Browsing by Author "Du, Ming-Qing"
Now showing items 3-12 of 12
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Diffuse large B-cell lymphoma: sub-classification by massive parallel quantitative RT-PCR
Xue, Xuemin; Zeng, Naiyan; Gao, Zifen; Du, Ming-Qing (Nature Publishing Group, 2014-11-24)Diffuse large B-cell lymphoma (DLBCL) is a heterogeneous entity with remarkably variable clinical outcome. Gene expression profiling (GEP) classifies DLBCL into activated B-cell like (ABC), germinal centre B-cell like (GCB) ... -
Early loss of Crebbp confers malignant stem cell properties on lymphoid progenitors.
Horton, Sarah Jayne; Giotopoulos, George; Yun, Haiyang; Vohra, Shabana; Sheppard, Olivia; Bashford-Rogers, Rachael Jennifer; Rashid, MamunurClipson, AlexandraChan, Wai-InSasca, DanielYiangou, LoukiaOsaki, HikariBasheer, FaisalGallipoli, PaoloBurrows, NatalieErdem, AyşegülSybirna, AnastasiyaFoerster, SarahZhao, WanfengSustic, TonciPetrunkina Harrison, AnnaLaurenti, ElisaOkosun, JessicaHodson, Daniel JamesWright, PennySmith, Kenneth GeorgeMaxwell, PatrickFitzgibbon, JudeDu, Ming-QingAdams, David JHuntly, Brian James et al. (2017-09) -
Identification of novel prognostic markers in cervical intraepithelial neoplasia using LDMAS (LOH Data Management and Analysis Software)
Hamoudi, Rifat Akram; El-Hamidi, Amina; Du, Ming-Qing (2005-01-26)Abstract Background Detection of Loss of Heterozygosity (LOH) is one of the most common molecular applications in the study of human diseases, in particular cancer. The technique is commonly used to examine whether a known ... -
KLF2 mutation is the most frequent somatic change in splenic marginal zone lymphoma and identifies a subset with distinct genotype
Clipson, Alexandra; Wang, Ming; de, Leval Laurence; Ashton-Key, Margaret; Wotherspoon, Andrew; Vassiliou, George; Bolli, NiccoloGrove, CarolynMoody, Sarah ElizabethIbarz, Leire EscuderoGundem, GunesBrugger, KimXue, XueminMi, EllaBench, AnthonyScott, MikeLiu, HongxiangFollows, GeorgeRobles, Eloy FCliment, Jose Angel MartinezOscier, DavidWatkins, A JamesDu, Ming-Qing et al. (Nature Publishing Group, 2014-11-27)To characterise the genetics of splenic marginal zone lymphoma (SMZL), we performed whole exome sequencing of 16 cases and identified novel recurrent inactivating mutations in KLF2, a gene whose deficiency was previously ... -
MALT lymphoma: A paradigm of NF-κB dysregulation
Du, Ming-Qing (Elsevier, 2016-08)Extranodal marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT lymphoma) invariably arises from a background of chronic microbial infection and/or autoimmune disorder at diverse mucosal sites. The prolonged ... -
The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) Trial protocol and baseline cohort characteristics: an open-label pre-test : post-test study with blinded outcome assessments
Connick, Peter Vincent; Kolappan, Madhan; Patani, Rickie; Scott, Michael A; Crawley, Charles; He, Xiao-ling; Richardson, KarenBarber, KellyWebber, Daniel JWheeler-Kingshott, Claudia AMTozer, Daniel JohnSamson, Rebecca SThomas, David LDu, Ming-QingLuan, Shi LMichell, Andrew WAltmann, Daniel RThompson, Alan JMiller, David HCompston, David AlastairChandran, Siddharthan et al. (2011-03-02)Abstract Background No treatments are currently available that slow, stop, or reverse disease progression in established multiple sclerosis (MS). The Mesenchymal Stem Cells in Multiple Sclerosis (MSCIMS) trial tests the ... -
The Prognosis of MYC Translocation Positive Diffuse Large B-Cell Lymphoma Depends on The Second Hit
Clipson, Alexandra; Barrans, Sharon; Zeng, Naiyan; Crouch, Simon; Grigoropoulos, Nicholas F; Liu, Hongxiang; Kocialkowski, SylviaWang, MingHuang, YuanxueWorrillow, LisaGoodlad, JohnBuxton, JennyNeat, MichaelFields, PaulWilkins, BridgetGrant, John WWright, PennyEI-Daly, HeshamFollows, George ARoman, EveWatkins, A JamesJohnson, Peter WMJack, AndrewDu, Ming-Qing et al. (Wiley, 2015-01-08)A proportion of MYC translocation positive diffuse large B-cell lymphomas (DLBCL) harbour a BCL2 and/or BCL6 translocation, known as double-hit DLBCL, and are clinically aggressive. It is unknown whether there are other ... -
Significant association between TNFAIP3 inactivation and biased immunoglobulin heavy chain variable region 4-34 usage in mucosa-associated lymphoid tissue lymphoma.
Moody, Sarah Elizabeth; Escudero-Ibarz, Leire; Wang, Ming; Clipson, Alexandra; Ochoa Ruiz, Eguzkine; Dunn-Walters, Deborah; Xue, XueminZeng, NaiyanRobson, AlistairChuang, Shih-SungCogliatti, SergioLiu, HongxiangGoodlad, JohnAshton-Key, MargaretRaderer, MarkusBi, YingwenDu, Ming-Qing et al. (2017-09) -
Significant functional difference between $\small \textit{TNFAIP3}$ truncation and missense mutants
Escudero-Ibarz, L; Wang, Ming; Du, Ming-Qing (Ferrata Storti Foundation, 2016-09) -
Somatic mutation screening using archival formalin-fixed paraffin-embedded tissues by Fluidigm multiplex PCR and Illumina sequencing
Wang, Ming; Escudero-Ibarz, Leire; Moody, Sarah Elizabeth; Zeng, Naiyan; Clipson, Alexandra; Huang, Yuanxue; Xue, XueminGrigoropoulos, Nicholas FBarrans, SharonWorrillow, LisaForshew, TimSu, JingFirth, Andrew EdwinMartin, HowardJack, AndrewBrugger, KimDu, Ming-Qing et al. (Elsevier, 2015-07-09)High throughput somatic mutation screening using formalin-fixed paraffin-embedded (FFPE) tissues is a major challenge due to a lack of established methodology and validated variant calling algorithms. We aimed to develop ...