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Browsing by Author "Canzian, Federico"
Now showing items 1-6 of 6
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Genetic polymorphisms of the GNRH1 and GNRHR genes and risk of breast cancer in the National Cancer Institute Breast and Prostate Cancer Cohort Consortium (BPC3)
Canzian, Federico; Kaaks, Rudolf; Cox, David G.; Henderson, Katherine D.; Henderson, Brian E.; Berg, Christine; Bingham, SheilaBoeing, HeinerBuring, JulieCalle, Eugenia E.Chanock, Stephen J.Clavel-Chapelon, FrançoiseDossus, LaureSpencer Feigelson, HeatherHaiman, Christopher A.Hankinson, Susan E.Hoover, RobertHunter, David J.Isaacs, ClaudineLenner, PerLund, EilivOvervad, KimPalli, DomenicoPearce, Celeste LeighQuiros, Jose R.Riboli, ElioStram, Daniel O.Thomas, GIllesThun, Michael J.Trichopoulos, Dimitriosvan Gils, Carla H.Ziegler, Regina G. et al. (2009-07-29)Abstract Background Gonadotropin releasing hormone (GNRH1) triggers the release of follicle stimulating hormone and luteinizing hormone from the pituitary. Genetic variants in the gene encoding GNRH1 or its receptor may ... -
Genome-wide association analysis of more than 120,000 individuals identifies 15 new susceptibility loci for breast cancer.
Michailidou, Kyriaki; Beesley, Jonathan; Lindstrom, Sara; Canisius, Sander; Dennis, Joe; Lush, Michael J.; Maranian, Mel J.Bolla, Manjeet K.Wang, QinShah, MitulPerkins, Barbara J.Czene, KamilaEriksson, MikaelDarabi, HatefBrand, Judith S.Bojesen, Stig E.Nordestgaard, Borge G.Flyger, HenrikNielsen, Sune F.Rahman, NazneenTurnbull, ClareBOCSFletcher, OliviaPeto, JulianGibson, Lornados-Santos-Silva, IsabelChang-Claude, JennyFlesch-Janys, DieterRudolph, AnjaEilber, UrsulaBehrens, SabineNevanlinna, HeliMuranen, Taru A.Aittomaki, KristiinaBlomqvist, CarlKhan, SofiaAaltonen, KirsimariAhsan, HabibulKibriya, Muhammad G.Whittemore, Alice S.John, Esther M.Malone, Kathleen E.Gammon, Marilie D.Santella, Regina M.Ursin, GiskeMakalic, EnesSchmidt, Daniel F.Casey, GrahamHunter, David J.Gapstur, Susan M.Gaudet, Mia M.Diver, W. RyanHaiman, Christopher A.Schumacher, FredrickHenderson, Brian E.Le Marchand, LoicBerg, Christine D.Chanock, Stephen J.Figueroa, JonineHoover, Robert N.Lambrechts, DietherNeven, PatrickWildiers, Hansvan Limbergen, ErikSchmidt, Marjanka K.Broeks, AnnegienVerhoef, SennoCornelissen, StenCouch, Fergus J.Olson, Janet E.Hallberg, EmilyVachon, CelineWaisfisz, QuintenMeijers-Heijboer, HanneAdank, Muriel A.van der Luijt, Rob B.Li, JingmeiLiu, JianjunHumphreys, KeithKang, DaeheeChoi, Ji-YeobPark, Sue K.Yoo, Keun-YoungMatsuo, KeitaroIto, HidemiIwata, HirojiTajima, KazuoGuenel, PascalTruong, ThereseMulot, ClaireSanchez, MarieBurwinkel, BarbaraMarme, FrederikSurowy, HaraldSohn, ChristofWu, Anna H.Tseng, Chiu-chenVan Den Berg, DavidStram, Daniel O.Gonzalez-Neira, AnnaBenitez, JavierZamora, M. PilarPerez, Jose Ignacio AriasShu, Xiao-OuLu, WeiGao, Yu-TangCai, HuiCox, AngelaCross, Simon S.Reed, Malcolm W. R.Andrulis, Irene L.Knight, Julia