Now showing items 20-39 of 48

    • Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms 

      Howson, Joanna McCammond; Zhao, W; Barnes, Daniel Robert; Ho, W-K; Young, R; Paul, Dirk Stefan; Waite, LL et al.
      Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional ...
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic invalidation of Lp-PLA$_{2}$ as a therapeutic target: Large-scale study of five functional Lp-PLA$_{2}$-lowering alleles 

      Gregson, JM; Freitag, DF; Surendran, Praveen; Stitziel, NO; Chowdhury, Rajiv; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (SAGE Publications Ltd, 2017-03-01)
      $\textbf{Aims}$ Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A$_{2}$ (Lp-PLA$_{2}$), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether ...
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P; Hamby, Stephen E; Saleheen, Danish; Hopewell, Jenna C; Zeng, Lingyao; Assimes, Themistocles L; Kanoni, Stavroula et al. (2015-04-23)
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)
    • Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. 

      Ji, Sun-Gou; Juran, Brian D; Mucha, Sören; Folseraas, Trine; Jostins, Luke; Melum, Espen; Kumasaka, Natsuhiko et al. (2017-02)
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert; Freitag, Daniel F; Li, Li; Chu, Audrey Y; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (2016-06-01)
    • Genomics of lipid metabolism: Identifying novel causal pathways and new therapeutic targets for reducing risk of coronary heart disease 

      Harshfield, Eric; Stacey, D; Paul, Dirk Stefan; Koulman, Albert; Wood, Angela Mary; Butterworth, Adam Stuart; Fauman, EB et al. (John Wiley & Sons Inc., 2016-09-28)
      Coronary heart disease (CHD) is one of the leading causes of death worldwide; mortality rates are expected to continue to rise over the coming decades. Circulating lipids have been shown to be strongly and linearly associated ...
    • Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity 

      Saleheen, D; Natarajan, P; Armean, IM; Zhao, W; Rasheed, A; Khetarpal, SA; Won, H-H et al. (Nature Publishing Group, 2017-04-13)
      A major goal of biomedicine is to understand the function of every gene in the human genome. Loss-of-function mutations can disrupt both copies of a given gene in humans and phenotypic analysis of such 'human knockouts' ...
    • Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease 

      Zhao, W; Rasheed, A; Tikkanen, E; Lee, J-J; Butterworth, Adam Stuart; Howson, Joanna McCammond; Assimes, TL et al.
      To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D ...
    • Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 

      Schormair, Barbara; Zhao, Chen; Bell, Steven; Tilch, Erik; Salminen, Aaro V; Pütz, Benno; Dauvilliers, Yves et al. (Elsevier, 2017-11-01)
      BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve ...
    • Inflammatory Cytokines and Risk of Coronary Heart Disease: New Prospective Study and Updated Meta-Analysis 

      Kaptoge, Stephen Kipkemoi; Seshasai, Sreenivasa Rao Kondapally; Gao, Pei; Freitag, Daniel Franz; Butterworth, Adam Stuart; Borglykke, Anders; Di, Angelantonio Emanuele et al. (2013-09-11)
    • Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour 

      Silarova, Barbora; Lucas, Joanne; Butterworth, Adam S; Di Angelantonio, Emanuele; Girling, Christine; Lawrence, Kathryn; Mackintosh, Stuart et al. (2015-09-07)
      Abstract Background Cardiovascular disease (CVD) remains the leading cause of death globally. Primary prevention of CVD requires cost-effective strategies to identify individuals ...
    • Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour 

      Silarova, Barbora; Lucas, Joanne; Butterworth, Adam Stuart; Di, Angelantonio Emanuele; Girling, Christine; Lawrence, Kathryn; Mackintosh, Stuart et al. (2015)
    • Interpretation of the evidence for the efficacy and safety of statin therapy. 

      Collins, Rory; Reith, Christina; Emberson, Jonathan; Armitage, Jane; Baigent, Colin; Blackwell, Lisa; Blumenthal, Roger et al. (2016-11)
    • The INTERVAL Trial to determine whether intervals between blood donations can be safely and acceptably decreased to optimise blood supply: study protocol for a randomised controlled trial 

      Moore, Carmel; Sambrook, Jennifer; Walker, Matthew; Tolkien, Zoe; Kaptoge, Stephen Kipkemoi; Allen, David; Mehenny, Susan et al. (2014-09-17)
    • Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma 

      Farahi, Neda; Paige, E; Balla, J; Prudence, E; Ferreira, RC; Southwood, M; Appleby, SL et al. (Oxford University Press, 2017-02-17)
      The Asp358Ala variant in the interleukin-6 receptor (IL-6R) gene has been implicated in asthma, autoimmune and cardiovascular disorders, but its role in other respiratory conditions such as chronic obstructive pulmonary ...
    • New blood pressure associated loci identified in meta-analyses of 475,000 individuals 

      Howson, Joanna McCammond; Danesh, John; Surendran, Praveen; Butterworth, Adam Stuart (American Heart Association, 2017-10-13)
      Background: Genome-wide association studies have recently identified over 400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier work identified and validated 56 single nucleotide variants ...
    • Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study 

      Peters, SA; van, der Schouw YT; Wood, Angela Mary; Sweeting, Michael John; Moons, KG; Weiderpass, E; Arriola, L et al. (SAGE Publications Ltd, 2016-11)
      OBJECTIVE: There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity ...
    • PhenoScanner: a database of human genotype-phenotype associations 

      Staley, James R; Blackshaw, James; Kamat, Mihir Anant; Ellis, Steve; Surendran, Praveen; Sun, Benjamin; Paul, Dirk Stefan et al. (2016)