Now showing items 51-59 of 59

    • Rare and low-frequency coding variants alter human adult height 

      Stirrups, Kathleen Elizabeth; Butterworth, Adam Stuart; Chowdhury, Rajiv; Danesh, John; Di Angelantonio, Emanuele; Howson, Joanna McCammond; Surendran, Praveen et al. (Nature Publishing Group, 2017-02-09)
      Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome-wide association studies. Here, we report 83 new height-associated coding variants with lower minor ...
    • Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity. 

      Hendricks, Audrey E; Bochukova, Elena G; Marenne, Gaëlle; Keogh, Julia Mary; Atanassova, Neli; Bounds, Rebecca; Wheeler, Eleanor et al. (Nature Publishing Group, 2017-06-29)
      Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants ...
    • Recruitment and representativeness of blood donors in the INTERVAL randomised trial assessing varying inter-donation intervals 

      Moore, Carmel; Bolton, Thomas; Walker, Matthew; Kaptoge, Stephen Kipkemoi; Allen, David; Daynes, Michael; Mehenny, Susan et al. (BioMed Central, 2016-09-20)
      Background The interpretation of trial results can be helped by understanding how generalisable they are to the target population for which inferences are intended. INTERVAL, a large pragmatic randomised trial of blood ...
    • Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies 

      Wood, Angela Mary; Kaptoge, Stephen Kipkemoi; Butterworth, Adam Stuart; Paul, Dirk Stefan; Burgess, Stephen; Sweeting, micheal; Bell, Steven et al. (Elsevier, 2018-04-14)
      Background Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease ...
    • Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. 

      Flannick, Jason; Fuchsberger, Christian; Mahajan, Anubha; Teslovich, Tanya M; Agarwala, Vineeta; Gaulton, Kyle J; Caulkins, Lizz et al. (Springer Nature, 2017-12-19)
      dbgfd
    • Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease 

      Webb, TR; Erdmann, J; Stirrups, Kathleen Elizabeth; Stitziel, NO; Masca, NGD; Jansen, H; Kanoni, S et al. (Elsevier, 2017-02-21)
      BACKGROUND: Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or ...
    • Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension 

      Surendran, Praveen; Drenos, Fotios; Young, Robin; Warren, Helen; Cook, James P; Manning, Alisa K; Grarup, Niels et al. (Nature Publishing Group, 2016-09-12)
      High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we ...
    • Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis 

      Paige, E; Barrett, Jessica Kate; Pennells, Lisa Anne; Sweeting, Michael John; Willeit, P; Di Angelantonio, Emanuele; Gudnason, V et al. (Oxford University Press, 2017-08-04)
      The added value of incorporating information from repeated measurements of blood pressure and cholesterol for cardiovascular disease (CVD) risk prediction has not been rigorously assessed. We used data from the Emerging ...
    • Validation of self-administered nasal swabs and postage for the isolation of $\textit{Staphylococcus aureus}$ 

      Harrison, Ewan Michael; Gleadall, Nicholas; Ba, Xiaoliang; Danesh, John; Peacock, Sharon Jayne; Holmes, Mark Adrian (Microbiology Society, 2016-12-01)
      $\textit{Staphylococcus aureus}$ carriers are at higher risk of $\textit{S. aureus}$ infection and are a reservoir for transmission to others. Detection of nasal $\textit{S. aureus}$ carriage is important for both targeted ...