • Sensory reactivity, empathizing and systemizing in autism spectrum conditions and sensory processing disorder. 

      Tavassoli, Teresa; Miller, Lucy Jane; Schoen, Sarah A; Jo Brout, Jennifer; Sullivan, Jillian; Baron-Cohen, Simon (2018-01)
    • Sex and STEM occupation predict Autism-Spectrum Quotient (AQ) scores in half a million people 

      Ruzich, Emily; Allison, Catherine; Chakrabarti, Bhismadev; Smith, Paula; Musto, Henry; Ring, Howard Anton; Baron-Cohen, Simon (PLoS, 2015-10-21)
      This study assesses Autism-Spectrum Quotient (AQ) scores in a ‘big data’ sample collected through the UK Channel 4 television website, following the broadcasting of a medical education program. We examine correlations ...
    • Sex differences in frontal lobe connectivity in adults with autism spectrum conditions 

      Baron-Cohen, Simon (Nature Publishing Group, 2017-04-11)
      Autism spectrum conditions (ASC) are more prevalent in males than females. The biological basis of this difference remains unclear. It has been postulated that one of the primary causes of ASC is a partial disconnection ...
    • Sex/Gender Differences and Autism: Setting the Scene for Future Research 

      Lai, Meng-Chuan; Lombardo, Michael V; Auyeung, Bonnie; Chakrabarti, Bhismadev; Baron-Cohen, Simon (Elsevier, 2014-10-16)
      Objective: The relationship between sex/gender differences and autism has attracted a variety of research ranging from clinical and neurobiological to etiological, stimulated by the male bias in autism prevalence. Findings are ...
    • Spatial localisation in autism: evidence for differences in early cortical visual processing 

      Latham, Keziah; Chung, Susana TL; Allen, Peter M; Tavassoli, Teresa; Baron-Cohen, Simon (2013-02-19)
      Abstract Background Vision in people with autism spectrum conditions (ASC) is reported to be different from people without ASC, but the neural level at which the differences begin to occur is not yet known. Here we examine ...
    • Structural Covariance Networks in Children with Autism or ADHD 

      Bethlehem, Richard; Romero-Garcia, R; Mak, E; Bullmore, Edward Thomas; Baron-Cohen, Simon (Oxford University Press, 2017-06-13)
      While autism and attention-deficit/hyperactivity disorder (ADHD) are considered distinct conditions from a diagnostic perspective, clinically they share some phenotypic features and have high comorbidity. Regardless, most ...
    • Subgrouping siblings of people with autism: identifying the broader autism phenotype 

      Ruzich, Emily; Allison, Catherine; Smith, Paula; Watson, Peter; Auyeung, Bonnie; Ring, Howard Anton; Baron-Cohen, Simon (Wiley, 2015-09-02)
      We investigate the broader autism phenotype (BAP) in siblings of individuals with autism spectrum conditions (ASC). Autistic traits were measured in typical controls (n = 2,000), siblings (n = 496), and volunteers with ASC ...
    • Synaptic and transcriptionally downregulated genes are associated with cortical thickness differences in autism. 

      Romero-Garcia, Rafael; Warrier, Varun; Bullmore, Edward Thomas; Baron-Cohen, Simon; Bethlehem, Richard (Springer Nature, 2018-02-26)
      Differences in cortical morphology - in particular, cortical volume, thickness and surface area - have been reported in individuals with autism. However, it is unclear what aspects of genetic and transcriptomic variation ...
    • Task-related functional connectivity in autism spectrum conditions: an EEG study using wavelet transform coherence 

      Catarino, Ana; Andrade, Alexandre; Churches, Owen; Wagner, Adam Peter; Baron-Cohen, Simon; Ring, Howard Anton (2013-01-12)
      Abstract Background Autism Spectrum Conditions (ASC) are a set of pervasive neurodevelopmental conditions characterized by a wide range of lifelong signs and symptoms. Recent explanatory models of autism propose abnormal ...
    • Testing the ‘extreme female brain’ theory of psychosis in adults with autism spectrum disorder with or without co-morbid psychosis 

      Larson, Felicity V; Lai, Meng-Chuan; Wagner, Adam Peter; MRC, AIMS Consortium; Baron-Cohen, Simon; Holland, Anthony John (PLOS, 2015-06-12)
      Introduction: Males and females in the general population differ, on average, in their drive for empathizing (higher in females) and systemizing (higher in males). People with autism spectrum disorder (ASD) show a drive ...
    • The EU-AIMS Longitudinal European Autism Project (LEAP): clinical characterisation 

      Charman, Tony; Loth, Eva; Tillmann, Julian; Crawley, Daisy; Wooldridge, Caroline; Goyard, David; Ahmad, Jumana et al. (2017-06-23)
      Abstract Background The EU-AIMS Longitudinal European Autism Project (LEAP) is to date the largest multi-centre, multi-disciplinary observational study on biomarkers for autism ...
    • The EU-AIMS Longitudinal European Autism Project (LEAP): design and methodologies to identify and validate stratification biomarkers for autism spectrum disorders 

      Loth, Eva; Charman, Tony; Mason, Luke; Tillmann, Julian; Jones, Emily J H; Wooldridge, Caroline; Ahmad, Jumana et al. (2017-06-23)
      Abstract Background The tremendous clinical and aetiological diversity among individuals with autism spectrum disorder (ASD) has been a major obstacle to the development of ...
    • Typical magnitude and spatial extent of crowding in autism 

      Freyberg, Jan; Robertson, Caroline E; Baron-Cohen, Simon (Association for Research in Vision and Ophthalmology, 2016-03-21)
      Enhanced spatial processing of local visual details has been reported in individuals with autism spectrum conditions (ASC), and crowding is postulated to be a mechanism that may produce this ability. However, evidence for ...
    • Unsupervised data-driven stratification of mentalizing heterogeneity in autism 

      Lombardo, Michael V; Lai, Meng-Chuan; Auyeung, Bonnie; Holt, Rosemary J; Allison, Catherine; Smith, Paula; Chakrabarti, Bhismadev et al. (2016-10-18)
    • Unsupervised data-driven stratification of mentalizing heterogeneity in autism 

      Lombardo, Michael V; Lai, Meng-Chuan; Auyeung, Bonnie; Holt, Rosemary Jane; Allison, Catherine; Smith, Paula; Chakrabarti, Bhismadev et al. (Nature Publishing Group, 2016-10-18)
      Individuals affected by autism spectrum conditions (ASC) are considerably heterogeneous. Novel approaches are needed to parse this heterogeneity to enhance precision in clinical and translational research. Applying a ...
    • Validation of existing diagnosis of autism in mainland China using standardised diagnositc instruments 

      Sun, Xiang; Allison, Catherine; Auyeung, Bonnie; Zhixiang, Zhang; Matthews, Fiona E; Baron-Cohen, Simon; Brayne, Carol Elspeth (SAGE, 2015-03-10)
      Research to date in mainland China has mainly focused on children with autistic disorder rather than Autism Spectrum Conditions and the diagnosis largely depended on clinical judgment without the use of diagnostic instruments. ...
    • Validation of the Empathy Quotient in Mainland China. 

      Zhao, Q; Neumann, DL; Cao, X; Baron-Cohen, Simon; Sun, X; Cao, Y; Yan, C et al. (Taylor and Francis, 2017-05-24)
      This research aimed to validate a simplified Chinese version of the Empathy Quotient (EQ; 60 items) for use with Mainland Chinese people. The original English version of the EQ was translated into simplified Chinese. Through ...