Now showing items 3-15 of 15

• #### Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array ﻿

(Nature Publishing Group, 2016-03-10)
Background: Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, ...
• #### Genetic determinants of telomere length and risk of common cancers: a Mendelian randomization study ﻿

(Oxford University Press, 2015-07-02)
Epidemiological studies have reported inconsistent associations between telomere length (TL) and risk for various cancers. These inconsistencies are likely attributable, in part, to biases that arise due to post-diagnostic ...
• #### A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population ﻿

(Impact Journals, 2016-02-08)
Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated ...
• #### A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease ﻿

(American Association for the Advancement of Science, 2016-06-01)
Regulatory authorities have indicated that new drugs to treat type 2 diabetes (T2D) should not be associated with an unacceptable increase in cardiovascular risk. Human genetics may be able to guide development of antidiabetic ...

(2017-08)
• #### The OncoArray Consortium: a Network for Understanding the Genetic Architecture of Common Cancers ﻿

(American Association for Cancer Research, 2016-10-03)
Background: Common cancers develop through a multistep process often including inherited susceptibility. Collaboration among multiple institutions, and funding from multiple sources, has allowed the development of an ...
• #### Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. ﻿

Objectives: Prostate-specific-antigen (PSA) screening resulted in reduced prostate cancer (PCa) mortality in a large clinical trial, but due to many false positives and overdiagnosis of indolent disease, many guidelines ...
• #### Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium. ﻿

(2016-08-04)
• #### Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status. ﻿

(Oxford University Press, 2016-12)
Molecular and epidemiological differences have been described between $\small \textit{TMPRSS2:ERG}$ fusion-positive and fusion-negative prostate cancer (PrCa). Assuming two molecularly distinct subtypes, we have examined ...

• #### Risk Analysis of Prostate Cancer in PRACTICAL, a Multinational Consortium, Using 25 Known Prostate Cancer Susceptibility Loci ﻿

(AACR, 2015-04-02)
BACKGROUND: Genome-wide association studies have identified multiple genetic variants associated with prostate cancer (PrCa) risk which explain a substantial proportion of familial relative risk. These variants can be used ...
• #### Screening for ovarian cancer in women with varying levels of risk, using annual tests, results in high recall for repeat screening tests. ﻿

(2011-11-23)
Abstract Background We assessed ovarian cancer screening outcomes in women with a positive family history of ovarian cancer divided into a low-, moderate- or high-risk group for development of ovarian cancer. Methods 545 ...
• #### Use of a novel non-parametric version of DEPTH to identify genomic regions associated with prostate cancer risk ﻿

(American Association for Cancer Research, 2016-08-18)
$\textbf{Background:}$ We have developed a GWAS analysis method called DEPTH (DEPendency of association on the number of Top Hits) to identify genomic regions potentially associated with disease by considering overlapping ...