Now showing items 1-20 of 59

    • The Allelic Landscape of Human Blood Cell Trait Variation and Links to Common Complex Disease 

      Astle, William John; Elding, H; Jiang, T; Allen, D; Ruklisa, Dace; Mann, AL; Mead, D et al. (Elsevier, 2016-11-17)
      Many common variants have been associated with hematological traits, but identification of causal genes and pathways has proven challenging. We performed a genome-wide association analysis in the UK Biobank and INTERVAL ...
    • Analysis of protein-coding genetic variation in 60,706 humans. 

      Lek, Monkol; Karczewski, Konrad J; Minikel, Eric V; Samocha, Kaitlin E; Banks, Eric; Fennell, Timothy; O'Donnell-Luria, Anne H et al. (2016-08-17)
    • ANGPTL3 Deficiency and Protection Against Coronary Artery Disease 

      Stitziel, NO; Khera, AV; Wang, X; Bierhals, AJ; Vourakis, AC; Sperry, AE; Natarajan, P et al. (Elsevier, 2017-04-25)
      Background Familial combined hypolipidemia, a Mendelian condition characterized by substantial reductions in all 3 major lipid fractions, is caused by mutations that inactivate the gene angiopoietin-like 3 (ANGPTL3). ...
    • Apolipoprotein(a) isoform size, lipoprotein(a) concentration, and coronary artery disease: a mendelian randomisation analysis. 

      Saleheen, Danish; Haycock, Philip C; Zhao, Wei; Rasheed, Asif; Taleb, Adam; Imran, Atif; Abbas, Shahid et al. (2017-07)
    • Association analyses based on false discovery rate implicate new loci for coronary artery disease 

      Nelson, CP; Goel, A; Butterworth, Adam Stuart; Kanoni, S; Webb, TR; Marouli, E; Zeng, L et al.
      Genome-wide association studies (GWAS) in coronary artery disease (CAD) had identified 66 loci at 'genome-wide significance' (P < 5 × 10(-8)) at the time of this analysis, but a much larger number of putative loci at a ...
    • The association between psychiatric diagnosis and violent re-offending in adult offenders in the community 

      Grann, Martin; Danesh, John; Fazel, Seena (2008-11-25)
      Abstract Background High rates of repeat offending are common across nations that are socially and culturally different. Although psychiatric disorders are believed to be risk factors for violent reoffending, the available ...
    • Association of Dietary, Circulating, and Supplement Fatty Acids With Coronary Risk: A Systematic Review and Meta-analysis 

      Chowdhury, Rajiv; Warnakula, Samantha; Kunutsor, Setor; Crowe, Francesca; Ward, Heather A; Johnson, Laura; Franco, Oscar H et al. (American College of Physicians, 2014-03-18)
      Background: Guidelines advocate changes in fatty acid consumption to promote cardiovascular health. Purpose: To summarize evidence about associations between fatty acids and coronary disease. Data Sources: MEDLINE, Science ...
    • Association of Genetic Variants Related to CETP Inhibitors and Statins With Lipoprotein Levels and Cardiovascular Risk 

      Ference, BA; Kastelein, JJP; Ginsberg, HN; Chapman, MJ; Nicholls, SJ; Ray, KK; Packard, CJ et al. (American Medical Association, 2017-09-12)
      Importance: Some cholesteryl ester transfer protein (CETP) inhibitors lower low-density lipoprotein cholesterol (LDL-C) levels without reducing cardiovascular events, suggesting that the clinical benefit of lowering LDL-C ...
    • The Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes - the EPIC-InterAct Study 

      Podmore, Clara; Meidtner, Karina; Schulze, Matthias B; Scott, Robert; Ramond, Anna; Butterworth, Adam Stuart; di, Angelantonio Emanuele et al. (American Diabetes Association, 2016-02-09)
      Objective: Observational studies show an association between ferritin and type 2 diabetes (T2D), suggesting a role of high iron stores for T2D development. However, ferritin is influenced by factors other than iron stores, ...
    • The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design 

      Chowdhury, Rajiv; Alam, Dewan S; Fakir, Ismail Ibrahim; Adnan, Sheikh Daud; Naheed, Aliya; Tasmin, Ishrat; Monower, Md Mostafa et al. (Springer, 2015-05-01)
      During recent decades, Bangladesh has experienced a rapid epidemiological transition from communicable to non-communicable diseases. Coronary heart disease (CHD), with myocardial infarction (MI) as its main manifestation, ...
    • Body-mass index and all-cause mortality - Authors' reply. 

      Di Angelantonio, Emanuele; Bhupathiraju, Shilpa N; Hu, Frank B; Danesh, John; Peto, Richard; Lewington, Sarah; Global BMI Mortality Collaboration, (2017-06)
    • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents 

      di, Angelantonio Emanuele; Bhupathiraju, Shilpa N; Wormser, David; Gao, Pei; Kaptoge, Stephen Kipkemoi; Berrington, de Gonzalez Amy; Cairns, Benjamin J et al. (Elsevier, 2016-07-13)
      Background: Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant-data meta-analyses of the prospective studies of body ...
    • BRCA2 Variants and cardiovascular disease in a multi-ethnic study 

      Zbuk, Kevin; Xie, Changchun; Young, Robin; Heydarpour, Mahyar; Pare, Guillaume; Davis, AD; Miller, Ruby et al. (2012-07-18)
      AbstractBackgroundGermline mutations of BRCA1/2 are associated with hereditary breast and ovarian cancer. Recent data suggests excess mortality in mutation carriers beyond that conferred by neoplasia, and recent in vivo ...
    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin, 1 Genetics Consortium; Freitag, Daniel Franz; Butterworth, Adam Stuart; Willeit, Peter; Howson, Joanna McCammond; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (Elsevier, 2015-02-26)
      Background:To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of ...
    • Chronic disease research in Europe and the need for integrated population cohorts 

      Danesh, John
      The burden of chronic diseases in Europe is sure to increase in coming decades, due primarily to an aging European population. This will place an enormous burden on national health budgets that are already constrained and ...
    • Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. 

      Jaiswal, Siddhartha; Natarajan, Pradeep; Silver, Alexander J; Gibson, Christopher J; Bick, Alexander G; Shvartz, Eugenia; McConkey, Marie et al. (2017-07)
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; König, Inke R; Weeke, Peter E et al. (Massachusetts Medical Society, 2016-03-02)
      BACKGROUND The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS Through DNA genotyping, we tested 54,003 ...
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease (vol 374, pg 1134, 2016) 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; Koenig, Inke R; Weeke, Peter E et al. (2016-05-12)
    • Commentary on "A meta-analysis but not a systematic review: an evaluation of the Global BMI Mortality Collaboration". 

      Bhupathiraju, Shilpa N; Di Angelantonio, Emanuele; Danesh, John; Hu, Frank B (2017-08)
    • Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing. 

      Sifrim, Alejandro; Hitz, Marc-Phillip; Wilsdon, Anna; Breckpot, Jeroen; Turki, Saeed H Al; Thienpont, Bernard; McRae, Jeremy et al. (2016-09)