A.Glendon, GordMulligan, Anna MarieSawyer, Elinor J.Tomlinson, IanKerin, Michael J.Miller, NicolakConFab InvestigatorsAOCS GroupLindblom, AnnikaMargolin, SaraTeo, Soo HwangYip, Cheng HarTaib, Nur Aishah MohdTan, Gie-HooiHooning, Maartje J.Hollestelle, AntoinetteMartens, John W. M.Collee, J. MargrietBlot, WilliamSignorello, Lisa B.Cai, QiuyinHopper, John L.Southey, Melissa C.Tsimiklis, HelenApicella, CarmelShen, Chen-YangHsiung, Chia-NiWu, Pei-EiHou, Ming-FengKristensen, Vessela N.Nord, SiljeAlnaes, Grethe I. GrenakerNBCSGiles, Graham G.Milne, Roger L.McLean, CatrionaCanzian, FedericoTrichopoulos, DimitriosPeeters, PetraLund, EilivSund, MalinKhaw, Kay-TeeGunter, Marc J.Palli, DomenicoMortensen, Lotte MaxildDossus, LaureHuerta, Jose-MariaMeindl, AlfonsSchmutzler, Rita K.Sutter, ChristianYang, RongxiMuir, KennethLophatananon, ArtitayaStewart-Brown, SarahSiriwanarangsan, PornthepHartman, MikaelMiao, HuiChia, Kee SengChan, Ching WanFasching, Peter A.Hein, AlexanderBeckmann, Matthias W.Haeberle, LotharBrenner, HermannDieffenbach, Aida KarinaArndt, VolkerStegmaier, ChristaAshworth, AlanOrr, NickSchoemaker, Minouk J.Swerdlow, Anthony J.Brinton, LouiseGarcia-Closas, MontserratZheng, WeiHalverson, Sandra L.Shrubsole, MarthaLong, JirongGoldberg, Mark S.Labreche, FranceDumont, MartineWinqvist, RobertPylkas, KatriJukkola-Vuorinen, ArjaGrip, MerviBrauch, HiltrudHamann, UteBruning, ThomasGENICA NetworkRadice, PaoloPeterlongo, PaoloManoukian, SiranoushBernard, LorisBogdanova, Natalia V.Dork, ThiloMannermaa, ArtoKataja, VesaKosma, Veli-MattiHartikainen, Jaana M.Devilee, PeterTollenaar, Robert A. E. M.Seynaeve, CarolineVan Asperen, Christi J.Jakubowska, AnnaLubinski, JanJaworska, KatarzynaHuzarski, TomaszSangrajrang, SuleepornGaborieau, ValerieBrennan, PaulMcKay, JamesSlager, SusanToland, Amanda E.Ambrosone, Christine B.Yannoukakos, DrakoulisKabisch, MariaTorres, DianaNeuhausen, Susan L.Anton-Culver, HodaLuccarini, CraigBaynes, CarolineAhmed, ShahanaHealey, Catherine S.Tessier, Daniel C.Vincent, DanielBacot, FrancoisPita, GuillermoAlonso, M. RosarioAlvarez, NuriaHerrero, DanielSimard, JacquesPharoah, Paul D. P.Kraft, PeterDunning, Alison M.Chenevix-Trench, GeorgiaHall, PerEaston, Douglas F. et al. (NPG, 2015-03-09)Genome-wide association studies (GWAS) and large-scale replication studies have identified common variants in 79 loci associated with breast cancer, explaining ~14% of the familial risk of the disease. To identify new ... -
Identification of four novel susceptibility loci for estrogen receptor negative breast cancer
