Now showing items 9-16 of 16

    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P.; Hamby, Stephen E.; Saleheen, Danish; Hopewell, Jenna C.; Zeng, Lingyao; Assimes, Themistocles L.; Kanoni, Stavroula et al. (Massachusetts Medical Society, 2015-04-23)
      The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a genetic approach to investigate the association between ...
    • Inflammatory Cytokines and Risk of Coronary Heart Disease: New Prospective Study and Updated Meta-Analysis 

      Kaptoge, Stephen; Seshasai, Sreenivasa Rao Kondapally; Gao, Pei; Freitag, Daniel F.; Butterworth, Adam S.; Borglykke, Anders; Di Angelantonio, Emanuele et al. (Oxford Journals, 2013-09-11)
      Aims Because low-grade inflammation may play a role in the pathogenesis of coronary heart disease (CHD), and pro-inflammatory cytokines govern inflammatory cascades, this study aimed to assess the associations of several ...
    • Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour 

      Silarova, Barbora; Lucas, Joanne; Butterworth, Adam S.; Di Angelantonio, Emanuele; Girling, Christine; Lawrence, Kathryn; Mackintosh, Stuart et al. (BioMed Central, 2015)
      Background: Cardiovascular disease (CVD) remains the leading cause of death globally. Primary prevention of CVD requires cost-effective strategies to identify individuals at high risk in order to help target preventive ...
    • The INTERVAL Trial to determine whether intervals between blood donations can be safely and acceptably decreased to optimise blood supply: study protocol for a randomised controlled trial 

      Moore, Carmel; Sambrook, Jennifer; Walker, Matthew; Tolkien, Zoe; Kaptoge, Stephen; Allen, David; Mehenny, Susan et al. (BioMed Central, 2014-09-17)
      Background Ageing populations may demand more blood transfusions, but the blood supply could be limited by difficulties in attracting and retaining a decreasing pool of younger donors. One approach to increase blood ...
    • Lipoprotein(a) and the risk of vascular disease 

      Erqou, Sebhat (Journal of the American Medical Association, Nature Reviews Cardiology, Archives of Internal Medicine, European Journal of Epidemiology, Journal American College of Cardiology, 2010-05-04)
      Background: Lipoprotein(a) [Lp(a)] is composed of a low density-lipoprotein (LDL) particle and a glycoprotein molecule known as apolipoprotein(a) [apo(a)]. Apo(a) exists in several differently-sized isoforms and is ...
    • PhenoScanner: a database of human genotype-phenotype associations 

      Staley, James R.; Blackshaw, James; Kamat, Mihir A.; Ellis, Steve; Surendran, Praveen; Sun, Benjamin B.; Paul, Dirk S. et al. (Oxford University Press, 2016)
      PhenoScanner is a curated database of publicly available results from large-scale genetic association studies. This tool aims to facilitate “phenome scans”, the cross-referencing of genetic variants with many phenotypes, ...
    • The association between psychiatric diagnosis and violent re-offending in adult offenders in the community 

      Grann, Martin; Danesh, John; Fazel, Seena (2008-11-25)
      Abstract Background High rates of repeat offending are common across nations that are socially and culturally different. Although psychiatric disorders are believed to be risk factors for violent reoffending, the available ...
    • Tobacco use and the risk of cardiovascular diseases in developed and developing countries 

      Alexander, Myriam (2013-10-08)
      The association between cigarette smoking and the risk of cardiovascular diseases (CVD) is well established. However, the effect of other, less common, types of smoking on CVD risk, such as pipes and cigars in developed ...