Now showing items 29-48 of 62

• #### Falls in advanced old age: recalled falls and prospective follow-up of over-90-year-olds in the Cambridge City over-75s Cohort study ﻿

(2008-03-17)
Abstract Background The "oldest old" are now the fastest growing section of most western populations, yet there are scarcely any data concerning even the common problem of falls amongst the very old. Prospective data ...
• #### ICC-dementia (International Centenarian Consortium - dementia): an international consortium to determine the prevalence and incidence of dementia in centenarians across diverse ethnoracial and sociocultural groups ﻿

(2016-04-21)
Abstract Background Considerable variability exists in international prevalence and incidence estimates of dementia. The accuracy of estimates of dementia in the oldest-old ...
• #### Is Dementia Screening of Apparently Healthy Individuals Justified? ﻿

(2017-8-8)
Despite efforts to raise awareness and develop guidelines for care of individuals with dementia, reports of poor detection and inadequate management persist. This has led to a call for more identification of people with ...
• #### Land use mix and five-year mortality in later life: results from the Cognitive Function and Ageing Study ﻿

(Elsevier, 2016-02-01)
This study explores the potential modifying effect of age and mediation effect of co-morbidity on the association between land use mix, a measure of neighbourhood walkability, and five-year mortality among the 2424 individuals ...
• #### Lewy bodies and neuronal loss in subcortical areas and disability in non-demented older people: a population based neuropathological cohort study ﻿

(2009-06-15)
Abstract Background Functional disability, the loss of ability to carry out daily tasks unaided, is a major adverse outcome more common with increasing age. The potential contribution of neuropathological changes in ...
• #### Montreal Cognitive Assessment for the diagnosis of Alzheimer’s disease and other dementias ﻿

(Wiley, 2015-10-29)
$\textbf{Background:}$ Dementia is a progressive syndrome of global cognitive impairment with significant health and social care costs. Global prevalence is projected to increase, particularly in resource-limited settings. ...
• #### A multimodal approach to dementia prevention: A report from the Cambridge Institute of Public Health ﻿

(Elsevier, 2015-10-01)
$\textbf{Introduction:}$ Globally, dementia is the most frequent form of degenerative condition in the older adult population and poses a major health burden with high socioeconomic costs. So far, attempts to find pharmacologic ...
• #### Nutrition and the Prevalence of Dementia in Mainland China, Hong Kong, and Taiwan: An Ecological Study ﻿

(IOS Press, 2014-11-07)
$\textbf{Background:}$ Western diets are associated with obesity, vascular diseases, and metabolic syndrome and might increase dementia risk in later life. If these associations are causal, those low- and middle-income ...
• #### Obesity associated with increased brain age from midlife ﻿

(Elsevier, 2016-07-27)
Common mechanisms in aging and obesity are hypothesized to increase susceptibility to neurodegeneration, however, direct evidence in support of this hypothesis is lacking. We therefore performed a cross-sectional analysis ...
• #### Older people, the natural environment and common mental disorders: cross-sectional results from the Cognitive Function and Ageing Study ﻿

(BMJ, 2015-09-16)
$\textbf{Objectives:}$ To explore the hypothesis that higher exposure to natural environments in local areas is associated with a lower odds of depression and anxiety in later life. $\textbf{Design:}$ A cross-sectional ...
• #### Patterns and persistence of behavioural and psychological symptoms in those with cognitive impairment: the importance of apathy ﻿

(Wiley, 2016-03-27)
Objective To study the stability and emergence of a range of behavioural and psychological symptoms (BPS), their association with mortality and the effect of covariates on these transitions in a population-based study ...
• #### Period, birth cohort and prevalence of dementia in mainland China, Hong Kong and Taiwan: a meta-analysis ﻿

(Wiley, 2014-05-22)
$\textbf{Objective:}$ There have been dramatic societal changes in East Asia over the last hundred years. Several of the established risk factors could have important period and cohort effects. This study explores temporal ...
• #### Population studies of sporadic cerebral amyloid angiopathy and dementia: a systematic review ﻿

(2009-01-13)
Abstract Background Deposition of amyloid-β (Aβ) in vessel walls of the brain as cerebral amyloid angiopathy (CAA) could be a major factor in the pathogenesis of dementia. Here we investigate the relationship between ...
• #### Population-based neuropathological studies of dementia: design, methods and areas of investigation - a systematic review ﻿

(2006-01-09)
Abstract Background Prospective population-based neuropathological studies have a special place in dementia research which is under emphasised. Methods A systematic review of the methods of population-based neuropathological ...
• #### Prevalence of autism in mainland China, Hong Kong and Taiwan: a systematic review and meta-analysis ﻿

(2013-04-09)
Abstract Background The prevalence of autism spectrum conditions (ASC) is 1% in developed countries, but little data are available from mainland China, Hong Kong and Taiwan. This study synthesizes evidence relating to the ...
• #### Prevalence of dementia in East Asia: a synthetic review of time trends ﻿

(Wiley, 2015-05-11)
$\textbf{Objective:}$ This study aims to synthesise evidence on time trends of dementia prevalence in East Asian countries including Japan, China, South Korea and Taiwan and assess the impact of the societal changes on ...
• #### Prevalence Studies of Dementia in Mainland China, Hong Kong and Taiwan: A Systematic Review and Meta-Analysis ﻿

(PLOS, 2013-06-11)
$\textbf{Background:}$ Many studies have considered the prevalence of dementia in mainland China, Hong Kong and Taiwan. However, area level estimates have not been produced. This study examines area differences across ...
• #### Prevalence, characteristics, and survival of frontotemporal lobar degeneration syndromes ﻿

(Wolters Kluwer, 2016-04-01)
$\textbf{Objectives:}$ To estimate the lifetime risk, prevalence, incidence, and mortality of the principal clinical syndromes associated with frontotemporal lobar degeneration (FTLD) using revised diagnostic criteria and ...
• #### Protocol for the Delirium and Cognitive Impact in Dementia (DECIDE) study: A nested prospective longitudinal cohort study ﻿

(2017-04-28)
$\textbf{Background}$ Delirium is common, affecting at least 20% of older hospital inpatients. It is widely accepted that delirium is associated with dementia but the degree of causation within this ...
• #### Re-examining tau-immunoreactive pathology in the population: granulovacuolar degeneration and neurofibrillary tangles ﻿

(BioMed Central, 2015-08-28)
$\textbf{Introduction:}$ Alzheimer’s disease (AD) is associated with neurofibrillary pathology, including neurofibrillary tangles (NFT), neuritic plaques (NP) and neuropil threads containing aggregated microtubule associated ...