Now showing items 12-31 of 53

• #### The Cambridge Centre for Ageing and Neuroscience (Cam-CAN) study protocol: a cross-sectional, lifespan, multidisciplinary examination of healthy cognitive ageing ﻿

(BioMed Central, 2014-10-14)
Background As greater numbers of us are living longer, it is increasingly important to understand how we can age healthily. Although old age is often stereotyped as a time of declining mental abilities and inflexibility, ...
• #### Changing non-participation in epidemiological studies of older people: evidence from the Cognitive Function and Ageing Study I and II ﻿

(OUP, 2015-08-14)
Background: non-participation in epidemiological studies threatens the generalisability of findings. Objective: to investigate the change in non-participation between the Medical Research Council Cognitive Function and ...
• #### Cognitive function in a general population of men and women: A cross sectional study in the European Investigation of Cancer–Norfolk cohort (EPIC-Norfolk) ﻿

(BioMed Central, 2014-12-19)
Background: Although ageing is strongly associated with cognitive decline, a wide range of cognitive ability is observed in older populations with varying rates of change across different cognitive domains. Objective: We ...
• #### Cohort differences in disease and disability in the young-old: findings from the MRC Cognitive Function and Ageing Study (MRC-CFAS) ﻿

(2007-07-13)
Abstract Background Projections of health and social care need are highly sensitive to assumptions about cohort trends in health and disability. We use a repeated population-based cross-sectional study from the Cambridgeshire ...
• #### Community environment, cognitive impairment and dementia in later life: results from the Cognitive Function and Ageing Study ﻿

(Oxford University Press, 2015-10-13)
Background: Few studies have investigated the impact of the community environment, as distinct from area deprivation, on cognition in later life. This study explores cross-sectional associations between cognitive impairment ...
• #### Daytime napping and increased risk of incident respiratory diseases: symptom, marker, or risk factor? ﻿

(Elsevier, 2016-07-12)
$\textit{Background:}$ We have identified a strong association between daytime napping and increased mortality risk from respiratory diseases, but little is known about the relationship between daytime napping and respiratory ...
• #### Daytime napping, sleep duration and serum C-reactive protein: a population-based cohort study ﻿

(BMJ Group, 2014-11-11)
Objectives: To explore whether daytime napping and sleep duration are linked to serum C-reactive protein (CRP), a pro-inflammatory marker, in an older-aged British population. Design: Cross-sectional study Setting: ...
• #### Death and the Oldest Old: Attitudes and Preferences for End-of-Life Care Qualitative Research within a Population-Based Cohort Study ﻿

(Public Library Of Science, 2016)
Introduction: Increasing longevity means more people will be dying in very old age, but little is known about the preferences of the ‘oldest old’ regarding their care at the end of life. Aims: To understand very old ...
• #### Dementia in western Europe: epidemiological evidence and implications for policy making ﻿

(Elsevier, 2015-06-10)
Dementia impact has received increasing attention of governments and politicians across the globe in recent years. Epidemiological research based Western European populations twenty years ago provided key evidence for ...
• #### Dementia Priority Setting Partnership with the James Lind Alliance: Using patient and public involvement and the evidence base to inform the research agenda ﻿

(Oxford Journals, 2015)
Background: the James Lind Alliance (JLA) created an approach to elicit the views of those under-represented in research priority exercises. Building on this, the JLA Dementia Priority Setting Partnership was set up as an ...
• #### Dementia: time trends and policy responses ﻿

(Elsevier, 2014-07-08)
In recent years, dementia has been considered a public health priority and become a topic of major political interest. Recent reviews and studies have reported with varying degrees of alarm an impending and existing “dementia ...
• #### Examining the influence of gender, education, social class and birth cohort on MMSE tracking over time: a population-based prospective cohort study ﻿

(2012-08-13)
Abstract Background Whilst many studies have analysed predictors of longitudinal cognitive decline, few have described their impact on population distributions of cognition by age cohort. The aim of this paper was to examine ...
• #### Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study ﻿

(2008-03-17)
Abstract Background The "oldest old" are now the fastest growing section of most western populations, yet there are scarcely any data concerning even the common problem of falls amongst the very old. Prospective data ...
• #### The impact of delirium on cognitive outcomes in population-based studies ﻿

(2014-07-01)
Acute hospitals have seen unprecedented demographic changes, where older age, frailty and cognitive impairment now characterise the majority of health service users. Delirium is very common in this setting, and adverse ...
• #### Land use mix and five-year mortality in later life: results from the Cognitive Function and Ageing Study ﻿

(Elsevier, 2016-02-01)
This study explores the potential modifying effect of age and mediation effect of co-morbidity on the association between land use mix, a measure of neighbourhood walkability, and five-year mortality among the 2424 individuals ...
• #### Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study ﻿

(2009-06-15)
Abstract Background Functional disability, the loss of ability to carry out daily tasks unaided, is a major adverse outcome more common with increasing age. The potential contribution of neuropathological changes in ...
• #### Montreal Cognitive Assessment for the diagnosis of Alzheimer’s disease and other dementias ﻿

(Wiley, 2015-10-29)
Background: Dementia is a progressive syndrome of global cognitive impairment with significant health and social care costs. Global prevalence is projected to increase, particularly in resource-limited settings. Recent ...
• #### A multimodal approach to dementia prevention: A report from the Cambridge Institute of Public Health ﻿

(Elsevier, 2015-10-01)
Background: Globally, dementia is the most frequent form of degenerative condition in the older adult population and poses a major health burden with high socioeconomic costs (1). So far, attempts to find pharmacological ...
• #### Nutrition and the Prevalence of Dementia in Mainland China, Hong Kong, and Taiwan: An Ecological Study ﻿

(IOS Press, 2014-11-07)
Background:Western diets are associated with obesity, vascular diseases, and metabolic syndrome and might increase dementia risk in later life. If these associations are causal, those low- and middle-income countries ...
• #### Obesity associated with increased brain age from midlife ﻿

(Elsevier, 2016-07-27)
Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however, direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis ...