Now showing items 1-19 of 19

    • Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study 

      Zheng, Ju-Sheng; Sharp, Stephen J; Imamura, Fumiaki; Koulman, Albert; Schulze, Matthias B; Ye, Zheng; Griffin, Jules et al. (2017-11-17)
      Abstract Background Accumulating evidence suggests that individual circulating saturated fatty acids (SFAs) are heterogeneous in their associations with cardio-metabolic ...
    • The association of education with body mass index and waist circumference in the EPIC-PANACEA study 

      Hermann, Silke; Rohrmann, Sabine; Linseisen, Jakob; May, Anne M; Kunst, Anton; Besson, Herve; Romaguera, Dora et al. (2011-03-17)
      Abstract Background To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Method This study included ...
    • The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes - the EPIC-InterAct Study 

      Podmore, Clara; Meidtner, Karina; Schulze, Matthias B; Scott, Robert; Ramond, Anna; Butterworth, Adam Stuart; di, Angelantonio Emanuele et al. (American Diabetes Association, 2016-02-09)
      Objective: Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores for T2D development. However, ferritin is influenced by factors other than iron stores, ...
    • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents 

      di, Angelantonio Emanuele; Bhupathiraju, Shilpa N; Wormser, David; Gao, Pei; Kaptoge, Stephen Kipkemoi; Berrington, de Gonzalez Amy; Cairns, Benjamin J et al. (Elsevier, 2016-07-13)
      Background: Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant-data meta-analyses of the prospective studies of body ...
    • Circulating copper and zinc levels and risk of hepatobiliary cancers in Europeans. 

      Stepien, Magdalena; Hughes, David J; Hybsier, Sandra; Bamia, Christina; Tjønneland, Anne; Overvad, Kim; Affret, Aurélie et al. (2017-02-02)
      BACKGROUND: Copper and zinc are essential micronutrients and cofactors of many enzymatic reactions that may be involved in liver-cancer development. We aimed to assess pre-diagnostic circulating levels of copper, zinc and ...
    • Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity 

      Scott, Robert; Fall, Tove; Pasko, Dorota; Barker, Adam; Sharp, Stephen John; Arriola, Larraitz; Balkau, Beverley et al. (American Diabetes Association, 2014-06-19)
      We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, ...
    • Determinants of non- response to a second assessment of lifestyle factors and body weight in the EPIC-PANACEA study 

      May, Anne M; Adema, Lotte E; Romaguera, Dora; Vergnaud, Anne-Claire; Agudo, Antonio; Ekelund, Ulf Mikael; Steffen, Annika et al. (2012-09-24)
      Abstract Background This paper discusses whether baseline demographic, socio-economic, health variables, length of follow-up and method of contacting the participants predict non-response to the invitation for a second ...
    • Diet Quality Scores and Prediction of All-Cause, Cardiovascular and Cancer Mortality in a Pan-European Cohort Study 

      Lassale, Camille; Gunter, Marc J; Romaguera, Dora; Peelen, Linda M; Van, der Schouw Yvonne T; Beulens, Joline WJ; Freisling, Heinz et al. (Public Library of Science, 2016-07-13)
      Scores of overall diet quality have received increasing attention in relation to disease aetiology; however, their value in risk prediction has been little examined. The objective was to assess and compare the association ...
    • Flavonoid and lignan intake and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort 

      Molina-Montes, Esther; Sánchez, María-José; Zamora-Ros, Raul; Bueno-de-Mesquita, HB(as); Wark, Petra A; Obon-Santacana, Mireia; Kühn, Tilman et al. (Wiley, 2016)
      Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between ...
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert; Freitag, Daniel F; Li, Li; Chu, Audrey Y; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (American Association for the Advancement of Science, 2016-06-01)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study 

      Vineis, Paolo; Hoek, Gerard; Krzyzanowski, Michal; Vigna-Taglianti, Federica; Veglia, Fabrizio; Airoldi, Luisa; Overvad, Kim et al. (2007-02-15)
      Abstract Background Several countries are discussing new legislation on the ban of smoking in public places, and on the acceptable levels of traffic-related air pollutants. It is therefore useful to estimate the burden of ...
    • Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition 

      Rohrmann, Sabine; Overvad, Kim; Bueno-de-Mesquita, HB; Jakobsen, Marianne U; Egeberg, Rikke; Tjønneland, Anne; Nailler, Laura et al. (2013-03-07)
      Abstract Background Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study ...
    • Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study 

      Romaguera, Dora; Ward, Heather; Wark, Petra A; Vergnaud, Anne-Claire; Peeters, Petra H; van, Gils Carla H; Ferrari, Pietro et al. (2015-05-07)
      Abstract Background Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research ...
    • Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition 

      Ward, Heather A; Norat, Teresa; Overvad, Kim; Dahm, Christina C; Bueno-de-Mesquita, H Bas; Jenab, Mazda; Fedirko, Veronika et al. (2016-05-19)
      Improvements in colorectal cancer (CRC) detection and treatment have led to greater numbers of CRC survivors, for whom there is limited evidence on which to provide dietary guidelines to improve survival outcomes. Higher ...
    • Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition 

      Ward, Heather A; Norat, Teresa; Overvad, Kim; Dahm, Christina C; Bueno-de-Mesquita, H Bas; Jenab, Mazda; Fedirko, Veronika et al. (Cambridge University Press, 2016-05-19)
      Improvements in colorectal cancer (CRC) detection and treatment have led to greater numbers of CRC survivors, for whom there is limited evidence on which to provide dietary guidelines to improve survival outcomes. Higher ...
    • Pre-diagnostic metabolite concentrations and prostate cancer risk in 1077 cases and 1077 matched controls in the European Prospective Investigation into Cancer and Nutrition 

      Schmidt, Julie A; Fensom, Georgina K; Rinaldi, Sabina; Scalbert, Augustin; Appleby, Paul N; Achaintre, David; Gicquiau, Audrey et al. (2017-07-05)
      Abstract Background Little is known about how pre-diagnostic metabolites in blood relate to risk of prostate cancer. We aimed to investigate the prospective association between ...
    • Reproductive factors and risk of mortality in the European Prospective Investigation into Cancer and Nutrition; a cohort study 

      Merritt, Melissa A; Riboli, Elio; Murphy, Neil; Kadi, Mai; Tjønneland, Anne; Olsen, Anja; Overvad, Kim et al. (2015-10-30)
      Abstract Background Reproductive events are associated with important physiologic changes, yet little is known about how reproductive factors influence long-term health in ...
    • Serum Endotoxins and Flagellin and Risk of Colorectal Cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) Cohort. 

      Kong, So Yeon; Tran, Hao Quang; Gewirtz, Andrew T; McKeown-Eyssen, Gail; Fedirko, Veronika; Romieu, Isabelle; Tjønneland, Anne et al. (2016-02)
      BACKGROUND: Chronic inflammation and oxidative stress are thought to be involved in colorectal cancer development. These processes may contribute to leakage of bacterial products, such as lipopolysaccharide (LPS) and ...
    • Tall height and obesity are associated with an increased risk of aggressive prostate cancer: results from the EPIC cohort study 

      Perez-Cornago, Aurora; Appleby, Paul N; Pischon, Tobias; Tsilidis, Konstantinos K; Tjønneland, Anne; Olsen, Anja; Overvad, Kim et al. (2017-07-13)
      Abstract Background The relationship between body size and prostate cancer risk, and in particular risk by tumour characteristics, is not clear because most studies have not ...