Now showing items 1-20 of 47

    • The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease 

      Astle, William John; Elding, H; Jiang, T; Allen, D; Ruklisa, Dace; Mann, AL; Mead, D et al. (Elsevier, 2016-11-17)
      Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL ...
    • ANGPTL3 Deficiency and Protection Against Coronary Artery Disease 

      Stitziel, NO; Khera, AV; Wang, X; Bierhals, AJ; Vourakis, AC; Sperry, AE; Natarajan, P et al. (Elsevier, 2017-04-25)
      Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). ...
    • Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. 

      Saleheen, Danish; Haycock, Philip C; Zhao, Wei; Rasheed, Asif; Taleb, Adam; Imran, Atif; Abbas, Shahid et al. (2017-07)
    • Association analyses based on false discovery rate implicate new loci for coronary artery disease 

      Nelson, CP; Goel, A; Butterworth, Adam Stuart; Kanoni, S; Webb, TR; Marouli, E; Zeng, L et al.
      Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10(-8)) at the time of this analysis, but a much larger number of putative loci at a ...
    • Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis 

      Chowdhury, Rajiv; Warnakula, Samantha; Kunutsor, Setor; Crowe, Francesca; Ward, Heather A; Johnson, Laura; Franco, Oscar H et al. (2014-03-18)
    • Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk 

      Ference, BA; Kastelein, JJP; Ginsberg, HN; Chapman, MJ; Nicholls, SJ; Ray, KK; Packard, CJ et al. (American Medical Association, 2017-09-12)
      Importance: Some cholesteryl ester transfer protein (CETP) inhibitors lower low-density lipoprotein cholesterol (LDL-C) levels without reducing cardiovascular events, suggesting that the clinical benefit of lowering LDL-C ...
    • The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes - the EPIC-InterAct Study 

      Podmore, Clara; Meidtner, Karina; Schulze, Matthias B; Scott, Robert; Ramond, Anna; Butterworth, Adam Stuart; di, Angelantonio Emanuele et al. (2016-02-09)
    • The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design 

      Chowdhury, Rajiv; Alam, Dewan S; Fakir, Ismail Ibrahim; Adnan, Sheikh Daud; Naheed, Aliya; Tasmin, Ishrat; Monower, Md Mostafa et al. (2015-05-01)
    • Body-mass index and all-cause mortality - Authors' reply. 

      Di Angelantonio, Emanuele; Bhupathiraju, Shilpa N; Hu, Frank B; Danesh, John; Peto, Richard; Lewington, Sarah; Global BMI Mortality Collaboration, (2017-06)
    • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents 

      di, Angelantonio Emanuele; Bhupathiraju, Shilpa N; Wormser, David; Gao, Pei; Kaptoge, Stephen Kipkemoi; Berrington, de Gonzalez Amy; Cairns, Benjamin J et al. (2016-07-13)
    • BRCA2 Variants and cardiovascular disease in a multi-ethnic study 

      Zbuk, Kevin; Xie, Changchun; Young, Robin; Heydarpour, Mahyar; Pare, Guillaume; Davis, AD; Miller, Ruby et al. (2012-07-18)
    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin, 1 Genetics Consortium; Freitag, Daniel Franz; Butterworth, Adam Stuart; Willeit, Peter; Howson, Joanna McCammond; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (2015-02-26)
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; König, Inke R; Weeke, Peter E et al. (2016-03-02)
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease (vol 374, pg 1134, 2016) 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; Koenig, Inke R; Weeke, Peter E et al. (2016-05-12)
    • Commentary on "A meta-analysis but not a systematic review: an evaluation of the Global BMI Mortality Collaboration". 

      Bhupathiraju, Shilpa N; Di Angelantonio, Emanuele; Danesh, John; Hu, Frank B (2017-08)
    • Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing. 

      Sifrim, Alejandro; Hitz, Marc-Phillip; Wilsdon, Anna; Breckpot, Jeroen; Turki, Saeed H Al; Thienpont, Bernard; McRae, Jeremy et al. (2016-09)
    • Efficiency and safety of varying the frequency of whole blood donation: randomised trial of 45,000 donors 

      Di Angelantonio, E; Thompson, SG; Kaptoge, S; Moore, C; Walker, M; Danesh, John; Ouwehand, W
      Background Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed. We compared ...
    • Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms 

      Howson, Joanna McCammond; Zhao, W; Barnes, Daniel Robert; Ho, W-K; Young, R; Paul, Dirk Stefan; Waite, LL et al.
      Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional ...
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...