Now showing items 1-20 of 24

    • The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease 

      Astle, William John; Elding, H; Jiang, T; Allen, D; Ruklisa, Dace; Mann, AL; Mead, D et al. (Elsevier, 2016-11-17)
      Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL ...
    • Association analyses based on false discovery rate implicate new loci for coronary artery disease 

      Nelson, CP; Goel, A; Butterworth, Adam Stuart; Kanoni, S; Webb, TR; Marouli, E; Zeng, L et al.
      Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10(-8)) at the time of this analysis, but a much larger number of putative loci at a ...
    • Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis 

      Chowdhury, Rajiv; Warnakula, Samantha; Kunutsor, Setor; Crowe, Francesca; Ward, Heather A.; Johnson, Laura; Franco, Oscar H. et al. (American College of Physicians, 2014-03-18)
      Background: Guidelines advocate changes in fatty acid consumption to promote cardiovascular health. Purpose: To summarize evidence about associations between fatty acids and coronary disease. Data Sources: MEDLINE, ...
    • The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes - the EPIC-InterAct Study 

      Podmore, Clara; Meidtner, Karina; Schulze, Matthias B.; Scott, Robert A.; Ramond, Anna; Butterworth, Adam S.; di Angelantonio, Emanuele et al. (American Diabetes Association, 2016-02-09)
      Objective: Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores for T2D development. However, ferritin is influenced by factors other than iron stores, ...
    • The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design 

      Chowdhury, Rajiv; Alam, Dewan S.; Fakir, Ismail Ibrahim; Adnan, Sheikh Daud; Naheed, Aliya; Tasmin, Ishrat; Monower, Md Mostafa et al. (Springer, 2015-05-01)
      During recent decades, Bangladesh has experienced a rapid epidemiological transition from communicable to non-communicable diseases. Coronary heart disease (CHD), with myocardial infarction (MI) as its main manifestation, ...
    • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents 

      di Angelantonio, Emanuele; Bhupathiraju, Shilpa N.; Wormser, David; Gao, Pei; Kaptoge, Stephen; Berrington de Gonzalez, Amy; Cairns, Benjamin J. et al. (Elsevier, 2016-07-13)
      Background: Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant-data meta-analyses of the prospective studies of body ...
    • BRCA2 Variants and cardiovascular disease in a multi-ethnic study 

      Zbuk, Kevin; Xie, Changchun; Young, Robin; Heydarpour, Mahyar; Pare, Guillaume; Davis, A. D.; Miller, Ruby et al. (2012-07-18)
      AbstractBackgroundGermline mutations of BRCA1/2 are associated with hereditary breast and ovarian cancer. Recent data suggests excess mortality in mutation carriers beyond that conferred by neoplasia, and recent in vivo ...
    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin 1 Genetics Consortium; Freitag, Daniel F.; Butterworth, Adam S.; Willeit, Peter; Howson, Joanna M. M.; Burgess, Stephen; Kaptoge, Stephen et al. (Elsevier, 2015-02-26)
      Background:To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of ...
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease 

      Stitziel, Nathan O.; Stirrups, Kathleen E.; Masca, Nicholas G. D.; Erdmann, Jeanette; Ferrario, Paola G.; König, Inke R.; Weeke, Peter E. et al. (Massachusetts Medical Society, 2016-03-02)
      BACKGROUND The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS Through DNA genotyping, we tested 54,003 ...
    • Genetic invalidation of Lp-PLA$_{2}$ as a therapeutic target: Large-scale study of five functional Lp-PLA$_{2}$-lowering alleles 

