Now showing items 15-34 of 64

    • Cardiometabolic effects of genetic upregulation of the interleukin 1 receptor antagonist: a Mendelian randomisation analysis 

      Interleukin, 1 Genetics Consortium; Freitag, Daniel Franz; Butterworth, Adam Stuart; Willeit, Peter; Howson, Joanna McCammond; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (Elsevier, 2015-02-26)
      Background:To investigate potential cardiovascular and other effects of long-term pharmacological interleukin 1 (IL-1) inhibition, we studied genetic variants that produce inhibition of IL-1, a master regulator of ...
    • Chronic disease research in Europe and the need for integrated population cohorts 

      Danesh, John
      The burden of chronic diseases in Europe is sure to increase in coming decades, due primarily to an aging European population. This will place an enormous burden on national health budgets that are already constrained and ...
    • Clonal Hematopoiesis and Risk of Atherosclerotic Cardiovascular Disease 

      Jaiswal, Siddhartha; Natarajan, Pradeep; Silver, Alexander J; Gibson, Christopher J; Bick, Alexander G; Shvartz, Eugenia; McConkey, Marie et al. (Massachusetts Medical Society, 2017-07-13)
      BACKGROUND: Clonal hematopoiesis of indeterminate potential (CHIP), which is defined as the presence of an expanded somatic blood-cell clone in persons without other hematologic abnormalities, is common among older persons ...
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; König, Inke R; Weeke, Peter E et al. (Massachusetts Medical Society, 2016-03-02)
      BACKGROUND The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS Through DNA genotyping, we tested 54,003 ...
    • Coding Variation in ANGPTL4, LPL, and SVEP1 and the Risk of Coronary Disease (vol 374, pg 1134, 2016) 

      Stitziel, Nathan O; Stirrups, Kathleen Elizabeth; Masca, Nicholas GD; Erdmann, Jeanette; Ferrario, Paola G; Koenig, Inke R; Weeke, Peter E et al. (2016-05-12)
      Abstract BACKGROUND The discovery of low-frequency coding variants affecting the risk of coronary artery disease has facilitated the identification of therapeutic targets. METHODS Through DNA genotyping, we tested 54,003 ...
    • Commentary on "A meta-analysis but not a systematic review: an evaluation of the Global BMI Mortality Collaboration". 

      Bhupathiraju, Shilpa N; Di Angelantonio, Emanuele; Danesh, John; Hu, Frank B (2017-08)
    • Distinct genetic architectures for syndromic and nonsyndromic congenital heart defects identified by exome sequencing. 

      Sifrim, Alejandro; Hitz, Marc-Phillip; Wilsdon, Anna; Breckpot, Jeroen; Turki, Saeed H Al; Thienpont, Bernard; McRae, Jeremy et al. (2016-09)
    • Efficiency and safety of varying the frequency of whole blood donation: randomised trial of 45,000 donors 

      Di Angelantonio, E; Thompson, SG; Kaptoge, S; Moore, C; Walker, M; Danesh, John; Ouwehand, W
      Background Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed. We compared ...
    • Exome-wide association study of plasma lipids in >300,000 individuals. 

      Liu, Dajiang J; Peloso, Gina M; Yu, Haojie; Butterworth, Adam Stuart; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish et al. (Springer Nature, 2017-12)
      We report four novel loci associated with blood pressure regulation, and one independent variant at an established blood pressure locus. This analysis highlights several candidate genes with variation that alters protein ...
    • Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms 

      Howson, Joanna McCammond; Zhao, W; Barnes, Daniel Robert; Ho, W-K; Young, R; Paul, Dirk Stefan; Waite, LL et al.
      Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional ...
    • Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference. 

      Corbin, Laura J; Tan, Vanessa Y; Hughes, David A; Wade, Kaitlin H; Paul, Dirk Stefan; Tansey, Katherine E; Butcher, Frances et al. (Springer Nature, 2018-02-19)
      Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks ...
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic invalidation of Lp-PLA$_{2}$ as a therapeutic target: Large-scale study of five functional Lp-PLA$_{2}$-lowering alleles 

      Gregson, JM; Freitag, DF; Surendran, Praveen; Stitziel, NO; Chowdhury, Rajiv; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (SAGE Publications Ltd, 2017-03-01)
      $\textbf{Aims}$ Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A$_{2}$ (Lp-PLA$_{2}$), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether ...
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 

      International Consortium for Blood Pressure Genome-Wide Association Studies,; Ehret, Georg B; Munroe, Patricia B; Rice, Kenneth M; Bochud, Murielle; Johnson, Andrew D; Chasman, Daniel I et al. (2011-09-11)
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P; Hamby, Stephen E; Saleheen, Danish; Hopewell, Jenna C; Zeng, Lingyao; Assimes, Themistocles L; Kanoni, Stavroula et al. (Massachusetts Medical Society, 2015-04-23)
      The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a genetic approach to investigate the association between height ...
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)
    • Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. 

      Strawbridge, Rona J; Dupuis, Josée; Prokopenko, Inga; Barker, Adam; Ahlqvist, Emma; Rybin, Denis; Petrie, John R et al. (2011-10)
    • Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. 

      Saxena, Richa; Saleheen, Danish; Been, Latonya F; Garavito, Martha L; Braun, Timothy; Bjonnes, Andrew; Young, Robin et al. (2013-05)
      We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico ...
    • Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. 

      Jiang, Xia; O'Reilly, Paul F; Aschard, Hugues; Aschard, Hugues; Hsu, Yi-Hsiang; Richards, J Brent; Dupuis, Josée et al. (2018-01-17)
      Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, ...
    • Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. 

      Ji, Sun-Gou; Juran, Brian D; Mucha, Sören; Folseraas, Trine; Jostins, Luke; Melum, Espen; Kumasaka, Natsuhiko et al. (2017-02)