Now showing items 27-46 of 46

    • Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease 

      Zhao, W; Rasheed, A; Tikkanen, E; Lee, J-J; Butterworth, Adam Stuart; Howson, Joanna McCammond; Assimes, TL et al.
      To evaluate the shared genetic etiology of type 2 diabetes (T2D) and coronary heart disease (CHD), we conducted a genome-wide, multi-ancestry study of genetic variation for both diseases in up to 265,678 subjects for T2D ...
    • Identification of novel risk loci for restless legs syndrome in genome-wide association studies in individuals of European ancestry: a meta-analysis. 

      Schormair, Barbara; Zhao, Chen; Bell, Steven; Tilch, Erik; Salminen, Aaro V; Pütz, Benno; Dauvilliers, Yves et al. (Elsevier, 2017-11-01)
      BACKGROUND: Restless legs syndrome is a prevalent chronic neurological disorder with potentially severe mental and physical health consequences. Clearer understanding of the underlying pathophysiology is needed to improve ...
    • Inflammatory Cytokines and Risk of Coronary Heart Disease: New Prospective Study and Updated Meta-Analysis 

      Kaptoge, Stephen Kipkemoi; Seshasai, Sreenivasa Rao Kondapally; Gao, Pei; Freitag, Daniel Franz; Butterworth, Adam Stuart; Borglykke, Anders; Di, Angelantonio Emanuele et al. (2013-09-11)
    • Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour 

      Silarova, Barbora; Lucas, Joanne; Butterworth, Adam S; Di Angelantonio, Emanuele; Girling, Christine; Lawrence, Kathryn; Mackintosh, Stuart et al. (2015-09-07)
      Abstract Background Cardiovascular disease (CVD) remains the leading cause of death globally. Primary prevention of CVD requires cost-effective strategies to identify individuals ...
    • Information and Risk Modification Trial (INFORM): design of a randomised controlled trial of communicating different types of information about coronary heart disease risk, alongside lifestyle advice, to achieve change in health-related behaviour 

      Silarova, Barbora; Lucas, Joanne; Butterworth, Adam Stuart; Di, Angelantonio Emanuele; Girling, Christine; Lawrence, Kathryn; Mackintosh, Stuart et al. (2015)
    • Interpretation of the evidence for the efficacy and safety of statin therapy. 

      Collins, Rory; Reith, Christina; Emberson, Jonathan; Armitage, Jane; Baigent, Colin; Blackwell, Lisa; Blumenthal, Roger et al. (2016-11)
    • The INTERVAL Trial to determine whether intervals between blood donations can be safely and acceptably decreased to optimise blood supply: study protocol for a randomised controlled trial 

      Moore, Carmel; Sambrook, Jennifer; Walker, Matthew; Tolkien, Zoe; Kaptoge, Stephen Kipkemoi; Allen, David; Mehenny, Susan et al. (2014-09-17)
    • Neutrophil-mediated IL-6 receptor trans-signaling and the risk of chronic obstructive pulmonary disease and asthma 

      Farahi, Neda; Paige, E; Balla, J; Prudence, E; Ferreira, RC; Southwood, M; Appleby, SL et al. (Oxford University Press, 2017-02-17)
      The Asp358Ala variant in the interleukin-6 receptor (IL-6R) gene has been implicated in asthma, autoimmune and cardiovascular disorders, but its role in other respiratory conditions such as chronic obstructive pulmonary ...
    • New blood pressure associated loci identified in meta-analyses of 475,000 individuals 

      Howson, Joanna McCammond; Danesh, John; Surendran, Praveen; Butterworth, Adam Stuart (American Heart Association, 2017-10-13)
      Background: Genome-wide association studies have recently identified over 400 loci that harbor DNA sequence variants that influence blood pressure (BP). Our earlier work identified and validated 56 single nucleotide variants ...
    • Parity, breastfeeding and risk of coronary heart disease: A pan-European case-cohort study 