Couch, Fergus J.; Kuchenbaecker, Karoline B.; Michailidou, Kyriaki; Mendoza-Fandino, Gustavo A.; Nord, Silje; Lilyquist, Janna; Olswold, CurtisHallberg, EmilyAgata, SimonaAhsan, HabibulAittomäki, KristiinaAmbrosone, ChristineAndrulis, Irene L.Anton-Culver, HodaArndt, VolkerArun, Banu K.Arver, BritaBarile, MonicaBarkardottir, Rosa B.Barrowdale, DanielBeckmann, LarsBeckmann, Matthias W.Benitez, JavierBlank, Stephanie V.Blomqvist, CarlBogdanova, Natalia V.Bojesen, Stig E.Bolla, Manjeet K.Bonanni, BernardoBrauch, HiltrudBrenner, HermannBurwinkel, BarbaraBuys, Saundra S.Caldes, TrinidadCaligo, Maria A.Canzian, FedericoCarpenter, JaneChang-Claude, JennyChanock, Stephen J.Chung, Wendy K.Claes, Kathleen B. M.Cox, AngelaCross, Simon S.Cunningham, Julie M.Czene, KamilaDaly, Mary B.Damiola, FrancescaDarabi, Hatefde la Hoya, MiguelDevilee, PeterDiez, OrlandDing, Yuan C.Dolcetti, RiccardoDomchek, Susan M.Dorfling, Cecilia M.dos-Santos-Silva, IsabelDumont, MartineDunning, Alison M.Eccles, Diana M.Ehrencrona, HansEkici, Arif B.Eliassen, HeatherEllis, SteveFasching, Peter A.Figueroa, JonineFlesch-Janys, DieterFörsti, AstaFostira, FlorentiaFoulkes, William D.Friebel, TaraFriedman, EitanFrost, DebraGabrielson, MarikeGammon, Marilie D.Ganz, Patricia A.Gapstur, Susan M.Garber, JudyGaudet, Mia M.Gayther, Simon A.Gerdes, Anne-MarieGhoussaini, MayaGiles, Graham G.Glendon, GordGodwin, Andrew K.Goldberg, Mark S.Goldgar, David E.González-Neira, AnnaGreene, Mark H.Gronwald, JacekGuénel, PascalGunter, MarcHaeberle, LotharHaiman, Christopher A.Hamann, UteHansen, Thomas V. O.Hart, StevenHealey, SueHeikkinen, TuomasHenderson, Brian E.Herzog, JosefHogervorst, Frans B. L.Hollestelle, AntoinetteHooning, Maartje J.Hoover, Robert N.Hopper, John L.Humphreys, KeithHunter, David J.Huzarski, TomaszImyanitov, Evgeny N.Isaacs, ClaudineJakubowska, AnnaJames, PaulJanavicius, RamunasJensen, Uffe BirkJohn, Esther M.Jones, MichaelKabisch, MariaKar, SiddarthaKarlan, Beth Y.Khan, SofiaKhaw, Kay-TeeKibriya, Muhammad G.Knight, Julia A.Ko, Yon-DschunKonstantopoulou, IreneKosma, Veli-MattiKristensen, VesselaKwong, AvaLaitman, YaelLambrechts, DietherLazaro, ConxiLee, EunjungMarchand, Loic LeLester, JennyLindblom, AnnikaLindor, NoralaneLindstrom, SaraLiu, JianjunLong, JirongLubinski, JanMai, Phuong L.Makalic, EnesMalone, Kathleen E.Mannermaa, ArtoManoukian, SiranoushMargolin, SaraMarme, FrederikMartens, John W. M.McGuffog, LesleyMeindl, AlfonsMiller, AustinMilne, Roger L.Miron, PenelopeMontagna, MarcoMazoyer, SylvieMulligan, Anna M.Muranen, Taru A.Nathanson, Katherine L.Neuhausen, Susan L.Nevanlinna, HeliNordestgaard, Børge G.Nussbaum, Robert L.Offit, KennethOlah, EdithOlopade, Olufunmilayo I.Olson, Janet E.Osorio, AnaPark, Sue K.Peeters, Petra H.Peissel, BernardPeterlongo, PaoloPeto, JulianPhelan, Catherine M.Pilarski, RobertPoppe, BrucePylkäs, KatriRadice, PaoloRahman, NazneenRantala, JohannaRappaport, ChristineRennert, GadRichardson, AndreaRobson, MarkRomieu, IsabelleRudolph, AnjaRutgers, Emiel J.Sanchez, Maria-JoseSantella, Regina M.Sawyer, Elinor J.Schmidt, Daniel F.Schmidt, Marjanka K.Schmutzler, Rita K.Schumacher, FredrickScott, RodneySenter, LeighaSharma, PriyankaSimard, JacquesSinger, Christian F.Sinilnikova, Olga M.Soucy, PennySouthey, MelissaSteinemann, DorisStenmark-Askmalm, MarieStoppa-Lyonnet, DominiqueSwerdlow, AnthonySzabo, Csilla I.Tamimi, RullaTapper, WilliamTeixeira, Manuel R.Teo, Soo-HwangTerry, Mary