Now showing items 2-5 of 5

    • Genomic islands of speciation separate cichlid ecomorphs in an East African crater lake 

      Malinsky, Milan; Challis, Richard J.; Tyers, Alexandra M.; Schiffels, Stephan; Terau, Yohey; Ngatunga, Benjamin P.; Miska, Eric A. et al. (2015-06-18)
      The genomic causes and effects of divergent ecological selection during speciation are still poorly understood. Here, we report the discovery and detailed characterization of early-stage adaptive divergence of two cichlid ...
    • Health and population effects of rare gene knockouts in adult humans with related parents 

      Narasimhan, Vagheesh M.; Hunt, Karen A.; Mason, Dan; Baker, Christopher L.; Karczewski, Konrad J.; Barnes, Michael R.; Barnett, Anthony H. et al. (American Association for the Advancement of Science, 2016-03-03)
      Examining complete gene knockouts within a viable organism can inform on gene function. We sequenced the exomes of 3222 British Pakistani-heritage adults with high parental relatedness, discovering 1111 rare-variant ...
    • No evidence for maintenance of a sympatric Heliconius species barrier by chromosomal inversions 

      Davey, John W; Barker, Sarah L; Rastas, Pasi M; Pinharanda, Ana; Martin, Simon H; Durbin, Richard; McMillan, W Owen et al.
      Mechanisms that suppress recombination are known to help maintain species barriers by preventing the breakup of coadapted gene combinations. The sympatric butterfly species Heliconius melpomene and Heliconius cydno are ...
    • The Sequence Ontology: a tool for the unification of genome annotations 

      Eilbeck, Karen; Lewis, Suzanna E.; Mungall, Christopher J.; Yandell, Mark D.; Stein, Lincoln; Durbin, Richard; Ashburner, Michael (2005-04-29)
      Abstract The Sequence Ontology (SO) is a structured controlled vocabulary for the parts of a genomic annotation. SO provides a common set of terms and definitions that will facilitate the exchange, analysis and management ...