      Peters, SA; van, der Schouw YT; Wood, Angela Mary; Sweeting, Michael John; Moons, KG; Weiderpass, E; Arriola, L et al. (SAGE Publications Ltd, 2016-11)
      OBJECTIVE: There is uncertainty about the direction and magnitude of the associations between parity, breastfeeding and the risk of coronary heart disease (CHD). We examined the separate and combined associations of parity ...
    • PhenoScanner: a database of human genotype-phenotype associations 

      Staley, James R; Blackshaw, James; Kamat, Mihir Anant; Ellis, Steve; Surendran, Praveen; Sun, Benjamin; Paul, Dirk Stefan et al. (2016)
    • Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels 

      Emdin, Connor A; Khera, Amit V; Natarajan, Pradeep; Klarin, Derek; Won, Hong-Hee; Peloso, Gina M; Stitziel, Nathan O et al. (Elsevier, 2016-12-27)
      Background Genomic analyses have suggested that the LPA gene and its associated plasma biomarker, lipoprotein(a) (Lp[a]), represent a causal risk factor for coronary heart disease (CHD). As such, lowering Lp(a) levels has ...
    • Platelet function is modified by common sequence variation in megakaryocyte super enhancers 

      Petersen, R; Lambourne, John Joseph; Javierre, BM; Grassi, Luigi; Kreuzhuber, R; Ruklisa, Dace; Rosa, IM et al. (Springer Nature, 2017-07-13)
      Linking non-coding genetic variants associated with the risk of diseases or disease-relevant traits to target genes is a crucial step to realize GWAS potential in the introduction of precision medicine. Here we set out to ...
    • Rare and low-frequency coding variants alter human adult height 

      Stirrups, Kathleen Elizabeth; Butterworth, Adam Stuart; Chowdhury, Rajiv; Danesh, John; Di, Angelantonio Emanuele; Howson, Joanna McCammond; Surendran, Praveen et al. (Nature Publishing Group, 2017-02-09)
      Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome-wide association studies. Here, we report 83 new height-associated coding variants with lower minor ...
    • Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity 

      Hendricks, AE; Bochukova, EG; Marenne, G; Keogh, Julia Mary; Atanassova, N; Bounds, R; Wheeler, E et al.
      Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants ...
    • Recruitment and representativeness of blood donors in the INTERVAL randomised trial assessing varying inter-donation intervals 

      Moore, Carmel; Bolton, Thomas; Walker, Matthew; Kaptoge, Stephen Kipkemoi; Allen, David; Daynes, Michael; Mehenny, Susan et al. (2016-09-20)
    • Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease 

      Webb, TR; Erdmann, J; Stirrups, Kathleen Elizabeth; Stitziel, NO; Masca, NGD; Jansen, H; Kanoni, S et al. (Elsevier, 2017-02-21)
      BACKGROUND: Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or ...
    • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension 

      Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P; Manning, Alisa K; Grarup, Niels et al. (2016-09-12)
    • Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis 

      Paige, E; Barrett, Jessica Kate; Pennells, Lisa Anne; Sweeting, Michael John; Willeit, P; Di Angelantonio, Emanuele; Gudnason, V et al. (Oxford University Press, 2017-08-04)
      The added value of incorporating information from repeated measurements of blood pressure and cholesterol for cardiovascular disease (CVD) risk prediction has not been rigorously assessed. We used data from the Emerging ...
    • Validation of self-administered nasal swabs and postage for the isolation of $\textit{Staphylococcus aureus}$ 

      Harrison, Ewan Michael; Gleadall, Nicholas; Ba, Xiaoliang; Danesh, John; Peacock, Sharon Jayne; Holmes, Mark Adrian (Microbiology Society, 2016-12-01)
      $\textit{Staphylococcus aureus}$ carriers are at higher risk of $\textit{S. aureus}$ infection and are a reservoir for transmission to others. Detection of nasal $\textit{S. aureus}$ carriage is important for both targeted ...