Now showing items 1-12 of 12

    • Copy number: Efficient algorithms for single- and multi-track copy number segmentation 

      Nilsen, Gro; Liestøl, Knut; Loo, Peter Van; Moen Vollan, Hans Kristian; Eide, Marianne B.; Rueda, Oscar M.; Chin, Suet-Feung et al. (2012-11-04)
      Abstract Background Cancer progression is associated with genomic instability and an accumulation of gains and losses of DNA. The growing variety of tools for measuring genomic copy numbers, including various types of ...
    • Effects of BRCA2 cis-regulation in normal breast and cancer risk amongst BRCA2 mutation carriers 

      Maia, Ana-Teresa; Antoniou, Antonis C.; O'Reilly, Martin; Samarajiwa, Shamith; Dunning, Mark; Kartsonaki, Christiana; Chin, Suet-Feung et al. (2012-04-18)
      Abstract Introduction Cis-acting regulatory single nucleotide polymorphisms (SNPs) at specific loci may modulate penetrance of germline mutations at the same loci by introducing different levels of expression of the wild-type ...
    • High-resolution aCGH and expression profiling identifies a novel genomic subtype of ER negative breast cancer 

      Chin, Suet-Feung; Teschendorff, Andrew E.; Marioni, John C.; Wang, Yanzhong; Barbosa-Morais, Nuno L.; Thorne, Natalie P.; Costa, Jose L. et al. (2007-10-07)
      Abstract Background The characterization of copy number alteration patterns in breast cancer requires high-resolution genome-wide profiling of a large panel of tumor specimens. To date, most genome-wide array comparative ...
    • High-resolution array CGH clarifies events occurring on 8p in carcinogenesis 

      Cooke, Susanna L.; Pole, Jessica C. M.; Chin, Suet-Feung; Ellis, Ian O.; Caldas, Carlos; Edwards, Paul A. W. (2008-10-07)
      Abstract Background Rearrangement of the short arm of chromosome 8 (8p) is very common in epithelial cancers such as breast cancer. Usually there is an unbalanced translocation breakpoint in 8p12 (29.7 Mb – 38.5 Mb) with ...
    • Identification of Novel Genetic Markers of Breast Cancer Survival 

      Guo, Qi; Schmidt, Marjanka K.; Kraft, Peter; Canisius, Sander; Chen, Constance; Khan, Sofia; Tyrer, Jonathan et al. (Oxford Journals, 2015-04-18)
      Background: Survival after a diagnosis of breast cancer varies considerably between patients, and some of this variation may be because of germline genetic variation. We aimed to identify genetic markers associated with ...
    • Master regulators of FGFR2 signalling and breast cancer risk 

      Fletcher, Michael N. C.; Castro, Mauro A. A.; Wang, Xin; de Santiago, Ines; O'Reilly, Martin; Chin, Suet-Feung; Rueda, Oscar M. et al. (NPG, 2013-09-17)
      The fibroblast growth factor receptor 2 (FGFR2) locus has been consistently identified as a breast cancer risk locus in independent genome-wide association studies. However, the molecular mechanisms underlying FGFR2-mediated ...
    • MicroRNA expression profiling of human breast cancer identifies new markers of tumour subtype 

      Blenkiron, Cherie; Goldstein, Leonard D.; Thorne, Natalie P.; Spiteri, Inmaculada; Chin, Suet-Feung; Dunning, Mark J.; Barbosa-Morais, Nuno L. et al. (2007-10-08)
      Abstract Background MicroRNAs (miRNAs), a class of short non-coding RNAs found in many plants and animals, often act post-transcriptionally to inhibit gene expression. Results Here we report the analysis of miRNA expression ...
    • Multifocal clonal evolution characterized using circulating tumor DNA in a case of metastatic breast cancer 

      Murtaza, Muhammed; Dawson, Sarah-­Jane; Pogrebniak, Katherine; Rueda, Oscar M.; Provenzano, Elena; Grant, John; Chin, Suet-Feung et al. (Nature Publishing Group, 2015-11-04)
      Circulating tumour DNA analysis can be used to track tumour burden and analyse cancer genomes non-invasively but the extent to which it represents metastatic heterogeneity is unknown. Here we follow a patient with metastatic ...
    • PMC42, a breast progenitor cancer cell line, has normal-like mRNA and miRNA transcriptomes 

      Git, Anna; Spiteri, Inmaculada; Blenkiron, Cherie; Dunning, Mark J.; Pole, Jessica C. M.; Chin, Suet-Feung; Wang, Yanzhong et al. (2008-06-27)
      Abstract Introduction The use of cultured cell lines as model systems for normal tissue is limited by the molecular alterations accompanying the immortalisation process, including changes in the mRNA and microRNA (miRNA) ...
    • The somatic mutation profiles of 2500 primary breast cancers refine their genomic landscapes 

      Pereira, Bernard; Chin, Suet-Feung; Rueda, Oscar M.; Vollan, Hans-Kristian Moen; Provenzano, Elena; Bardwell, Helen A.; Pugh, Michelle et al. (Nature Publishing Group, 2016)
      The somatic mutation landscape in breast cancer is complex, and inter- and intra-tumour genomic heterogeneity are important clinical challenges. We performed targeted resequencing of 173 breast cancer-related genes in ...
    • Structural analysis of the genome of breast cancer cell line ZR-75-30 identifies twelve expressed fusion genes 

      Schulte, Ina; Batty, Elizabeth M.; Pole, Jessica C. M.; Blood, Katherine A.; Mo, Steven; Cooke, Susanna L.; Ng, Charlotte et al. (2012-12-22)
      Abstract Background It has recently emerged that common epithelial cancers such as breast cancers have fusion genes like those in leukaemias. In a representative breast cancer cell line, ZR-75-30, we searched for fusion ...
    • Subtype-specific micro-RNA expression signatures in breast cancer progression 

      Haakensen, Vilde D.; Nygaard, Vegard; Gregers, Liliana; Aure, Miriam R.; Fromm, Bastian; Bukholm, Ida R. K.; Lüders, Torben et al. (Wiley, 2016-04-15)
      Robust markers of invasiveness may help reduce the overtreatment of in situ carcinomas. Breast cancer is a heterogeneous disease and biological mechanisms for carcinogenesis vary between subtypes. Stratification by subtype ...