Now showing items 22-41 of 59

    • Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms 

      Howson, Joanna McCammond; Zhao, W; Barnes, Daniel Robert; Ho, W-K; Young, R; Paul, Dirk Stefan; Waite, LL et al.
      Coronary artery disease (CAD) is a leading cause of morbidity and mortality worldwide. Although 58 genomic regions have been associated with CAD thus far, most of the heritability is unexplained, indicating that additional ...
    • Formalising recall by genotype as an efficient approach to detailed phenotyping and causal inference. 

      Corbin, Laura J; Tan, Vanessa Y; Hughes, David A; Wade, Kaitlin H; Paul, Dirk Stefan; Tansey, Katherine E; Butcher, Frances et al. (Springer Nature, 2018-02-19)
      Detailed phenotyping is required to deepen our understanding of the biological mechanisms behind genetic associations. In addition, the impact of potentially modifiable risk factors on disease requires analytical frameworks ...
    • The genetic architecture of type 2 diabetes. 

      Fuchsberger, Christian; Flannick, Jason; Teslovich, Tanya M; Mahajan, Anubha; Agarwala, Vineeta; Gaulton, Kyle J; Ma, Clement et al. (2016-08)
      The genetic architecture of common traits, including the number, frequency, and effect sizes of inherited variants that contribute to individual risk, has been long debated. Genome-wide association studies have identified ...
    • Genetic invalidation of Lp-PLA$_{2}$ as a therapeutic target: Large-scale study of five functional Lp-PLA$_{2}$-lowering alleles 

      Gregson, JM; Freitag, DF; Surendran, Praveen; Stitziel, NO; Chowdhury, Rajiv; Burgess, Stephen; Kaptoge, Stephen Kipkemoi et al. (SAGE Publications Ltd, 2017-03-01)
      $\textbf{Aims}$ Darapladib, a potent inhibitor of lipoprotein-associated phospholipase A$_{2}$ (Lp-PLA$_{2}$), has not reduced risk of cardiovascular disease outcomes in recent randomized trials. We aimed to test whether ...
    • Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 

      International Consortium for Blood Pressure Genome-Wide Association Studies,; Ehret, Georg B; Munroe, Patricia B; Rice, Kenneth M; Bochud, Murielle; Johnson, Andrew D; Chasman, Daniel I et al. (2011-09-11)
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P; Hamby, Stephen E; Saleheen, Danish; Hopewell, Jenna C; Zeng, Lingyao; Assimes, Themistocles L; Kanoni, Stavroula et al. (Massachusetts Medical Society, 2015-04-23)
      The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a genetic approach to investigate the association between height ...
    • The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. 

      Ehret, Georg B; Ferreira, Teresa; Chasman, Daniel I; Jackson, Anne U; Schmidt, Ellen M; Johnson, Toby; Thorleifsson, Gudmar et al. (2016-10)
    • Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels. 

      Jiang, Xia; O'Reilly, Paul F; Aschard, Hugues; Aschard, Hugues; Hsu, Yi-Hsiang; Richards, J Brent; Dupuis, Josée et al. (2018-01-17)
      Vitamin D is a steroid hormone precursor that is associated with a range of human traits and diseases. Previous GWAS of serum 25-hydroxyvitamin D concentrations have identified four genome-wide significant loci (GC, ...
    • Genome-wide association study of primary sclerosing cholangitis identifies new risk loci and quantifies the genetic relationship with inflammatory bowel disease. 

      Ji, Sun-Gou; Juran, Brian D; Mucha, Sören; Folseraas, Trine; Jostins, Luke; Melum, Espen; Kumasaka, Natsuhiko et al. (2017-02)
    • A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease 

      Scott, Robert; Freitag, Daniel F; Li, Li; Chu, Audrey Y; Surendran, Praveen; Young, Robin; Grarup, Niels et al. (American Association for the Advancement of Science, 2016-06-01)
      Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...
    • Genomics of lipid metabolism: Identifying novel causal pathways and new therapeutic targets for reducing risk of coronary heart disease 

