Now showing items 22-41 of 64

    • Efficiency and safety of varying the frequency of whole blood donation: randomised trial of 45,000 donors 

      Di Angelantonio, E; Thompson, SG; Kaptoge, S; Moore, C; Walker, M; Danesh, John; Ouwehand, W
      Background Limits on the frequency of whole blood donation exist primarily to safeguard donor health. However, there is substantial variation across blood services in the maximum frequency of donations allowed. We compared ...
    • Exome-wide association study of plasma lipids in >300,000 individuals. 

      Liu, Dajiang J; Peloso, Gina M; Yu, Haojie; Butterworth, Adam Stuart; Wang, Xiao; Mahajan, Anubha; Saleheen, Danish et al. (Springer Nature, 2017-12)
      We report four novel loci associated with blood pressure regulation, and one independent variant at an established blood pressure locus. This analysis highlights several candidate genes with variation that alters protein ...
    • Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms 

      Howson, Joanna McCammond; Zhao, W; Barnes, Daniel Robert; Ho, W-K; Young, R; Paul, Dirk Stefan; Waite, LL et al.
      Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional ...
    • Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference. 

      Corbin, Laura J; Tan, Vanessa Y; Hughes, David A; Wade, Kaitlin H; Paul, Dirk Stefan; Tansey, Katherine E; Butcher, Frances et al. (Springer Nature, 2018-02-19)
      Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks ...
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic invalidation of Lp-PLA$_{2}$ as a therapeutic target: Large-scale study of five functional Lp-PLA$_{2}$-lowering alleles 

      Gregson, JM; Freitag, DF; Surendran, Praveen; Stitziel, NO; Chowdhury, Rajiv; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (SAGE Publications Ltd, 2017-03-01)
      $\textbf{Aims}$ Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A$_{2}$ (Lp-PLA$_{2}$), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether ...
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 

      International Consortium for Blood Pressure Genome-Wide Association Studies,; Ehret, Georg B; Munroe, Patricia B; Rice, Kenneth M; Bochud, Murielle; Johnson, Andrew D; Chasman, Daniel I et al. (2011-09-11)
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P; Hamby, Stephen E; Saleheen, Danish; Hopewell, Jenna C; Zeng, Lingyao; Assimes, Themistocles L; Kanoni, Stavroula et al. (Massachusetts Medical Society, 2015-04-23)
      The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a genetic approach to investigate the association between height ...
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)
    • Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. 

      Strawbridge, Rona J; Dupuis, Josée; Prokopenko, Inga; Barker, Adam; Ahlqvist, Emma; Rybin, Denis; Petrie, John R et al. (2011-10)
    • Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India. 

      Saxena, Richa; Saleheen, Danish; Been, Latonya F; Garavito, Martha L; Braun, Timothy; Bjonnes, Andrew; Young, Robin et al. (2013-05)
      We performed a genome-wide association study (GWAS) and a multistage meta-analysis of type 2 diabetes (T2D) in Punjabi Sikhs from India. Our discovery GWAS in 1,616 individuals (842 case subjects) was followed by in silico ...
    • Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. 

      Jiang, Xia; O'Reilly, Paul F; Aschard, Hugues; Aschard, Hugues; Hsu, Yi-Hsiang; Richards, J Brent; Dupuis, Josée et al. (2018-01-17)
      Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, ...
    • Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. 

      Ji, Sun-Gou; Juran, Brian D; Mucha, Sören; Folseraas, Trine; Jostins, Luke; Melum, Espen; Kumasaka, Natsuhiko et al. (2017-02)
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert; Freitag, Daniel F; Li, Li; Chu, Audrey Y; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (American Association for the Advancement of Science, 2016-06-01)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Genomic atlas of the human plasma proteome. 

      Sun, Benjamin; Maranville, Joseph C; Peters, James E; Stacey, David; Staley, James R; Blackshaw, James; Burgess, Stephen et al. (Springer Nature, 2018-06-06)
      51 Although proteins are the primary functional units of biology and the direct targets of most 52 drugs, there is limited knowledge of the genetic factors determining inter-individual variation 53 in protein levels. ...
    • Genomics of lipid metabolism: Identifying novel causal pathways and new therapeutic targets for reducing risk of coronary heart disease 

      Harshfield, Eric; Stacey, D; Paul, Dirk Stefan; Koulman, Albert; Wood, Angela Mary; Butterworth, Adam Stuart; Fauman, EB et al. (John Wiley & Sons Inc., 2016-09-28)
      Coronary heart disease (CHD) is one of the leading causes of death worldwide; mortality rates are expected to continue to rise over the coming decades. Circulating lipids have been shown to be strongly and linearly associated ...
    • Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity 

      Saleheen, D; Natarajan, P; Armean, IM; Zhao, W; Rasheed, A; Khetarpal, SA; Won, H-H et al. (Nature Publishing Group, 2017-04-13)
      A major goal of biomedicine is to understand the function of every gene in the human genome. Loss-of-function mutations can disrupt both copies of a given gene in humans and phenotypic analysis of such 'human knockouts' ...
    • Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease 

      Zhao, W; Rasheed, A; Tikkanen, E; Lee, J-J; Butterworth, Adam Stuart; Howson, Joanna McCammond; Assimes, TL et al.
      To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D ...
    • Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 

      Schormair, Barbara; Zhao, Chen; Bell, Steven; Tilch, Erik; Salminen, Aaro V; Pütz, Benno; Dauvilliers, Yves et al. (Elsevier, 2017-11-01)
      BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve ...
    • Inflammatory Cytokines and Risk of Coronary Heart Disease: New Prospective Study and Updated Meta-Analysis 

      Kaptoge, Stephen Kipkemoi; Seshasai, Sreenivasa Rao Kondapally; Gao, Pei; Freitag, Daniel Franz; Butterworth, Adam Stuart; Borglykke, Anders; Di, Angelantonio Emanuele et al. (Oxford Journals, 2013-09-11)
      Aims Because low-grade inflammation may play a role in the pathogenesis of coronary heart disease (CHD), and pro-inflammatory cytokines govern inflammatory cascades, this study aimed to assess the associations of several ...