Now showing items 3-6 of 6

    • Fine mapping of type 1 diabetes susceptibility loci and evidence for colocalization of causal variants with lymphoid gene enhancers 

      Onengut-Gumuscu, Suna; Chen, Wei-Min; Burren, Oliver; Cooper, Nick J.; Quinlan, Aaron R.; Mychaleckyj, Josyf C.; Farber, Emily et al. (NPG, 2015-03-09)
      Genetic studies of type 1 diabetes (T1D) have identified 50 susceptibility regions1,2 (www.T1DBase.org) revealing major pathways contributing to risk3, with some loci shared across immune disorders4-6. In order to make ...
    • Genetically Determined Height and Coronary Artery Disease 

      Nelson, Christopher P.; Hamby, Stephen E.; Saleheen, Danish; Hopewell, Jenna C.; Zeng, Lingyao; Assimes, Themistocles L.; Kanoni, Stavroula et al. (Massachusetts Medical Society, 2015-04-23)
      The nature and underlying mechanisms of an inverse association between adult height and the risk of coronary artery disease (CAD) are unclear. Methods We used a genetic approach to investigate the association between ...
    • High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta 

      Daelemans, Caroline; Ritchie, Matthew E.; Smits, Guillaume; Abu-Amero, Sayeda; Sudbery, Ian M.; Forrest, Matthew S.; Campino, Susana et al. (2010-04-19)
      Abstract Background Imprinted genes show expression from one parental allele only and are important for development and behaviour. This extreme mode of allelic imbalance has been described for approximately 56 human genes. ...
    • Low-frequency and rare exome chip variants associate with fasting ​glucose and type 2 diabetes susceptibility 

      Wessel, Jennifer; Chu, Audrey Y.; Willems, Sara M.; Wang, Shuai; Yaghootkar, Hanieh; Brody, Jennifer A.; Dauriz, Marco et al. (Nature Publishing Group, 2015-01-29)
      Fasting ​glucose and ​insulin are intermediate traits for type 2 diabetes. Here we explore the role of coding variation on these traits by analysis of variants on the HumanExome BeadChip in 60,564 non-diabetic individuals ...