B.Thomassen, MadsThompson, DeborahTihomirova, LaimaToland, Amanda E.Tollenaar, Robert A. E. M.Tomlinson, IanTruong, ThérèseTsimiklis, HelenTeulé, AlexTumino, RosarioTung, NadineTurnbull, ClareUrsin, Giskivan Deurzen, Carolien H. M.van Rensburg, Elizabeth J.Varon-Mateeva, RaymondaWang, ZhaomingWang-Gohrke, ShanWeiderpass, ElisabeteWeitzel, Jeffrey N.Whittemore, AliceWildiers, HansWinqvist, RobertYang, Xiaohong R.Yannoukakos, DrakoulisYao, SongZamora, M. PilarZheng, WeiHall, PerKraft, PeterVachon, CelineSlager, SusanChenevix-Trench, GeorgiaPharoah, Paul D. P.Monteiro, Alvaro A. N.García-Closas, MontserratEaston, Douglas F.Antoniou, Antonis C. et al. (Nature Publishing Group, 2016)Common variants in 94 loci have been associated with breast cancer including 15 loci with genome wide significant associations (P<5x10-8) with estrogen receptor (ER)-negative breast cancer and BRCA1-associated breast cancer ... -
Identification of four novel susceptibility loci for oestrogen receptor negative breast cancer
Couch, Fergus J.; Kuchenbaecker, Karoline B.; Michailidou, Kyriaki; Mendoza-Fandino, Gustavo A.; Nord, Silje; Lilyquist, Janna; Olswold, CurtisHallberg, EmilyAgata, SimonaAhsan, HabibulAittomäki, KristiinaAmbrosone, ChristineAndrulis, Irene L.Anton-Culver, HodaArndt, VolkerArun, Banu K.Arver, BritaBarile, MonicaBarkardottir, Rosa B.Barrowdale, DanielBeckmann, LarsBeckmann, Matthias W.Benitez, JavierBlank, Stephanie V.Blomqvist, CarlBogdanova, Natalia V.Bojesen, Stig E.Bolla, Manjeet K.Bonanni, BernardoBrauch, HiltrudBrenner, HermannBurwinkel, BarbaraBuys, Saundra S.Caldes, TrinidadCaligo, Maria A.Canzian, FedericoCarpenter, JaneChang-Claude, JennyChanock, Stephen J.Chung, Wendy K.Claes, Kathleen B. M.Cox, AngelaCross, Simon S.Cunningham, Julie M.Czene, KamilaDaly, Mary B.Damiola, FrancescaDarabi, Hatefde la Hoya, MiguelDevilee, PeterDiez, OrlandDing, Yuan C.Dolcetti, RiccardoDomchek, Susan M.Dorfling, Cecilia M.dos-Santos-Silva, IsabelDumont, MartineDunning, Alison M.Eccles, Diana M.Ehrencrona, HansEkici, Arif B.Eliassen, HeatherEllis, SteveFasching, Peter A.Figueroa, JonineFlesch-Janys, DieterFörsti, AstaFostira, FlorentiaFoulkes, William D.Friebel, TaraFriedman, EitanFrost, DebraGabrielson, MarikeGammon, Marilie D.Ganz, Patricia A.Gapstur, Susan M.Garber, JudyGaudet, Mia M.Gayther, Simon A.Gerdes, Anne-MarieGhoussaini, MayaGiles, Graham G.Glendon, GordGodwin, Andrew K.Goldberg, Mark S.Goldgar, David E.González-Neira, AnnaGreene, Mark H.Gronwald, JacekGuénel, PascalGunter, MarcHaeberle, LotharHaiman, Christopher A.Hamann, UteHansen, Thomas V. O.Hart, StevenHealey, SueHeikkinen, TuomasHenderson, Brian E.Herzog, JosefHogervorst, Frans B. L.Hollestelle, AntoinetteHooning, Maartje J.Hoover, Robert N.Hopper, John L.Humphreys, KeithHunter, David J.Huzarski, TomaszImyanitov, Evgeny N.Isaacs, ClaudineJakubowska, AnnaJames, PaulJanavicius, RamunasJensen, Uffe BirkJohn, Esther M.Jones, MichaelKabisch, MariaKar, SiddharthaKarlan, Beth Y.Khan, SofiaKhaw, Kay-TeeKibriya, Muhammad G.Knight, Julia