Now showing items 47-55 of 55

• Rare and low-frequency coding variants alter human adult height ﻿

(Nature Publishing Group, 2017-02-09)
Height is a highly heritable, classic polygenic trait with ~700 common associated variants identified so far through genome-wide association studies. Here, we report 83 new height-associated coding variants with lower minor ...
• Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity. ﻿

(Nature Publishing Group, 2017-06-29)
Obesity is a genetically heterogeneous disorder. Using targeted and whole-exome sequencing, we studied 32 human and 87 rodent obesity genes in 2,548 severely obese children and 1,117 controls. We identified 52 variants ...
• Recruitment and representativeness of blood donors in the INTERVAL randomised trial assessing varying inter-donation intervals ﻿

(BioMed Central, 2016-09-20)
Background The interpretation of trial results can be helped by understanding how generalisable they are to the target population for which inferences are intended. INTERVAL, a large pragmatic randomised trial of blood ...
• Risk thresholds for alcohol consumption: combined analysis of individual-participant data on 599,912 current drinkers in 83 prospective studies ﻿

Background Low-risk limits recommended for alcohol consumption vary substantially across different national guidelines. To define thresholds associated with lowest risk for all-cause mortality and cardiovascular disease ...
• Sequence data and association statistics from 12,940 type 2 diabetes cases and controls. ﻿

(Springer Nature, 2017-12-19)
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• Systematic Evaluation of Pleiotropy Identifies 6 Further Loci Associated With Coronary Artery Disease ﻿

(Elsevier, 2017-02-21)
BACKGROUND: Genome-wide association studies have so far identified 56 loci associated with risk of coronary artery disease (CAD). Many CAD loci show pleiotropy; that is, they are also associated with other diseases or ...
• Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension ﻿

(Nature Publishing Group, 2016-09-12)
High blood pressure is a major risk factor for cardiovascular disease and premature death. However, there is limited knowledge on specific causal genes and pathways. To better understand the genetics of blood pressure, we ...
• Use of Repeated Blood Pressure and Cholesterol Measurements to Improve Cardiovascular Disease Risk Prediction: An Individual-Participant-Data Meta-Analysis ﻿

(Oxford University Press, 2017-08-04)
The added value of incorporating information from repeated measurements of blood pressure and cholesterol for cardiovascular disease (CVD) risk prediction has not been rigorously assessed. We used data from the Emerging ...
• Validation of self-administered nasal swabs and postage for the isolation of $\textit{Staphylococcus aureus}$ ﻿

(Microbiology Society, 2016-12-01)
$\textit{Staphylococcus aureus}$ carriers are at higher risk of $\textit{S. aureus}$ infection and are a reservoir for transmission to others. Detection of nasal $\textit{S. aureus}$ carriage is important for both targeted ...