      Gregson, JM; Freitag, DF; Surendran, Praveen; Stitziel, NO; Chowdhury, Rajiv; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (SAGE Publications Ltd, 2017-03-01)
      $\textbf{Aims}$ Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A$_{2}$ (Lp-PLA$_{2}$), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether ...
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P.; Hamby, Stephen E.; Saleheen, Danish; Hopewell, Jenna C.; Zeng, Lingyao; Assimes, Themistocles L.; Kanoni, Stavroula et al. (Massachusetts Medical Society, 2015-04-23)
      The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a genetic approach to investigate the association between ...
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert A.; Freitag, Daniel F.; Li, Li; Chu, Audrey Y.; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (American Association for the Advancement of Science, 2016-06-01)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Inflammatory Cytokines and Risk of Coronary Heart Disease: New Prospective Study and Updated Meta-Analysis 

      Kaptoge, Stephen; Seshasai, Sreenivasa Rao Kondapally; Gao, Pei; Freitag, Daniel F.; Butterworth, Adam S.; Borglykke, Anders; Di Angelantonio, Emanuele et al. (Oxford Journals, 2013-09-11)
      Aims Because low-grade inflammation may play a role in the pathogenesis of coronary heart disease (CHD), and pro-inflammatory cytokines govern inflammatory cascades, this study aimed to assess the associations of several ...
    • Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour 

      Silarova, Barbora; Lucas, Joanne; Butterworth, Adam S; Di Angelantonio, Emanuele; Girling, Christine; Lawrence, Kathryn; Mackintosh, Stuart et al. (2015-09-07)
      Abstract Background Cardiovascular disease (CVD) remains the leading cause of death globally. Primary prevention of CVD requires cost-effective strategies to identify individuals ...
    • Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour 

      Silarova, Barbora; Lucas, Joanne; Butterworth, Adam S.; Di Angelantonio, Emanuele; Girling, Christine; Lawrence, Kathryn; Mackintosh, Stuart et al. (BioMed Central, 2015)
      Background: Cardiovascular disease (CVD) remains the leading cause of death globally. Primary prevention of CVD requires cost-effective strategies to identify individuals at high risk in order to help target preventive ...
    • The INTERVAL Trial to determine whether intervals between blood donations can be safely and acceptably decreased to optimise blood supply: study protocol for a randomised controlled trial 

      Moore, Carmel; Sambrook, Jennifer; Walker, Matthew; Tolkien, Zoe; Kaptoge, Stephen; Allen, David; Mehenny, Susan et al. (BioMed Central, 2014-09-17)
      Background Ageing populations may demand more blood transfusions, but the blood supply could be limited by difficulties in attracting and retaining a decreasing pool of younger donors. One approach to increase blood ...
    • Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study 

      Peters, SA; van der Schouw, YT; Wood, Angela Mary; Sweeting, Michael John; Moons, KG; Weiderpass, E; Arriola, L et al. (SAGE Publications Ltd, 2016-11)
      OBJECTIVE: There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity ...
    • PhenoScanner: a database of human genotype-phenotype associations 

      Staley, James R.; Blackshaw, James; Kamat, Mihir A.; Ellis, Steve; Surendran, Praveen; Sun, Benjamin B.; Paul, Dirk S. et al. (Oxford University Press, 2016)
      PhenoScanner is a curated database of publicly available results from large-scale genetic association studies. This tool aims to facilitate “phenome scans”, the cross-referencing of genetic variants with many phenotypes, ...
    • Rare and low-frequency coding variants alter human adult height 

      Stirrups, Kathleen Elizabeth; Butterworth, Adam Stuart; Chowdhury, Rajiv; Danesh, John; Di Angelantonio, Emanuele; Howson, Joanna McCammond; Surendran, Praveen et al. (Nature Publishing Group, 2017-02-09)
      Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome-wide association studies. Here, we report 83 new height-associated coding variants with lower minor ...
    • Recruitment and representativeness of blood donors in the INTERVAL randomised trial assessing varying inter-donation intervals 

      Moore, Carmel; Bolton, Thomas; Walker, Matthew; Kaptoge, Stephen; Allen, David; Daynes, Michael; Mehenny, Susan et al. (BioMed Central, 2016-09-20)
      Background The interpretation of trial results can be helped by understanding how generalisable they are to the target population for which inferences are intended. INTERVAL, a large pragmatic randomised trial of blood ...