A.Ko, Yon-DschunKonstantopoulou, IreneKosma, Veli-MattiKristensen, VesselaKwong, AvaLaitman, YaelLambrechts, DietherLazaro, ConxiLee, EunjungLe Marchand, LoicLester, JennyLindblom, AnnikaLindor, NoralaneLindstrom, SaraLiu, JianjunLong, JirongLubinski, JanMai, Phuong L.Makalic, EnesMalone, Kathleen E.Mannermaa, ArtoManoukian, SiranoushMargolin, SaraMarme, FrederikMartens, John W. M.McGuffog, LesleyMeindl, AlfonsMiller, AustinMilne, Roger L.Miron, PenelopeMontagna, MarcoMazoyer, SylvieMulligan, Anna M.Muranen, Taru A.Nathanson, Katherine L.Neuhausen, Susan L.Nevanlinna, HeliNordestgaard, Børge G.Nussbaum, Robert L.Offit, KennethOlah, EdithOlopade, Olufunmilayo I.Olson, Janet E.Osorio, AnaPark, Sue K.Peeters, Petra H.Peissel, BernardPeterlongo, PaoloPeto, JulianPhelan, Catherine M.Pilarski, RobertPoppe, BrucePylkäs, KatriRadice, PaoloRahman, NazneenRantala, JohannaRappaport, ChristineRennert, GadRichardson, AndreaRobson, MarkRomieu, IsabelleRudolph, AnjaRutgers, Emiel J.Sanchez, Maria-JoseSantella, Regina M.Sawyer, Elinor J.Schmidt, Daniel F.Schmidt, Marjanka K.Schmutzler, Rita K.Schumacher, FredrickScott, RodneySenter, LeighaSharma, PriyankaSimard, JacquesSinger, Christian F.Sinilnikova, Olga M.Soucy, PennySouthey, MelissaSteinemann, DorisStenmark-Askmalm, MarieStoppa-Lyonnet, DominiqueSwerdlow, AnthonySzabo, Csilla I.Tamimi, RullaTapper, WilliamTeixeira, Manuel R.Teo, Soo-HwangTerry, Mary B.Thomassen, MadsThompson, DeborahTihomirova, LaimaToland, Amanda E.Tollenaar, Robert A. E. M.Tomlinson, IanTruong, ThérèseTsimiklis, HelenTeulé, AlexTumino, RosarioTung, NadineTurnbull, ClareUrsin, Giskivan Deurzen, Carolien H. M.van Rensburg, Elizabeth J.Varon-Mateeva, RaymondaWang, ZhaomingWang-Gohrke, ShanWeiderpass, ElisabeteWeitzel, Jeffrey N.Whittemore, AliceWildiers, HansWinqvist, RobertYang, Xiaohong R.Yannoukakos, DrakoulisYao, SongZamora, M. PilarZheng, WeiHall, PerKraft, PeterVachon, CelineSlager, SusanChenevix-Trench, GeorgiaPharoah, Paul D. P.Monteiro, Alvaro A. N.García-Closas, MontserratEaston, Douglas F.Antoniou, Antonis C. et al. (Nature Publishing Group, 2016-04-27)Common variants in 94 loci have been associated with breast cancer including 15 loci with genome-wide significant associations (P<5 × 10$^{−8}$) with oestrogen receptor (ER)-negative breast cancer and BRCA1-associated ... -
Identification of Novel Genetic Markers of Breast Cancer Survival
Guo, Qi; Schmidt, Marjanka K.; Kraft, Peter; Canisius, Sander; Chen, Constance; Khan, Sofia; Tyrer, JonathanBolla, Manjeet K.Wang, QinDennis, JoeMichailidou, KyriakiLush, MichaelKar, SiddharthaBeesley, JonathanDunning, Alison M.Shah, MitulCzene, KamilaDarabi, HatefEriksson, MikaelLambrechts, DietherWeltens, CarolineLeunen, KarinBojesen, Stig E.Nordestgaard, Børge G.Nielsen, Sune F.Flyger, HenrikChang-Claude, JennyRudolph, AnjaSeibold, PetraFlesch-Janys, DieterBlomqvist, CarlAittomäki, KristiinaFagerholm, RainerMuranen, Taru A.Couch, Fergus J.Olson, Janet E.Vachon, CelineAndrulis, Irene L.Knight, Julia