Browsing by Author "Brenton, James D"
Identification and Development of 2,3-Dihydropyrrolo[1,2-a]quinazolin-5(1H)-one Inhibitors Targeting Bromodomains within the Switch/Sucrose Nonfermenting Complex Sutherell, Charlotte L; Tallant, Cynthia; Monteiro, Octovia P; Yapp, Clarence; Fuchs, Julian E; Fedorov, Oleg; Siejka, PaulinaMüller, SuzanneKnapp, StefanBrenton, James DBrennan, Paul ELey, Steven Victor et al. (2016-04-27)Bromodomain containing proteins PB1, SMARCA4, and SMARCA2 are important components of SWI/SNF chromatin remodeling complexes. We identified bromodomain inhibitors that target these proteins and display unusual binding modes ...
Models of endometriosis and their utility in studying progression to ovarian clear cell carcinoma. King, Claire M; Barbara, Cynthia; Prentice, Andrew; Brenton, James D; Charnock-Jones, David Stephen (2015-12-23)
Structural and calorimetric studies demonstrate that the Hepatocyte Nuclear Factor 1β (HNF1β) transcription factor is imported into the nucleus via a monopartite NLS sequence Wiedmann, Mareike M; Aibara, Shintaro; Spring, David Robert; Stewart, Murray; Brenton, James D (2016-06-21)