      Harshfield, Eric; Stacey, D; Paul, Dirk Stefan; Koulman, Albert; Wood, Angela Mary; Butterworth, Adam Stuart; Fauman, EB et al. (John Wiley & Sons Inc., 2016-09-28)
      Coronary heart disease (CHD) is one of the leading causes of death worldwide; mortality rates are expected to continue to rise over the coming decades. Circulating lipids have been shown to be strongly and linearly associated ...
    • Human knockouts and phenotypic analysis in a cohort with a high rate of consanguinity 

      Saleheen, D; Natarajan, P; Armean, IM; Zhao, W; Rasheed, A; Khetarpal, SA; Won, H-H et al. (Nature Publishing Group, 2017-04-13)
      A major goal of biomedicine is to understand the function of every gene in the human genome. Loss-of-function mutations can disrupt both copies of a given gene in humans and phenotypic analysis of such 'human knockouts' ...
    • Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease 

      Zhao, W; Rasheed, A; Tikkanen, E; Lee, J-J; Butterworth, Adam Stuart; Howson, Joanna McCammond; Assimes, TL et al.
      To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D ...
    • Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 

      Schormair, Barbara; Zhao, Chen; Bell, Steven; Tilch, Erik; Salminen, Aaro V; Pütz, Benno; Dauvilliers, Yves et al. (Elsevier, 2017-11-01)
      BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve ...
    • Inflammatory Cytokines and Risk of Coronary Heart Disease: New Prospective Study and Updated Meta-Analysis 

      Kaptoge, Stephen Kipkemoi; Seshasai, Sreenivasa Rao Kondapally; Gao, Pei; Freitag, Daniel Franz; Butterworth, Adam Stuart; Borglykke, Anders; Di, Angelantonio Emanuele et al. (Oxford Journals, 2013-09-11)
      Aims Because low-grade inflammation may play a role in the pathogenesis of coronary heart disease (CHD), and pro-inflammatory cytokines govern inflammatory cascades, this study aimed to assess the associations of several ...
    • Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour 

      Silarova, Barbora; Lucas, Joanne; Butterworth, Adam S; Di Angelantonio, Emanuele; Girling, Christine; Lawrence, Kathryn; Mackintosh, Stuart et al. (2015-09-07)
      Abstract Background Cardiovascular disease (CVD) remains the leading cause of death globally. Primary prevention of CVD requires cost-effective strategies to identify individuals ...
    • Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour 

      Silarova, Barbora; Lucas, Joanne; Butterworth, Adam Stuart; Di, Angelantonio Emanuele; Girling, Christine; Lawrence, Kathryn; Mackintosh, Stuart et al. (BioMed Central, 2015)
      Background: Cardiovascular disease (CVD) remains the leading cause of death globally. Primary prevention of CVD requires cost-effective strategies to identify individuals at high risk in order to help target preventive ...
    • Interpretation of the evidence for the efficacy and safety of statin therapy. 

      Collins, Rory; Reith, Christina; Emberson, Jonathan; Armitage, Jane; Baigent, Colin; Blackwell, Lisa; Blumenthal, Roger et al. (2016-11)
    • The INTERVAL Trial to determine whether intervals between blood donations can be safely and acceptably decreased to optimise blood supply: study protocol for a randomised controlled trial 

      Moore, Carmel; Sambrook, Jennifer; Walker, Matthew; Tolkien, Zoe; Kaptoge, Stephen Kipkemoi; Allen, David; Mehenny, Susan et al. (BioMed Central, 2014-09-17)
      Background Ageing populations may demand more blood transfusions, but the blood supply could be limited by difficulties in attracting and retaining a decreasing pool of younger donors. One approach to increase blood supply ...
    • Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes. 

      Malik, Rainer; Chauhan, Ganesh; Traylor, Matthew Stephen; Sargurupremraj, Muralidharan; Okada, Yukinori; Mishra, Aniket; Rutten-Jacobs, Loes Carola et al. (Springer Nature, 2018-04)
      Stroke has multiple etiologies but the underlying genes and pathways are largely unknown. We conducted a multi-ancestry genome-wide association meta-analysis in 521,612 individuals (67,162 cases and 454,450 controls) and ...