Now showing items 1-20 of 37

    • The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease 

      Astle, William John; Elding, H; Jiang, T; Allen, D; Ruklisa, Dace; Mann, AL; Mead, D et al. (Elsevier, 2016-11-17)
      Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL ...
    • ANGPTL3 Deficiency and Protection Against Coronary Artery Disease 

      Stitziel, NO; Khera, AV; Wang, X; Bierhals, AJ; Vourakis, AC; Sperry, AE; Natarajan, P et al. (Elsevier, 2017-04-25)
      Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). ...
    • Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. 

      Saleheen, Danish; Haycock, Philip C; Zhao, Wei; Rasheed, Asif; Taleb, Adam; Imran, Atif; Abbas, Shahid et al. (2017-07)
    • Association analyses based on false discovery rate implicate new loci for coronary artery disease 

      Nelson, CP; Goel, A; Butterworth, Adam Stuart; Kanoni, S; Webb, TR; Marouli, E; Zeng, L et al.
      Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10(-8)) at the time of this analysis, but a much larger number of putative loci at a ...
    • Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis 

      Chowdhury, Rajiv; Warnakula, Samantha; Kunutsor, Setor; Crowe, Francesca; Ward, Heather A; Johnson, Laura; Franco, Oscar H et al. (2014-03-18)
    • The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes - the EPIC-InterAct Study 

      Podmore, Clara; Meidtner, Karina; Schulze, Matthias B; Scott, Robert; Ramond, Anna; Butterworth, Adam Stuart; di, Angelantonio Emanuele et al. (2016-02-09)
    • The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design 

      Chowdhury, Rajiv; Alam, Dewan S; Fakir, Ismail Ibrahim; Adnan, Sheikh Daud; Naheed, Aliya; Tasmin, Ishrat; Monower, Md Mostafa et al. (2015-05-01)
    • Body-mass index and all-cause mortality - Authors' reply. 

      Di Angelantonio, Emanuele; Bhupathiraju, Shilpa N; Hu, Frank B; Danesh, John; Peto, Richard; Lewington, Sarah; Global BMI Mortality Collaboration, (2017-06)
    • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents 

      di, Angelantonio Emanuele; Bhupathiraju, Shilpa N; Wormser, David; Gao, Pei; Kaptoge, Stephen Kipkemoi; Berrington, de Gonzalez Amy; Cairns, Benjamin J et al. (2016-07-13)
    • BRCA2 Variants and cardiovascular disease in a multi-ethnic study 

      Zbuk, Kevin; Xie, Changchun; Young, Robin; Heydarpour, Mahyar; Pare, Guillaume; Davis, AD; Miller, Ruby et al. (2012-07-18)
    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin, 1 Genetics Consortium; Freitag, Daniel Franz; Butterworth, Adam Stuart; Willeit, Peter; Howson, Joanna McCammond; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (2015-02-26)
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; König, Inke R; Weeke, Peter E et al. (2016-03-02)
    • Efficiency and safety of varying the frequency of whole blood donation: randomised trial of 45,000 donors 

      Di Angelantonio, E; Thompson, SG; Kaptoge, S; Moore, C; Walker, M; Danesh, John; Ouwehand, W
      Background Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed. We compared ...
    • Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms 

      Howson, Joanna McCammond; Zhao, W; Barnes, Daniel Robert; Ho, W-K; Young, R; Paul, Dirk Stefan; Waite, LL et al.
      Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional ...
    • Genetic invalidation of Lp-PLA$_{2}$ as a therapeutic target: Large-scale study of five functional Lp-PLA$_{2}$-lowering alleles 

      Gregson, JM; Freitag, DF; Surendran, Praveen; Stitziel, NO; Chowdhury, Rajiv; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (SAGE Publications Ltd, 2017-03-01)
      $\textbf{Aims}$ Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A$_{2}$ (Lp-PLA$_{2}$), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether ...
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P; Hamby, Stephen E; Saleheen, Danish; Hopewell, Jenna C; Zeng, Lingyao; Assimes, Themistocles L; Kanoni, Stavroula et al. (2015-04-23)
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert; Freitag, Daniel F; Li, Li; Chu, Audrey Y; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (2016-06-01)
    • Genomics of lipid metabolism: Identifying novel causal pathways and new therapeutic targets for reducing risk of coronary heart disease 

      Harshfield, Eric; Stacey, D; Paul, Dirk Stefan; Koulman, Albert; Wood, Angela Mary; Butterworth, Adam Stuart; Fauman, EB et al. (John Wiley & Sons Inc., 2016-09-28)
      Coronary heart disease (CHD) is one of the leading causes of death worldwide; mortality rates are expected to continue to rise over the coming decades. Circulating lipids have been shown to be strongly and linearly associated ...
    • Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity 

      Saleheen, D; Natarajan, P; Armean, IM; Zhao, W; Rasheed, A; Khetarpal, SA; Won, H-H et al. (Nature Publishing Group, 2017-04-13)
      A major goal of biomedicine is to understand the function of every gene in the human genome. Loss-of-function mutations can disrupt both copies of a given gene in humans and phenotypic analysis of such 'human knockouts' ...