Now showing items 1-4 of 4

    • A genome annotation-driven approach to cloning the human ORFeome 

      Collins, John E.; Wright, Charmain L.; Edwards, Carol A.; Davis, Mathew P.; Grinham, James A.; Cole, Charlotte G.; Goward, Melanie E. et al. (2004-09-30)
      Abstract We have developed a systematic approach to generating cDNA clones containing full-length open reading frames (ORFs), exploiting knowledge of gene structure from genomic sequence. Each ORF was amplified by PCR from ...
    • High-throughput analysis of candidate imprinted genes and allele-specific gene expression in the human term placenta 

      Daelemans, Caroline; Ritchie, Matthew E.; Smits, Guillaume; Abu-Amero, Sayeda; Sudbery, Ian M.; Forrest, Matthew S.; Campino, Susana et al. (2010-04-19)
      Abstract Background Imprinted genes show expression from one parental allele only and are important for development and behaviour. This extreme mode of allelic imbalance has been described for approximately 56 human genes. ...
    • Sequencing and association analysis of the type 1 diabetes - linked region on chromosome 10p12-q11. 

      Nejentsev, Sergey; Smink, Luc J.; Smyth, Deborah J.; Bailey, Rebecca; Lowe, Christopher E.; Payne, Felicity; Masters, Jennifer et al. (2007-05-17)
      Abstract Background In an effort to locate susceptibility genes for type 1 diabetes (T1D) several genome-wide linkage scans have been undertaken. A chromosomal region designated IDDM10 retained genome-wide significance in ...
    • The evolution of imprinting: chromosomal mapping of orthologues of mammalian imprinted domains in monotreme and marsupial mammals 

      Edwards, Carol A.; Rens, Willem; Clark, Oliver; Mungall, Andrew J.; Hore, Timothy; Marshall Graves, Jennifer A.; Dunham, Ian et al. (2007-09-06)
      Abstract Background The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the ...