Now showing items 1-5 of 5

    • Breaking the waves: improved detection of copy number variation from microarray-based comparative genomic hybridization 

      Marioni, John Carlo; Thorne, Natalie P; Valsesia, Armand; Fitzgerald, Tomas; Redon, Richard; Fiegler, Heike; Andrews, T Daniel et al. (2007-10-25)
      Abstract Background Large-scale high throughput studies using microarray technology have established that copy number variation (CNV) throughout the genome is more frequent than previously thought. Such variation is known ...
    • Data analysis issues for allele-specific expression using Illumina's GoldenGate assay 

      Ritchie, Matthew E; Forrest, Matthew S; Dimas, Antigone S; Daelemans, Caroline; Dermitzakis, Emmanouil T; Deloukas, Panagiotis; Tavare, Simon (2010-05-26)
      Abstract Background High-throughput measurement of allele-specific expression (ASE) is a relatively new and exciting application area for array-based technologies. In this paper, we explore several data sets which make use ...
    • Extent, causes, and consequences of small RNA expression variation in human adipose tissue. 

      Parts, Leopold; Hedman, Åsa K; Keildson, Sarah; Knights, Andrew J; Abreu-Goodger, Cei; van de Bunt, Martijn; Guerra-Assunção, José Afonso et al. (2012-01)
    • Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes. 

      Strawbridge, Rona J; Dupuis, Josée; Prokopenko, Inga; Barker, Adam; Ahlqvist, Emma; Rybin, Denis; Petrie, John R et al. (2011-10)
    • High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta 

      Daelemans, Caroline; Ritchie, Matthew E; Smits, Guillaume; Abu-Amero, Sayeda; Sudbery, Ian M; Forrest, Matthew S; Campino, Susana et al. (2010-04-19)
      Abstract Background Imprinted genes show expression from one parental allele only and are important for development and behaviour. This extreme mode of allelic imbalance has been described for approximately 56 human genes. ...