Now showing items 1-10 of 10

    • The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes - the EPIC-InterAct Study 

      Podmore, Clara; Meidtner, Karina; Schulze, Matthias B.; Scott, Robert A.; Ramond, Anna; Butterworth, Adam S.; di Angelantonio, Emanuele et al. (American Diabetes Association, 2016-02-09)
      Objective: Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores for T2D development. However, ferritin is influenced by factors other than iron stores, ...
    • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents 

      di Angelantonio, Emanuele; Bhupathiraju, Shilpa N.; Wormser, David; Gao, Pei; Kaptoge, Stephen; Berrington de Gonzalez, Amy; Cairns, Benjamin J. et al. (Elsevier, 2016-07-13)
      Background: Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant-data meta-analyses of the prospective studies of body ...
    • Common genetic variants highlight the role of insulin resistance and body fat distribution in type 2 diabetes, independently of obesity 

      Scott, Robert A.; Fall, Tove; Pasko, Dorota; Barker, Adam; Sharp, Stephen J.; Arriola, Larraitz; Balkau, Beverley et al. (American Diabetes Association, 2014-06-19)
      We aimed to validate genetic variants as instruments for insulin resistance and secretion, to characterise their association with intermediate phenotypes, and to investigate their role in T2D risk among normal-weight, ...
    • Determinants of non- response to a second assessment of lifestyle factors and body weight in the EPIC-PANACEA study 

      May, Anne M.; Adema, Lotte E.; Romaguera, Dora; Vergnaud, Anne-Claire; Agudo, Antonio; Ekelund, Ulf; Steffen, Annika et al. (2012-09-24)
      Abstract Background This paper discusses whether baseline demographic, socio-economic, health variables, length of follow-up and method of contacting the participants predict non-response to the invitation for a second ...
    • Flavonoid and lignan intake and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort 

      Molina-Montes, Esther; Sánchez, María-José; Zamora-Ros, Raul; Bueno-de-Mesquita, H.B(as).; Wark, Petra A.; Obon-Santacana, Mireia; Kühn, Tilman et al. (Wiley, 2016)
      Despite the potential cancer preventive effects of flavonoids and lignans, their ability to reduce pancreatic cancer risk has not been demonstrated in epidemiological studies. Our aim was to examine the association between ...
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert A.; Freitag, Daniel F.; Li, Li; Chu, Audrey Y.; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (American Association for the Advancement of Science, 2016-06-01)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Lung cancers attributable to environmental tobacco smoke and air pollution in non-smokers in different European countries: a prospective study 

      Vineis, Paolo; Hoek, Gerard; Krzyzanowski, Michal; Vigna-Taglianti, Federica; Veglia, Fabrizio; Airoldi, Luisa; Overvad, Kim et al. (2007-02-15)
      Abstract Background Several countries are discussing new legislation on the ban of smoking in public places, and on the acceptable levels of traffic-related air pollutants. It is therefore useful to estimate the burden of ...
    • Meat consumption and mortality - results from the European Prospective Investigation into Cancer and Nutrition 

      Rohrmann, Sabine; Overvad, Kim; Bueno-de-Mesquita, H. B.; Jakobsen, Marianne U.; Egeberg, Rikke; Tjønneland, Anne; Nailler, Laura et al. (2013-03-07)
      Abstract Background Recently, some US cohorts have shown a moderate association between red and processed meat consumption and mortality supporting the results of previous studies among vegetarians. The aim of this study ...
    • Pre-diagnostic meat and fibre intakes in relation to colorectal cancer survival in the European Prospective Investigation into Cancer and Nutrition 

      Ward, Heather A.; Norat, Teresa; Overvad, Kim; Dahm, Christina C.; Bueno-de-Mesquita, H. Bas; Jenab, Mazda; Fedirko, Veronika et al. (Cambridge University Press, 2016-05-19)
      Improvements in colorectal cancer (CRC) detection and treatment have led to greater numbers of CRC survivors, for whom there is limited evidence on which to provide dietary guidelines to improve survival outcomes. Higher ...
    • The association of education with body mass index and waist circumference in the EPIC-PANACEA study 

      Hermann, Silke; Rohrmann, Sabine; Linseisen, Jakob; May, Anne M.; Kunst, Anton; Besson, Herve; Romaguera, Dora et al. (2011-03-17)
      Abstract Background To examine the association of education with body mass index (BMI) and waist circumference (WC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Method This study included ...