Now showing items 1-12 of 12

    • A Kallikrein 15 (KLK15) single nucleotide polymorphism located close to a novel exon shows evidence of association with poor ovarian cancer survival 

      Batra, Jyotsna; Nagle, Christina M.; O'Mara, Tracy; Higgins, Melanie; Dong, Ying; Tan, Olivia L.; Lose, Felicity et al. (2011-04-01)
      Abstract Background KLK15 over-expression is reported to be a significant predictor of reduced progression-free survival and overall survival in ovarian cancer. Our aim was to analyse the KLK15 gene for putative functional ...
    • Alcohol consumption and prostate cancer incidence and progression: A Mendelian randomisation study 

      Brunner, Clair; Davies, Neil M.; Martin, Richard M.; Eeles, Rosalind; Easton, Doug; Kote-Jarai, Zsofia; Amin Al Olama, Ali et al. (Wiley, 2016-09-19)
      Prostate cancer is the most common cancer in men in developed countries, and is a target for risk reduction strategies. The effects of alcohol consumption on prostate cancer incidence and survival remain unclear, potentially ...
    • Assessing the role of insulin-like growth factors and binding proteins in prostate cancer using Mendelian randomization: genetic variants as instruments for circulating levels 

      Bonilla, Carolina; Lewis, Sarah J.; Rowlands, Mari-Anne; Gaunt, Tom R.; Smith, George Davey; Gunnell, David; Palmer, Tom et al. (Wiley, 2016)
      Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are ...
    • Atlas of prostate cancer heritability in European and African-American men pinpoints tissue-specific regulation 

      Gusev, Alexander; Shi, Huwenbo; Kichaev, Gleb; Pomerantz, Mark; Li, Fugen; Long, Henry W.; Ingles, Sue A. et al. (Nature Publishing Group, 2016-04-07)
      Although genome-wide association studies have identified over 100 risk loci that explain ~33% of familial risk for prostate cancer (PrCa), their functional effects on risk remain largely unknown. Here we use genotype data ...
    • Blood lipids and prostate cancer: a Mendelian randomization analysis 

      Bull, Caroline J.; Bonilla, Carolina; Holly, Jeff M. P.; Perks, Claire M.; Davies, Neil; Haycock, Philip; Yu, Oriana Hoi Yun et al. (Wiley, 2016-03-19)
      Genetic risk scores were used as unconfounded instruments for specific lipid traits (Mendelian randomization) to assess whether circulating lipids causally influence prostate cancer risk. Data from 22,249 prostate cancer ...
    • Fine-mapping of the HNF1B multicancer locus identifies candidate variants that mediate endometrial cancer risk 

      Painter, Jodie N.; O’Mara, Tracy A.; Batra, Jyotsna; Cheng, Timothy; Lose, Felicity A.; Dennis, Joe; Michailidou, Kyriaki et al. (Oxford Journals, 2014-11-06)
      Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with the risk of type II diabetes and multiple cancers. Evidence to date indicates that cancer risk may be mediated via genetic or ...
    • Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array 

      Saunders, Edward J.; Dadaev, Tokhir; Leongamornlert, Daniel A.; Al Olama, Ali Amin; Benlloch, Sara; Giles, Graham G.; Wiklund, Fredrik et al. (Nature Publishing Group, 2016-03-10)
      Background: Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, ...
    • Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types 

      Kar, Siddhartha P.; Beesley, Jonathan; Amin Al Olama, Ali; Michailidou, Kyriaki; Tyrer, Jonathan; Kote-Jarai, ZSofia; Lawrenson, Kate et al. (American Association for Cancer Research, 2016-07-17)
      Breast, ovarian, and prostate cancers are hormone-related and may have a shared genetic basis, but this has not been investigated systematically by genome-wide association (GWA) studies. Meta-analyses combining the largest ...
    • Investigating the possible causal role of coffee consumption with prostate cancer risk and progression using Mendelian randomization analysis 

      Taylor, Amy E.; Martin, Richard M.; Geybels, Milan S.; Stanford, Janet L.; Shui, Irene; Eeles, Rosalind; Easton, Doug et al. (Wiley, 2016-10-26)
      Coffee consumption has been shown in some studies to be associated with lower risk of prostate cancer. However, it is unclear if this association is causal or due to confounding or reverse causality. We conducted a Mendelian ...
    • PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS 

      Southey, Melissa C.; Goldgar, David; Winqvist, Robert; Pylkäs, Katri; Couch, Fergus; Tischkowitz, Marc; Foulkes, William et al. (BMJ Publishing Group, 2016-09-05)
      Background The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are ...
    • Pubertal development and prostate cancer risk: Mendelian randomization study in a population-based cohort 

      Bonilla, Carolina; Lewis, Sarah J.; Martin, Richard M.; Donovan, Jenny L.; Hamdy, Freddie C.; Neal, David E.; Eeles, Rosalind et al. (BioMed Central, 2016-04-04)
      Background: Epidemiological studies have observed a positive association between an earlier age at sexual development and prostate cancer, but markers of sexual maturation in boys are imprecise and observational estimates ...
    • Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci 

      Amin Al Olama, Ali; Benlloch, Sara; Antoniou, Antonis C.; Giles, Graham G.; Severi, Gianluca; Neal, David; Hamdy, Freddie C. et al. (AACR, 2015-04-02)
      BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer (PrCa) risk which explain a substantial proportion of familial relative risk. These variants can be used ...