A.Glendon, GordMulligan, Anna MarieBroeks, AnnegienHogervorst, Frans B.Haiman, Christopher A.Henderson, Brian E.Schumacher, FredrickLe Marchand, LoicHopper, John L.Tsimiklis, HelenApicella, CarmelSouthey, Melissa C.Cox, AngelaCross, Simon S.Reed, Malcolm W. R.Giles, Graham G.Milne, Roger L.McLean, CatrionaWinqvist, RobertPylkäs, KatriJukkola-Vuorinen, ArjaGrip, MerviHooning, Maartje J.Hollestelle, AntoinetteMartens, John W. M.van den Ouweland, Ans M. W.Marme, FederikSchneeweiss, AndreasYang, RongxiBurwinkel, BarbaraFigueroa, JonineChanock, Stephen J.Lissowska, JolantaSawyer, Elinor J.Tomlinson, IanKerin, Michael J.Miller, NicolaBrenner, HermannDieffenbach, Aida KarinaArndt, VolkerHolleczek, BerndMannermaa, ArtoKataja, VesaKosma, Veli-MattiHartikainen, Jaana M.Li, JingmeiBrand, Judith S.Humphreys, KeithDevilee, PeterTollenaar, Rob A. E. M.Seynaeve, CarolineRadice, PaoloPeterlongo, PaoloBonanni, BernardoMariani, PaoloFasching, Peter A.Beckmann, Matthias W.Hein, AlexanderEkici, Arif B.Chenevix-Trench, GeorgiaBalleine, RosemarykConFab InvestigatorsPhillips, Kelly-AnneBenitez, JavierZamora, M. PilarArias Perez, Jose IgnacioMenéndez, PrimitivaJakubowska, AnnaLubinski, JanJaworska-Bieniek, KatarzynaDurda, KatarzynaHamann, UteKabisch, MariaUlmer, Hans UlrichRüdiger, ThomasMargolin, SaraKristensen, VesselaNord, SiljeEvans, D. GarethAbraham, Jean E.Earl, Helena M.Hiller, LouiseDunn, Janet A.Bowden, SarahBerg, ChristineCampa, DanieleDiver, W. RyanGapstur, Susan M.Gaudet, Mia M.Hankinson, Susan E.Hoover, Robert N.Hüsing, AnikaKaaks, RudolfMachiela, Mitchell J.Willett, WalterBarrdahl, MyrtoCanzian, FedericoChin, Suet-FeungCaldas, CarlosHunter, David J.Lindstrom, SaraGarcía-Closas, MontserratHall, PerEaston, Douglas F.Eccles, Diana M.Rahman, NazneenNevanlinna, HeliPharoah, Paul D. P. et al. (Oxford Journals, 2015-04-18)Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with ... -
The INSIG2 rs7566605 polymorphism is not associated with body mass index and breast cancer risk
Campa, Daniele; Husing, Anika; McKay, James D.; Sinilnikova, Olga M.; Vogel, Ulla; Tjonneland, Anne; Overvad, KimStegger, JakobClavel-Chapelon, FrançoiseChabbert-Buffet, NathalieFagherazzi, GuyTrichopoulou, AntoniaZylis, DimosthenisOustoglou, ErifiliRohrmann, SabineTeucher, BirgitFisher, EvaBoeing, HeinerMasala, GiovannaKrogh, VittorioSacerdote, CarlottaPanico, SalvatoreTumino, RosarioOnland-Moret, N. Charlottevan Gils, Carla H.Bueno-de-Mesquita, H. BasLund, EilivChirlaque, Maria-DoloresSala, NuriaQuiros, Jose R.Ardanaz, EvaAmiano, PilarMolina-Montes, EstherHallmans, GoranLenner, PerTravis, Ruth C.Key, Timothy J.Wareham, Nicholas J.Khaw, Kay-TeeRinaldi, SabinaSlimani, NadiaChajes, VeroniqueSiddiq, AfshanRiboli, ElioKaaks, RudolfCanzian, Federico et al. (2010-10-18)Abstract Background The single nucleotide polymorphism rs7566605, located in the promoter of the INSIG2 gene, has been the subject of a strong scientific effort aimed to elucidate its possible association with body mass ...