Now showing items 10-29 of 59

    • The Bangladesh Risk of Acute Vascular Events (BRAVE) Study: objectives and design 

      Chowdhury, Rajiv; Alam, Dewan S; Fakir, Ismail Ibrahim; Adnan, Sheikh Daud; Naheed, Aliya; Tasmin, Ishrat; Monower, Md Mostafa et al. (Springer, 2015-05-01)
      During recent decades, Bangladesh has experienced a rapid epidemiological transition from communicable to non-communicable diseases. Coronary heart disease (CHD), with myocardial infarction (MI) as its main manifestation, ...
    • Body-mass index and all-cause mortality - Authors' reply. 

      Di Angelantonio, Emanuele; Bhupathiraju, Shilpa N; Hu, Frank B; Danesh, John; Peto, Richard; Lewington, Sarah; Global BMI Mortality Collaboration, (2017-06)
    • Body-mass index and all-cause mortality: individual-participant-data meta-analysis of 239 prospective studies in four continents 

      di, Angelantonio Emanuele; Bhupathiraju, Shilpa N; Wormser, David; Gao, Pei; Kaptoge, Stephen Kipkemoi; Berrington, de Gonzalez Amy; Cairns, Benjamin J et al. (Elsevier, 2016-07-13)
      Background: Overweight and obesity are increasing worldwide. To help assess their relevance to mortality in different populations we conducted individual-participant-data meta-analyses of the prospective studies of body ...
    • BRCA2 Variants and cardiovascular disease in a multi-ethnic study 

      Zbuk, Kevin; Xie, Changchun; Young, Robin; Heydarpour, Mahyar; Pare, Guillaume; Davis, AD; Miller, Ruby et al. (2012-07-18)
      AbstractBackgroundGermline mutations of BRCA1/2 are associated with hereditary breast and ovarian cancer. Recent data suggests excess mortality in mutation carriers beyond that conferred by neoplasia, and recent in vivo ...
    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin, 1 Genetics Consortium; Freitag, Daniel Franz; Butterworth, Adam Stuart; Willeit, Peter; Howson, Joanna McCammond; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (Elsevier, 2015-02-26)
      Background:To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of ...
    • Chronic disease research in Europe and the need for integrated population cohorts 

      Danesh, John
      The burden of chronic diseases in Europe is sure to increase in coming decades, due primarily to an aging European population. This will place an enormous burden on national health budgets that are already constrained and ...
    • Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease. 

      Jaiswal, Siddhartha; Natarajan, Pradeep; Silver, Alexander J; Gibson, Christopher J; Bick, Alexander G; Shvartz, Eugenia; McConkey, Marie et al. (2017-07)
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; König, Inke R; Weeke, Peter E et al. (Massachusetts Medical Society, 2016-03-02)
      BACKGROUND The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS Through DNA genotyping, we tested 54,003 ...
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease (vol 374, pg 1134, 2016) 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; Koenig, Inke R; Weeke, Peter E et al. (2016-05-12)
    • Commentary on "A meta-analysis but not a systematic review: an evaluation of the Global BMI Mortality Collaboration". 

      Bhupathiraju, Shilpa N; Di Angelantonio, Emanuele; Danesh, John; Hu, Frank B (2017-08)
    • Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing. 

      Sifrim, Alejandro; Hitz, Marc-Phillip; Wilsdon, Anna; Breckpot, Jeroen; Turki, Saeed H Al; Thienpont, Bernard; McRae, Jeremy et al. (2016-09)
    • Efficiency and safety of varying the frequency of whole blood donation: randomised trial of 45,000 donors 

      Di Angelantonio, E; Thompson, SG; Kaptoge, S; Moore, C; Walker, M; Danesh, John; Ouwehand, W
      Background Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed. We compared ...
    • Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms 

      Howson, Joanna McCammond; Zhao, W; Barnes, Daniel Robert; Ho, W-K; Young, R; Paul, Dirk Stefan; Waite, LL et al.
      Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional ...
    • Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference. 

      Corbin, Laura J; Tan, Vanessa Y; Hughes, David A; Wade, Kaitlin H; Paul, Dirk Stefan; Tansey, Katherine E; Butcher, Frances et al. (Springer Nature, 2018-02-19)
      Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks ...
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic invalidation of Lp-PLA$_{2}$ as a therapeutic target: Large-scale study of five functional Lp-PLA$_{2}$-lowering alleles 

      Gregson, JM; Freitag, DF; Surendran, Praveen; Stitziel, NO; Chowdhury, Rajiv; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (SAGE Publications Ltd, 2017-03-01)
      $\textbf{Aims}$ Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A$_{2}$ (Lp-PLA$_{2}$), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether ...
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 

      International Consortium for Blood Pressure Genome-Wide Association Studies,; Ehret, Georg B; Munroe, Patricia B; Rice, Kenneth M; Bochud, Murielle; Johnson, Andrew D; Chasman, Daniel I et al. (2011-09-11)
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P; Hamby, Stephen E; Saleheen, Danish; Hopewell, Jenna C; Zeng, Lingyao; Assimes, Themistocles L; Kanoni, Stavroula et al. (Massachusetts Medical Society, 2015-04-23)
      The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a genetic approach to investigate the association between height ...
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)
    • Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. 

      Jiang, Xia; O'Reilly, Paul F; Aschard, Hugues; Aschard, Hugues; Hsu, Yi-Hsiang; Richards, J Brent; Dupuis, Josée et al. (2018-01-17)
      Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, ...